A5059411335- Schizophrenia research and treatment
- Mental Health Research Topics
- Digital Mental Health Interventions
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Mental Health and Patient Involvement
- COVID-19 and Mental Health
- Virtual Reality Applications and Impacts
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Policy Implementation Science
- Art Therapy and Mental Health
- Family Caregiving in Mental Illness
- Telemedicine and Telehealth Implementation
- Ethics in Clinical Research
- Eating Disorders and Behaviors
- Psychotherapy Techniques and Applications
- Sleep and related disorders
- Long-Term Effects of COVID-19
- Treatment of Major Depression
- Empathy and Medical Education
- Psychological and Temporal Perspectives Research
- Pharmacovigilance and Adverse Drug Reactions
- Health, psychology, and well-being
- Optimism, Hope, and Well-being
McPin Foundation
2017-2024
University of Oxford
2023-2024
Oxford Health NHS Foundation Trust
2023-2024
University of Bath
2024
King's College London
2011-2024
Medway School of Pharmacy
2024
University of Nottingham
2024
The London College
2024
University of Otago
2024
Automated delivery of psychological therapy using immersive technologies such as virtual reality (VR) might greatly increase the availability effective help for patients. We aimed to evaluate efficacy an automated VR cognitive (gameChange) treat avoidance and distress in patients with psychosis, analyse how whom it work.
Self-harm and eating disorders share multiple risk factors, with onset typically during adolescence or early adulthood. We aimed to examine the incidence rates of these psychopathologies among young people in UK 2 years following COVID-19 pandemic.We conducted a population-based study using primary care electronic health records patients aged 10-24 Clinical Practice Research Datalink (CPRD). The observation period was from Jan 1, 2010, March 31, 2022. calculated monthly self-harm according...
BackgroundThere is a large clinical need for improved treatments patients with persecutory delusions. We aimed to test whether new theoretically driven cognitive therapy (the Feeling Safe Programme) would lead reductions in delusions, above non-specific effects of therapy. also treatment effect mechanisms.MethodsWe did parallel, single-blind, randomised controlled trial the Programme against befriending same therapists persistent delusions context non-affective psychosis diagnoses. Usual...
Mental health problems bring substantial individual, community and societal costs the need for innovation to promote good mental prevent treat has never been greater. However, we know that research findings can take up 20 years implement. One way push pace is focus researchers funders on shared, specific goals targets. We describe a consultation process organised by Department of Health Social Care convened Chief Medical Officer consider high level future efforts begin identify UK-specific...
Many patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, anxiety or negative-self beliefs. lead to withdraw activities, and this isolation leads a cycle of worsening physical mental health. Breaking requires highly active treatment directly in the troubling so that learn they safely confidently enter them. However seldom receive such life-changing interventions. To solve problem we have developed...
Sleep disturbance is common and problematic for young people at ultra-high risk of psychosis. disruption a contributory causal factor in the occurrence mental health problems, including psychotic experiences, anxiety, depression. The implication that treating sleep problems might have additional benefits on outcomes individuals high risk. present study had two aims: first, to establish feasibility acceptability randomised controlled trial treat with aim reducing experiences psychosis;...
Abstract Background Given the rapid expansion of research into digital health interventions (DHIs) for severe mental illness (SMI; eg, schizophrenia and other psychosis diagnoses), there is an emergent need clear safety measures. Currently, measurement reporting adverse events (AEs) are inconsistent across studies. Therefore, international network, iCharts, was assembled to systematically identify refine a set standard operating procedures (SOPs) AE in DHI studies SMI. Design The iCharts...
Abstract Background Rapid weight gain is common with antipsychotic medication. Lost confidence, low mood and medication non‐adherence often follow. Yet, the dynamic interactions between physical psychological consequences of gain, implications for intervention, are unknown. Objectives We examined first‐person accounts to identify preferences change interventions. Design A qualitative design was used explore patients’ experiences in context psychosis. Method Semi‐structured interviews,...
Automated virtual reality (VR) therapy has the potential to substantially increase access evidence-based psychological treatments. The results of a multicenter randomized controlled trial showed that gameChange VR cognitive reduces agoraphobic avoidance people diagnosed with psychosis, especially for those severe avoidance.We set out use peer research approach explore participants' experiences therapy. This in-depth experiential exploration user experience may inform implementation in...
Automated virtual reality therapies are being developed to increase access psychological interventions. We assessed the experience with one such therapy of patients diagnosed psychosis, including satisfaction, side effects, and positive experiences technology. tested whether effects affected therapy.In a clinical trial 122 psychosis completed baseline measures psychiatric symptoms, received gameChange VR therapy, then satisfaction questionnaire, Oxford-VR Side Effects Checklist, outcome...
This paper describes how participatory design was employed in the of an automated Virtual Reality (VR) psychological therapy (gameChange), putting people with lived experience psychosis at heart process. Solutions to complex challenges invariably need include expertise and ideas specialists from a broad variety disciplines experiences. The gameChange relied on insights clinical psychologists, programmers, animators, designers, product managers, producers, writers, researchers, 3 D artists,...
An automated virtual reality cognitive therapy (gameChange) has demonstrated its effectiveness to treat agoraphobia in patients with psychosis, especially for high or severe anxious avoidance. Its economic value the health care system is not yet established.
Cognitive Bias Modification for paranoia (CBM-pa) is a novel, theory-driven psychological intervention targeting the biased interpretation of emotional ambiguity associated with paranoia. Study objectives were (i) test intervention's feasibility, (ii) provide effect size estimates, (iii) assess dose-response and (iv) select primary outcomes future trials.In double-blind randomised controlled trial, sixty-three outpatients clinically significant to either CBM-pa or an active control (text...
Background Paranoia is a highly debilitating mental health condition. One novel intervention for paranoia cognitive bias modification (CBM-pa). CBM-pa comes from class of interventions that focus on manipulating interpretation bias. Here, we aimed to develop and evaluate new therapy content later use in self-administered digital therapeutic called STOP (“Successful Treatment Paranoia”). Objective This study (1) take user-centered approach with input living experts, clinicians, academics...
Background Patients diagnosed with psychosis often spend less time than others engaged in exercise and more sitting down, which likely contributes to poorer physical mental health. Objective The aim of this study was develop a comprehensive framework from the perspective patients, carers, staff for understanding what promotes movement activity. Methods A critical realist approach taken design study. Interviews (n=23) focus groups (n=12) were conducted (1) outpatients aged 16 years or older...
Adverse events (AEs) are commonly reported in clinical studies using the Medical Dictionary for Regulatory Activities (MedDRA), an international standard drug safety monitoring. However, technical language of MedDRA makes it challenging patients and clinicians to share understanding therefore make shared decisions about medical interventions. In this project, people with lived experience depression antidepressant treatment worked researchers co-design online dictionary AEs associated...
Persecutory delusions are the most common type of in psychosis and present around 10–15% general population. thought to be sustained by biased cognitive emotional processes. Recent advances favour targeted interventions, focussing on specific symptoms or mechanisms. Our aim is test clinical feasibility a novel psychological intervention, which manipulates interpretations toward more adaptive processing, order reduce paranoia patients. The 'Cognitive Bias Modification for paranoia' (CBM-pa)...