A5043413507- Global Maternal and Child Health
- Intimate Partner and Family Violence
- Stress Responses and Cortisol
- Homicide, Infanticide, and Child Abuse
- S100 Proteins and Annexins
- Child and Adolescent Psychosocial and Emotional Development
- Hormonal Regulation and Hypertension
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Birth, Development, and Health
- Nerve injury and regeneration
- Adrenal Hormones and Disorders
- Ichthyology and Marine Biology
- Sport Psychology and Performance
- Physical Activity and Health
- Pain Management and Placebo Effect
- Nuclear Receptors and Signaling
- Schizophrenia research and treatment
- Wound Healing and Treatments
- Cell Adhesion Molecules Research
- Intensive Care Unit Cognitive Disorders
- Renin-Angiotensin System Studies
Manchester Metropolitan University
2018-2023
University of Aberdeen
2003-2020
University of Manchester
1985-2019
Manchester Academic Health Science Centre
2017-2019
Universidade Federal de Pernambuco
2019
NIHR Manchester Biomedical Research Centre
2017-2018
Health Sciences Centre
2017
Stanford University
2009-2015
University of Salford
2014
PharmacoGenetics (China)
2010-2013
Background: Elevated biomarkers of systemic inflammation have been reported in individuals with cognitive decline, however, most the literature concerns cross-sectional analyses that produced mixed results. This study investigates etiology this association by performing meta-analyses on prospective studies investigating relationship between baseline interleukin-6 (IL-6), an established marker peripheral inflammation, decline risk non-demented adults at follow-up. Methods: We reviewed...
Abstract Stopping smoking is difficult even with treatment. Many patients prescribed pharmacologic treatments for cessation experience side effects or lack of efficacy. We performed a pharmacogenetic study the efficacy and tolerability bupropion transdermal nicotine (TN), two cessation. Samples were drawn from studies. In first (Maintenance 1, MT1), 301 smokers received plus TN 11 weeks, followed by 14 weeks placebo bupropion. second (MT2), 276 8 weeks. focused on eight SNPs in 15q24 region,...
Variation in the ATP-binding cassette, subfamily B, member 1 transporter (ABCB1) (multidrug-resistance gene 1) has been investigated as a predictor of response to treatment with variety medications such antiarrhythmics, chemotherapeutic agents, anti-HIV medications, and some psychotropics. The ABCB1 product, P-glycoprotein, affects transport drugs out many cell types, including endothelial cells at blood-brain barrier. We sought determine if polymorphisms predict antidepressant geriatric...
Several lines of evidence support the involvement disrupted in schizophrenia 1 (DISC1) gene susceptibility, including its original identification a family with chromosome translocation, several genetic association studies, and functional characterization product. In present study, we have genotyped multiple SNP microsatellite markers large Scottish case-control sample. We identified two SNPs one that show significant schizophrenia. The strongest is haplotype rs751229 rs3738401, located at 5'...
Abstract Genetic variation at the FKBP5 locus has been reported to affect clinical outcomes in patients treated with antidepressant medications several studies. However, other reports have not confirmed this association. may regulate sensitivity of hypothalamic–pituitary–adrenal axis. We tested two single nucleotide polymorphisms (rs1360780 and rs3800373) a sample 246 geriatric for 8 weeks double‐blind randomized comparison trial paroxetine mirtazapine. These had previously predict efficacy...
Aim Brain-derived neurotrophic factor (BDNF) is associated with antidepressant response on the cellular level, in animal models, and clinical studies. A common variant BDNF gene results a substitution of methionine (Met) for valine at amino acid position 66. Previous studies reported that Met enhanced to medications. These findings may be odds indicating level impairs secretion BDNF. Materials methods We examined effects single nucleotide polymorphisms (SNPs) antidepressants paroxetine...
The prevalence of antidepressant prescribing in children and adolescents increased steadily the United States parts Europe between 2005 2012 despite regulatory safety warnings. Little is known about characteristics those being prescribed antidepressants for first time.A longitudinal study 3-17 year olds was carried out using data from UK Clinical Practice Research Datalink (CPRD) 2000 2015. Changes incidence ever prescriptions them examined.Incidence nearly doubled 2006 2015 rising 1.60...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 521:171-187 (2015) - DOI: https://doi.org/10.3354/meps11138 Genetic and migratory evidence for sympatric spawning of tropical Pacific eels from Vanuatu Robert Schabetsberger1,*, Finn Økland2, Donna Kalfatak3, Ursula Sichrowsky4, Meelis Tambets5, Kim Aarestrup6, Chrysoula Gubili7,10, Jane Sarginson7, Belgees...
Abstract Migratory movements in response to seasonal resources often influence population structure and dynamics. Yet mobile marine predators, genetic consequences of such repetitious behaviour remain inaccessible without comprehensive sampling strategies. Temporal seasonally recurring aggregations planktivorous basking sharks, Cetorhinus maximus , the Northeast Atlantic (NEA) affords an opportunity resolve individual re-encounters at key sites with connectivity patterns relatedness. Genetic...
Low GABA transmission has been reported in suicide, and GABRA6 rs3219151 T allele associated with greater physiological endocrine stress response previous studies. Although environmental also plays a role the possible of this not investigated respect. In our present study effect gene interaction recent negative life events on lifetime current depression, anxiety, as well suicide were using regression models white European general sample 2283 subjects. Post hoc measures for phenotypes related...
Current treatments for smoking cessation have limited efficacy. A potential pharmaceutical treatment is selegiline, a selective and irreversible monoamine oxidase B inhibitor. few clinical trials been carried out using selegiline but the results mixed. We sought to determine if genetic markers in cholinergic loci 15q24 chromosomal region predict response therapy with selegiline. performed an 8-week double-blind, placebo-controlled trial of transdermal system heavy smokers, follow-up at weeks...
The at-risk mental state (ARMS) describes individuals at high risk of developing schizophrenia or psychosis. use antipsychotics in this population is not supported, because most with ARMS are unlikely to develop Anti-inflammatory treatments and polyunsaturated fatty acids (PUFAs) may have some beneficial effects the treatment ARMS. There been no controlled clinical trials which researchers investigated minocycline for involving PUFAs combination other proposed treatments. a need find...
Sleep disruption (SD) increases sympathetic activity and cortisol secretion, delays cognitive functions such as reaction-time (RT). Sympathetic of disturbed sleepers, is similar to those so-called decision-reinvesters. Decision-reinvestment refers traits in individuals with greater tendency ruminate reinvest their decisions, significant decrease both motor-control performance. Decision-making quality a crucial attribute athletic performance which relies on RT. Consequently, SD affects...
<ns4:p><ns4:bold>Background: </ns4:bold>Intimate partner violence (IPV) is a risk factor for developmental problems in offspring. Despite high prevalence of IPV the UK and elsewhere, longer-term outcomes offspring born to exposed mothers remain under-researched.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>Population-based cohort study. We assessed by type timing 3,153 mother-child pairs with complete data within our study population examined associations between IQ. used multiple-imputation...
Journal Article A Reliable Method of Inducing Placebo Analgesia in Volunteers Get access Jane E Sarginson, Sarginson Department Pharmacology, University Manchester, Manchester M13 9PT Search for other works by this author on: Oxford Academic Google Scholar J M H Rees Pharmacy and Volume 37, Issue Supplement_12, December 1985, Page 105P, https://doi.org/10.1111/j.2042-7158.1985.tb14177.x Published: 12 April 2011