A5101805527- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Aging and Gerontology Research
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Stress Responses and Cortisol
- Psychosomatic Disorders and Their Treatments
- Pain Management and Treatment
- Spaceflight effects on biology
- Mental Health Treatment and Access
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Psychological Well-being and Life Satisfaction
University of Hong Kong
2016-2025
HKU-Pasteur Research Pole
2025
Chinese University of Hong Kong
2020-2023
King's College London
2020-2022
Tseung Kwan O Hospital
2013-2014
Hospital Authority
2014
Cognitive bias modification for interpretation (CBM-I) is an effective low-intensity intervention that targets biases associated with the development and maintenance of social anxiety. Few studies to-date have examined extent to which individual mental imagery ability affects efficacy CBM-I. A total 666 individuals were screened. Seventy-two participants high levels anxiety elevated baseline randomly assigned either CBM-I (n = 36) or control groups 36). They completed 5-day...
Cognitive Bias Modification for paranoia (CBM-pa) is a novel, theory-driven psychological intervention targeting the biased interpretation of emotional ambiguity associated with paranoia. Study objectives were (i) test intervention's feasibility, (ii) provide effect size estimates, (iii) assess dose-response and (iv) select primary outcomes future trials.In double-blind randomised controlled trial, sixty-three outpatients clinically significant to either CBM-pa or an active control (text...
ABSTRACT Background: The high prevalence of mild cognitive impairment (MCI) in Hong Kong, as previously reported, requires verification. Furthermore, the relationship between loneliness, depression, and with regards to MCI are unclear. present study aims establish a community sample Kong determine if participants feel significantly lonelier, even after depression has been taken into consideration. Methods: Participants from ( N = 376) were assessed subjective objective measures impairments...
General cognitive status (GCS) is a composite of abilities reflecting full function. The literature suggests relationship between processing speed and GCS, as well age-related changes on performance. Therefore, this study recruited 34 younger 39 older adults to verify differences in relationships GCS. We measured with the Processing Speed Index Wechsler Adult Intelligence Scale. Findings indicated that predicted GCS but not adults. Future research may be needed training effect This also...
Background: There is no valid instrument for multidomain cognitive assessment to aid the detection of mild impairment (MCI) and dementia in Hong Kong. This study aimed validate Cantonese Addenbrooke’s Cognitive Examination Revised (C-ACER) identification MCI dementia. Methods: 147 participants (Dementia, n = 54; MCI, 50; controls, 43) aged 60 or above were assessed by a psychiatrist using C-ACER. The C-ACER scores validated against expert diagnosis according DSM-IV criteria Petersen MCI....
A school-based survey was conducted to examine the impact of parental gambling on adolescent behavior and mental health status. self-administered standardized questionnaire distributed 1,095 high school students. The response rate 84.5%. Almost half participants (46.5%) reported in past year. Using DSM-IV-MR-J (Journal Gambling Studies 16: 253-273, 2000), 3.3% (n = 31) could be identified as at-risk gamblers, 0.9% 8) classified probable pathological gamblers. Only 16.7% 155) disclosed having...
The relationship between depression, loneliness, and cognitive functioning among the elderly is not well understood in literature. In present study, we tested moderating influence of depressive symptoms on loneliness functioning. We recruited 100 community-dwelling older adults Hong Kong. Demographic information, perceived depressed mood, general status were assessed. Results indicated that married participants reported lower levels (t (96) = 2.26, p .03). found a significant effect (B −.05,...
Abstract Objective: Findings from single-session online studies highlighted the potential of using anodal prefrontal transcranial direct current stimulation (tDCS) to enhance executive functions (EF) in context aging. However, tDCS must be executed as a multi-session offline intervention ascertain its viability this context. Relatedly, findings remained inconclusive. To end, we examined effects on EF an intervention. Method: The consisted 15 sessions; each, healthy older participants (Age...
Increasing evidence has shown that positive affect enhances many aspects of daily functioning. Yet, how dispositional is represented in the intrinsic brain networks remains unclear. Here, we used resting-state functional Magnetic Resonance Imaging to test trait and negative an individual were associated with connectivity regions within salience emotion network default mode 70 healthy young adults. We observed was negatively network, particularly bidirectional connections spanning left...
Moyamoya disease is a rare cerebrovascular disorder associated with cognitive dysfunction. It usually treated by surgical revascularization, but research on the neurocognitive outcomes of revascularization surgery controversial. Given that impairment could affect daily activities patients moyamoya disease, early detection postoperative has potential to improve patient management. In this study, we applied well-established connectome-based predictive modelling approach develop machine...
Late-life depression is common among older adults. Although white-matter abnormality highly implicated, the extent to which corticospinal tract associated with pathophysiology of late-life unclear. The current study aims investigate structural integrity and determine its cognitive functional correlates in adults depression. Twenty-eight clinical 23 healthy age-matched participated study. white matter volume hyperintensities (WMHs) tract, as well global WMHs, were measured. Psychomotor...
Most studies investigating the neural correlates of threat learning were carried out using an explicit Pavlovian conditioning paradigm where declarative knowledge on contingencies between conditioned (CS) and unconditioned stimuli (US) is acquired. The current study aimed at understanding when contingency awareness limited or even absent.We conducted fMRI report in implicit associative called multi-CS conditioning, which a number faces associated with aversive screams such that participants...
Background and Objectives: The role of interpretation bias in generating maintaining persecutory beliefs/paranoid ideation is becoming established the literature, but how negative mood affects this relationship remains unclear. current study investigated mediating anxiety depression association between paranoia patients with persistent paranoia.Methods/Design: We applied mediation model to clinical data gathered from (N = 62), compared levels affected paranoia.Results: Interpretation...
Abstract Anxiety and fear-related disorders are among the most prevalent mental illnesses. Non-invasive brain stimulation methods such as transcranial direct current (tDCS) magnetic (TMS) have been employed to modulate anxiety symptoms, but their therapeutic effects remain inconclusive. Pavlovian conditioning extinction experimental analogues of exposure therapy that investigate neural mechanisms fear return fear. We conducted a meta-analysis qualitative review on tDCS TMS in non-primate...
Extinction learning is regarded as a core mechanism underlying exposure therapy. The extent to which learned threats can be extinguished without conscious awareness controversial and on-going debate. We investigated whether implicit vs. explicit threatened stimulus modulate defence responses measured using pupillometry. Healthy participants underwent threat conditioning paradigm in one of the conditioned stimuli (CS) was perceptually suppressed continuous flash suppression (CFS)....