A5005627762- Neurofibromatosis and Schwannoma Cases
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Meningioma and schwannoma management
- COVID-19 and Mental Health
- Vascular Malformations Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Chromatin Remodeling and Cancer
- Suicide and Self-Harm Studies
- Child and Adolescent Health
- Child and Adolescent Psychosocial and Emotional Development
- Child Development and Digital Technology
- Cellular transport and secretion
- Transcranial Magnetic Stimulation Studies
- Reading and Literacy Development
- Protein Tyrosine Phosphatases
- Functional Brain Connectivity Studies
- Congenital heart defects research
- Adolescent and Pediatric Healthcare
- Peptidase Inhibition and Analysis
- Child Nutrition and Feeding Issues
- Neuroendocrine Tumor Research Advances
- Health Policy Implementation Science
- Obsessive-Compulsive Spectrum Disorders
- Signaling Pathways in Disease
Manchester University NHS Foundation Trust
2016-2025
University of Manchester
2016-2025
Royal Manchester Children's Hospital
2016-2025
Manchester Academic Health Science Centre
2016-2024
Birla Institute of Technology, Mesra
2022-2024
Manchester University
2023
National Health Service
2022
University Foundation
2021
Greater Manchester Mental Health NHS Foundation Trust
2018-2020
Christ University
2020
BackgroundWe describe post-COVID symptomatology in a non-hospitalised, national sample of adolescents aged 11–17 years with PCR-confirmed SARS-CoV-2 infection compared matched negative PCR status.MethodsIn this cohort study, from the Public Health England database who tested positive for between January and March, 2021, were by month test, age, sex, geographical region to negative. 3 months after testing, subsample contacted complete detailed questionnaire, which collected data on...
There has been growing concern in the UK over recent years that a perceived mental health crisis is affecting children and adolescents, although published epidemiological evidence limited.
Self-harm and eating disorders share multiple risk factors, with onset typically during adolescence or early adulthood. We aimed to examine the incidence rates of these psychopathologies among young people in UK 2 years following COVID-19 pandemic.We conducted a population-based study using primary care electronic health records patients aged 10-24 Clinical Practice Research Datalink (CPRD). The observation period was from Jan 1, 2010, March 31, 2022. calculated monthly self-harm according...
Aim To investigate psychopathology in children with neurofibromatosis type 1 (NF1), particularly the prevalence of autism spectrum disorder (ASD) and attention‐deficit–hyperactivity (ADHD) symptomatology, using a population‐based sampling approach. Method Standard questionnaire screen reports were analysed for ASD (Social Responsiveness Scale, SRS), ADHD (Conners’ Parent Rating Scale‐ Revised, CPRS‐R), other psychiatric morbidity (Strengths Difficulties Questionnaire, SDQ) from parents...
To determine the prevalence of autism spectrum disorder (ASD) in Neurofibromatosis Type 1 (NF1).Second-phase population-based epidemiologic study using an allcase NF1 registry a defined UK 4.1 million population area. A total 109 (52.7%) 207 responders from initial screening phase were grouped by parent-rated Social Responsiveness Scale (SRS) as significant ASD (SRS≥76; n = 32), moderate (SRS ≥ 60<76; 29), or non-ASD <60, 48). Twenty-three cases group, 16 ASD, and 8 (total 47), invited...
<h3>Importance</h3> Recent reports have demonstrated a higher incidence of autism spectrum disorder (ASD) and substantially elevated autistic trait burden in individuals with neurofibromatosis type 1 (NF1). However, important discrepancies regarding the distribution traits, sex predominance, association between ASD symptoms attentional problems emerged, critical features phenotype within NF1 never been adequately explored. Establishing as monogenic cause for has implications affected...
Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects first time younger children NF1 co-morbid autism multiparametric imaging outcomes. A single-site triple-blind RCT of simvastatin vs. placebo was done. Assessment (baseline 12-week...
To describe the prevalence of long COVID in children infected for first time (n = 332) or reinfected 243) with Omicron compared test-negative 311). Overall, 12%-16% those met research definition at 3 and 6 months after infection, no evidence difference between cases positive (Pχ2 0.17).
