Thomas Frazier

ORCID: 0000-0002-6951-2667
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About
Contact & Profiles
Research Areas
  • Autism Spectrum Disorder Research
  • Bipolar Disorder and Treatment
  • Child and Adolescent Psychosocial and Emotional Development
  • Genetics and Neurodevelopmental Disorders
  • Attention Deficit Hyperactivity Disorder
  • Family and Disability Support Research
  • Adolescent and Pediatric Healthcare
  • Child Nutrition and Feeding Issues
  • Behavioral and Psychological Studies
  • PI3K/AKT/mTOR signaling in cancer
  • Child Development and Digital Technology
  • Virology and Viral Diseases
  • Epilepsy research and treatment
  • Functional Brain Connectivity Studies
  • Fetal and Pediatric Neurological Disorders
  • Schizophrenia research and treatment
  • Pharmacological Effects and Toxicity Studies
  • Genomics and Rare Diseases
  • Stuttering Research and Treatment
  • Neurological disorders and treatments
  • Psychosomatic Disorders and Their Treatments
  • Metabolism and Genetic Disorders
  • Educational and Psychological Assessments
  • Traumatic Brain Injury Research
  • Obsessive-Compulsive Spectrum Disorders

John Carroll University
2006-2025

Autism Speaks
2017-2025

SUNY Upstate Medical University
2023-2025

Cleveland Clinic
2012-2024

Center for Autism and Related Disorders
2012-2024

Cleveland Clinic Lerner College of Medicine
2013-2023

Bryn Mawr College
2018

University of Minnesota
2016-2018

The Ohio State University Wexner Medical Center
2017-2018

Creative Commons
2017

This article presents results from two interrelated studies. The first study conducted a meta-analysis of the published literature since 1990 to determine magnitude achievement problems associated with attention-deficit/hyperactivity disorder (ADHD). Effect sizes were significantly different between participants and without ADHD (sample weighted r = .32, sample d . 71; p .001). Effects also examined according moderators age, gender, domain (reading, math, spelling), measurement method...

10.1177/00222194070400010401 article EN Journal of Learning Disabilities 2007-01-01

Objective: Although the symptoms of autism exhibit quantitative distributions in nature, estimates recurrence risk families have never previously considered or incorporated characterization autistic phenotype among siblings. Method: The authors report results 2,920 children from 1,235 participating a national volunteer register, with at least one child clinically affected by an spectrum disorder and full biological sibling. Results: A traditionally defined additional occurred 10.9% families....

10.1176/appi.ajp.2010.09101470 article EN American Journal of Psychiatry 2010-10-02

Objective To estimate the effectiveness of adherence-promoting psychological interventions for pediatric populations with chronic health conditions.Methods A meta-analysis was conducted on 70 adherencepromoting intervention studies among chronically ill youth using a weighted least squares approach and random effect model.Results Medium effects sizes were found behavioral (mean d ¼.54, 95% confidence interval [CI] ¼ 0.34-0.73,n 10) multi-component ¼.51, CI 0.45-0.57,n 46), while educational...

10.1093/jpepsy/jsm128 article EN Journal of Pediatric Psychology 2008-01-11

Understanding the factor structure of autistic symptomatology is critical to discovery and interpretation causal mechanisms in autism spectrum disorder. We applied confirmatory analysis assessment measurement invariance a large ( N = 9635) accumulated collection reports on quantitative traits using Social Responsiveness Scale, representing broad diversity age, severity, reporter type. A two-factor (corresponding social communication impairment restricted, repetitive behavior) as elaborated...

10.1177/1362361313500382 article EN cc-by-nc Autism 2013-09-09

Background With rates of autism diagnosis continuing to rise, there is an urgent need for effective and efficient service delivery models. Pivotal Response Treatment ( PRT ) considered established treatment spectrum disorder ASD ); however, have been few well‐controlled studies with adequate sample size. The aim this study was conduct a randomized controlled trial evaluate parent training group PRTG targeting language deficits in young children . Methods Fifty‐three significant delay between...

