A5100345923- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Colorectal and Anal Carcinomas
- Atherosclerosis and Cardiovascular Diseases
- Flavonoids in Medical Research
- Liver Disease and Transplantation
- Sphingolipid Metabolism and Signaling
- Nerve injury and regeneration
- Blood Coagulation and Thrombosis Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Eicosanoids and Hypertension Pharmacology
- Bone fractures and treatments
- Traditional Chinese Medicine Analysis
- Endoplasmic Reticulum Stress and Disease
- Trauma and Emergency Care Studies
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Influenza Virus Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis C virus research
- Stroke Rehabilitation and Recovery
- Monoclonal and Polyclonal Antibodies Research
- Pneumocystis jirovecii pneumonia detection and treatment
Neijiang Normal University
2025
Zhuhai People's Hospital
2018-2023
Jinan University
2018-2023
Beijing Chuiyangliu Hospital
2022
First Affiliated Hospital of Zhengzhou University
2021
Xichang University
2021
Zhongda Hospital Southeast University
2018
University of California, Davis
2016
The University of Texas Health Science Center at Houston
2016
University of Maryland, Baltimore
2016
BACKGROUND The Mangled Extremity Severity Score (MESS) was developed 25 years ago in an attempt to use the extent of skeletal and soft tissue injury, limb ischemia, shock, age predict need for amputation after extremity injury. Subsequently, there have been mixed reviews as this score. We hypothesized that MESS, when applied a data set collected prospectively modern times, would not correlate with amputation. METHODS MESS patient American Association Surgery Trauma PROspective Vascular...
Acute ischaemic stroke (AIS) is a highly heterogeneous disorder and warrants further investigation to stratify patients with different outcomes treatment responses. Using large-scale registry cohort, we applied data-driven approach identify novel phenotypes based on multiple biomarkers.In nationwide, prospective, 201-hospital study taking place in China between August 01, 2015 March 31, 2018, the AIS who were over 18 years of age admitted hospital within 7 days from symptom onset included....
The purpose of this study is to investigate the protective effect γ-oryzanol (ORY) against hepatic ischemia reperfusion (HIR) injury and potential mechanisms ORY. ORY an important biologically active ingredient isolated from rice bran oil, which has anti-inflammatory antiapoptotic effects. However, it still unknown whether can protect liver HIR damage. In study, was administered orally for seven days, after animals were subjected 60 minutes reperfused 6 hours. Related indicators analyzed....
Sulfonylureas have been regarded as potential drug candidates against tuberculosis (TB) because they can inhibit the biosynthesis of branched-chain amino acids by targeting acetohydroxyacid synthase (AHAS). We demonstrated previously that novel monosubstituted sulfonylureas showed potent in vitro activities TB. In current study, we further explored anti-TB activity a mouse model. Compounds 30 and 31 exhibited most efficacy: single intragastric administration at dose 250 mg/kg led to reduced...
Thrombolytic stroke therapy with tissue plasminogen activator (tPA) is limited by risks of hemorrhagic transformation (HT). We have reported that a new 12/15-lipoxygenase (12/15-LOX) inhibitor ML351 reduced tPA related HT in mice subjected to experimental under anticoagulation. In this study, we asked whether can ameliorate induced an embolic model. Rats were middle cerebral artery occlusion 2 or 3 hr ischemia and infusion, without ML351. Regional blood flow was monitored after continuously...
Although the genetic variability of hepatitis B virus (HBV) in HBV-infected patients has been extensively studied, reports on genotypes, subtypes and mutations S region HBV strains from Chinese blood donors are limited. In this study, 245 samples HBsAg-positive were collected five geographically diverse centers China. The was amplified, genotype subtype determined. amino acid sequences aligned, related to failure immunization HBsAg detection Of samples, 228 (93 %) genotyped successfully. We...
Abstract Introduction Early brain injury (EBI) plays a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). Autophagy and apoptosis may share common molecular inducer that regulates process of cell death. FoxO1, as regulator neuronal autophagy which is involved apoptosis, has not been reported SAH rats. This work was to investigate protective anti‐inflammatory effects FoxO1 on EBI by regulating autophagy. Methods In this study, we constructed model. experiment I, low...
To explore the efficacy of intravenous thrombolysis combined with arterial (bridging therapy) in patients acute cerebral infarction and its effect on serum inflammatory factors.The case data 138 admitted to our hospital from February 2019 2021 were retrospectively analyzed. According treatment plan they received, assigned two groups, namely, an observation group (n = 71) treated bridging therapy a control 67) alone. The following indexes recorded compared between groups: efficacy, National...
Objective To investigate the relationship between children with traumatic cerebral infarction (TCI) and plasma fibrinogen gene polymorphism level. Methods Use method of PCR-RELP to detect -455G/A type in 71 cases 40 without infarction. The levels were detected by CA-530 automatic blood analyzer hospital from January 2003 March 2011. Results Genetype GG allele G Bβ-455G / site group (73. 24% 83.8%) had a higher frequency than that control (45.0% 63. 8%). relative risk genotype Fg- Bβ-455G/A...