Abstract Our previous study in children and young people (CYP) at 3- 6-months post-infection showed that 12–16% of those infected with the Omicron (B.1.1.529) variant SARS-CoV-2 met research definition Long Covid, no differences between first-positive reinfected CYP. The primary objective current is to explore impact infection on 12 months post infection. 345 CYP aged 11–17 years a first laboratory-confirmed 360 completed an online questionnaire assessing demographics, symptoms, their...
Aim To investigate the cognitive and behavioural phenotype in rare disorders of Ras/ MAPK pathway, namely Noonan, cardiofaciocutaneous ( CFC ), Costello syndromes, particularly prevalence autism spectrum disorder ASD ) attention‐deficit–hyperactivity ADHD ). Method Fifty children were recruited over 10 months through regional genetics service advertisements. A range parent, child, observational measures administered including Autism Diagnostic Interview‐Revised Observation Scale. Results...
Prospective studies of infants at familial risk for autism spectrum disorder (ASD) have yielded insights into the earliest signs but represent heterogeneous samples unclear aetiology. Complementing this approach by studying cohorts with monogenic syndromes associated high rates ASD offers opportunity to elucidate factors that lead ASD. We present first report from a prospective study ten 10-month-old neurofibromatosis type 1 (NF1), prevalence or symptomatology. compared data NF1 large cohort...
This study aimed to investigate the core cognitive deficits in children with neurofibromatosis type 1 (NF1).The recruited 49 NF1 (25 males, 24 females; mean age 11y 9mo [SD 3y 2mo]), 19 healthy siblings of (sibling comparisons; 12y 7mo 2y 7mo], 9 10 females) and 29 from community (community 12 17 females). Participants completed a battery tests including intelligence, academic achievement, attention, visuoperceptual functioning, visual learning, executive non-verbal working memory tests.Our...
Abstract Background Autism is proposed to be characterised by an atypical balance of cortical excitation and inhibition (E/I). However, most studies have examined E/I alterations in older autistic individuals, meaning that findings could part reflect homeostatic compensation. To assess the directionality effects, it necessary examine early lifespan before symptom emergence. Recent explanatory frameworks argued also consider how risk features interact with later developing modifier factors...
Learning difficulties are frequently reported in children with neurofibromatosis type 1 (NF1), yet little is known about the extent and predictors of their academic functions across ages. We aimed to examine developmental patterns achievement these from childhood adolescence how differ demographic NF1-related disease factors. This cross-sectional study integrated data 1512 NF1 (mean age, 11.2 years, SD, 3.62, range, 3-18, 46.5% female patients) 8 institutions. Academic functioning was...
Background: Neurofibromatosis-1 (NF1) is an autosomal dominant neurodevelopmental condition commonly characterised by learning difficulties, with co-occurring autism spectrum conditions in 30% and attention deficit hyperactivity disorder about 50% of affected school-age children. The structural brain phenotype characteristically shows T2-white matter hyperintensities, particularly the thalamus basal ganglia, previous diffusion MRI studies have demonstrated widespread white microstructural...
The prevalence of antidepressant prescribing in children and adolescents increased steadily the United States parts Europe between 2005 2012 despite regulatory safety warnings. Little is known about characteristics those being prescribed antidepressants for first time.A longitudinal study 3-17 year olds was carried out using data from UK Clinical Practice Research Datalink (CPRD) 2000 2015. Changes incidence ever prescriptions them examined.Incidence nearly doubled 2006 2015 rising 1.60...
Aim This study describes the prevalence and severity of perceived fatigue in a young neurofibromatosis type 1 (NF1) population. Methods Ethical approval was obtained NF1 affected Individuals aged 2–18 years from Manchester's clinic invited along with any unaffected siblings. The PedsQL Multidimensional Fatigue Scale Parental child report used. validated measure explores cognitive, physical sleep/rest domains on 0–100 scale. Higher scores indicate less fatigue. children were compared to...