10.1111/jcpp.12354 article EN Journal of Child Psychology and Psychiatry 2014-10-27
Brett Trost Bhooma Thiruvahindrapuram Ada J. S. Chan Worrawat Engchuan Edward J. Higginbotham and 95 more Jennifer Howe Lívia O. Loureiro Miriam S. Reuter Delnaz Roshandel J. Andrew Whitney Mehdi Zarrei Matthew Bookman Cherith Somerville Rulan Shaath Mona Abdi Elbay Aliyev Rohan Patel Thomas Nalpathamkalam Giovanna Pellecchia Omar Hamdan Gaganjot Kaur Zhuozhi Wang Jeffrey R. MacDonald John Wei Wilson W. L. Sung Sylvia Lamoureux Ny Hoang Thanuja Selvanayagam Nicole Deflaux Melissa Geng Siavash Ghaffari John Bates Edwin J. Young Qiliang Ding Carole Shum Lia D’Abate Clarrisa A. Bradley Annabel Rutherford Vernie Aguda Beverly Apresto Nan Chen Sachin Desai Xiaoyan Du Matthew L.Y. Fong Sanjeev Pullenayegum Kozue Samler Ting Wang Karen Ho Tara Paton Sérgio L. Pereira Jo-Anne Herbrick Richard F. Wintle Jonathan Fuerth Juti Noppornpitak Heather Ward Patrick Magee Ayman Al Baz Usanthan Kajendirarajah Sharvari Kapadia Jim Vlasblom Monica Valluri Joseph Green Vicki Seifer Morgan Quirbach Olivia Rennie Elizabeth Kelley Nina Masjedi Catherine Lord Michael J. Szego Ma’n H. Zawati Michael Lang Lisa J. Strug Christian R. Marshall Gregory Costain Kristina Calli Alana Iaboni Afiqah Yusuf Patricia Ambrozewicz Louise Gallagher David G. Amaral Jessica Brian Mayada Elsabbagh Stelios Georgiades Daniel S. Messinger Sally Ozonoff Jonathan Sebat Calvin Sjaarda Isabel M. Smith Peter Szatmari Lonnie Zwaigenbaum Azadeh Kushki Thomas Frazier Jacob Vorstman Khalid A. Fakhro Bridget A. Fernandez M. E. Suzanne Lewis Rosanna Weksberg Marc Fiume Ryan K. C. Yuen Evdokia Anagnostou

10.1016/j.cell.2022.10.009 article EN publisher-specific-oa Cell 2022-11-01

Abstract The relationship between respiratory sinus arrhythmia (RSA) and valence arousal remains unclear. In the present study, associations emotion responses tonic or task‐related changes in RSA were assessed. Specifically, sensitivities of interbeat interval, RSA, skin conductance to values emotional stimuli examined. This study also explored association subjective, expressive, physiological responses. Response measures collected from 56 adults during baseline film‐viewing periods. Tonic...

10.1046/j.1469-8986.2003.00131.x article EN Psychophysiology 2003-11-07

Article Abstract Objective: To examine the proposed disruptive mood dysregulation disorder (DMDD) diagnosis in a child psychiatric outpatient population. Evaluation of DMDD included 4 domains: clinical phenomenology, delimitation from other diagnoses, longitudinal stability, and association with parental disorders. Method: Data were obtained 706 children aged 6-12 years who participated Longitudinal Assessment Manic Symptoms (LAMS) study (sample was accrued November 2005 to 2008). DSM-IV...

10.4088/jcp.12m07674 article EN The Journal of Clinical Psychiatry 2012-10-15

Evidence-based assessment (EBA) streamlines literature reviewing and organizing clinical by targeting the vital few topics, “satisficing,” focusing on three major phases of activity: prediction diagnoses or other criteria, prescription treatment moderating factors, process measurement. EBA is an framework for applying a dozen steps to guide treatment. Technology changing increasing efficiency accuracy scoring feedback, as well innovations that make more intensive feasible. Fully implementing...

10.1111/cpsp.12207 article EN Clinical Psychology Science and Practice 2017-08-28

Background: Many youths with an autism spectrum disorder (ASD) benefit from psychotropic medication treatment of co-morbid symptom patterns consistent attention-deficit/hyperactivity (ADHD). The lack clear indications and algorithms to direct clinical practice has led a very poor understanding overall use for these youths. present study examined the prevalence compared across individuals ASD without caregiver-reported ADHD diagnosis (ASD-only), (ADHD-only), (ASD+ADHD). Correlates were also...

10.1089/cap.2011.0057 article EN Journal of Child and Adolescent Psychopharmacology 2011-12-01

<h3>Importance</h3> Recent reports have demonstrated a higher incidence of autism spectrum disorder (ASD) and substantially elevated autistic trait burden in individuals with neurofibromatosis type 1 (NF1). However, important discrepancies regarding the distribution traits, sex predominance, association between ASD symptoms attentional problems emerged, critical features phenotype within NF1 never been adequately explored. Establishing as monogenic cause for has implications affected...

10.1001/jamapsychiatry.2016.2600 article EN JAMA Psychiatry 2016-10-19

It is recognised that 5% - 10 % of children with macrocephaly and autism spectrum disorder (ASD) and/or intellectual disability (ID) have a heterozygous pathogenic mutation in the PTEN tumour suppressor gene associated hamartoma syndrome. However, clinical features course are unclear not been well documented.We undertook retrospective chart review (< 18 years) mutations to ascertain findings, possible outcomes.Clinical molecular data were collected analysed for 47 patients from 38 eligible...

10.1136/jmedgenet-2016-104484 article EN Journal of Medical Genetics 2017-05-19
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