A5044872102- Schizophrenia research and treatment
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Psychiatry
- Mental Health Treatment and Access
- Digital Mental Health Interventions
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Dementia and Cognitive Impairment Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Music Perception
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Bipolar Disorder and Treatment
- Psychosomatic Disorders and Their Treatments
- Suicide and Self-Harm Studies
- Mental Health and Patient Involvement
- EEG and Brain-Computer Interfaces
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Health, Environment, Cognitive Aging
- Health Policy Implementation Science
- Treatment of Major Depression
University of California, San Diego
2016-2025
VA San Diego Healthcare System
2015-2024
University of California System
2006-2023
Institute on Aging
2023
Zucker Hillside Hospital
2022
Northwell Health
2022
San Diego State University
2017-2021
UC San Diego Health System
2017-2020
Universidad Católica Santo Domingo
2018-2020
Centre National de la Recherche Scientifique
2010
Abstract Episodic (recall of passages) and semantic (letter category fluency) memory tasks were administered to Alzheimer's Disease (early stages), Huntington's (HD), alcoholic Korsakoff patients matched for overall severity dementia. Although all three patient groups severely (and equally) impaired on passages, only the Alzheimer emitted numerous intrusion errors. On fluency tasks, performance mild was distinguishable from that other two groups. both HD demonstrated severe moderate...
The present study examined associations between alcohol involvement in early to middle adolescence and neuropsychological (NP) functioning.Alcohol-dependent adolescents (n = 33) with over 100 lifetime episodes without dependence on other substances were recruited from alcohol/drug abuse treatment facilities. Comparison 24) had no histories of or drug problems matched alcohol-dependent participants age (15 16 years), gender, socioeconomic status, education, family history dependence. NP tests...
Abstract Cognitive task‐evoked pupillary responses reliably index information‐processing loads. However, previous studies have reported inconsistent findings regarding the nature of response when processing demands approach or exceed available resources. This condition was examined in 22 normal undergraduates by using pupillometric recordings during a digit span recall task, with 5 (low load), 9 (moderate and 13 (excessive load) digits per string. Pupillary increased systematically load...
Mobile Assessment and Treatment for Schizophrenia (MATS) employs ambulatory monitoring methods cognitive behavioral therapy interventions to assess improve outcomes in consumers with schizophrenia through mobile phone text messaging. Three MATS were developed target medication adherence, socialization, auditory hallucinations. Participants received up 840 messages over a 12-week intervention period. Fifty-five or schizoaffective disorder enrolled, but 13 more severe negative symptoms, lower...
Mobile devices can be used to deliver psychosocial interventions, yet there is little prior application in severe mental illness. We provide the rationale, design, and preliminary data from 3 ongoing clinical trials of mobile interventions developed for bipolar disorder or schizophrenia. Project 1 a personal digital assistant prompt engagement personalized self-management behaviors based on real-time data. 2 employed experience sampling through text messages facilitate case management. was...
MindScape aims to study the benefits of integrating time series behavioral patterns (e.g., conversational engagement, sleep, location) with Large Language Models (LLMs) create a new form contextual AI journaling, promoting self-reflection and well-being. We argue that sensing in LLMs will likely lead frontier AI. In this Late-Breaking Work paper, we discuss journal App design uses generate personalized journaling prompts crafted encourage emotional development. also college students based on...
OBJECTIVE: The number of older patients with chronic schizophrenia is increasing. There a need for empirically validated psychotherapy interventions these patients. Cognitive behavioral social skills training teaches cognitive and coping techniques, functioning skills, problem solving, compensatory aids neurocognitive impairments. authors compared treatment as usual the combination plus training. METHOD: randomized, controlled trial included 76 middle-aged outpatients schizophrenia, who were...
This study prospectively examined neuropsychological (NP) functioning associated with adolescent substance use and withdrawal. Participants were youths histories of disorders ( n = 47) demographically comparable no such lifetime 26). They followed NP testing involvement interviews at 7 time points spanning 8 years, from ages 16 to 24, on average. After controlling for recent use, age, education, practice effects, baseline functioning, over the 8-year follow-up period significantly predicted...
Background: Computerized Ecological Momentary Assessment (EMAc) techniques permit the assessment of daily life behaviors and experiences. The present investigation examined feasibility validity this methodology in outpatients with schizophrenia. Methods: Outpatients schizophrenia or schizoaffective disorder (n = 54) received a battery standard laboratory clinical functional outcome measures then completed electronic questionnaires on personal digital assistant (PDA) microcomputer 4 times per...
Negative symptoms are associated with a range of poor clinical outcomes, and currently available treatments generally do not produce clinically meaningful response. Limited treatment progress may be owing in part to clarity regarding latent structure. Prior studies have inferred structure using exploratory factor analysis, which has led the conclusion that there 2 dimensions reflecting motivation pleasure (MAP) diminished expressivity (EXP) factors. However, whether these conclusions...
Identifying treatments to improve functioning and reduce negative symptoms in consumers with schizophrenia is of high public health significance.In this randomized clinical trial, participants or schizoaffective disorder (N = 149) were randomly assigned cognitive behavioral social skills training (CBSST) an active goal-focused supportive contact (GFSC) control condition. CBSST combined behavior therapy problem-solving symptoms. GFSC was weekly group focused on setting achieving goals. Blind...
Task-evoked pupillary responses may be a psychophysiological biomarker of early risk for mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Pupil dilation during tasks reflects effort until compensatory capacity is surpassed performance declines are manifest, activation in the locus coeruleus, where degenerative changes have been found earliest stages AD. We recorded digit span recall 918 participants ages 56–66. Despite normal performance, amnestic single-domain MCI (S-MCI)...
Abstract Schizophrenia is a major cause of disability worldwide. As new treatments for functioning are tested, the need grows to demonstrate real-world gains. Ecological momentary assessment (EMA) may provide more ecologically valid measure functioning. In this study, smartphone-based EMA was used signal participants with schizophrenia (N = 100) and controls 71) 7 times day days respond brief questionnaires about social interactions behaviors. Excellent adherence found, both groups...
Abstract Mobility is an important correlate of physical, cognitive, and mental health in chronic illness, can be measured passively with mobile phone global positional satellite (GPS) sensors. To date, GPS data have been reported a few studies schizophrenia, yet it unclear whether these concurrent momentary reports location, vary by people schizophrenia healthy comparison subjects, or associate symptom clusters schizophrenia. A total 142 participants ( n = 86) subjects 56) completed 7 days...
Abstract Introduction The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). LC is implicated regulating the sleep–wake cycle, modulating cognitive function, and AD progression. Methods Participants were 481 men (ages 62 to 71.7) from Vietnam Era Twin Study of Aging. structural integrity was indexed by neuromelanin‐sensitive magnetic resonance imaging (MRI) contrast‐to‐noise ratio (LC CNR ). We examined , cognition, amnestic mild impairment (aMCI),...
Patterns of brain activation associated with covert performance the Stroop Color-Word task were studied in young, healthy, adult volunteers using blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Comparisons incongruous condition made both color naming and word reading baselines. Areas left right anterior cingulate, precuneus, pars opercularis displayed larger BOLD signal responses during than baseline conditions. Activation signals these areas was highly...