A5085436320- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Hippo pathway signaling and YAP/TAZ
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and disorders
- Lung Cancer Treatments and Mutations
- Cellular Mechanics and Interactions
- Pancreatitis Pathology and Treatment
- Ubiquitin and proteasome pathways
- Liver physiology and pathology
- Genomics, phytochemicals, and oxidative stress
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune cells in cancer
- Alcoholism and Thiamine Deficiency
- Caveolin-1 and cellular processes
- Ginger and Zingiberaceae research
- 14-3-3 protein interactions
- Natural Antidiabetic Agents Studies
- Galectins and Cancer Biology
- Microtubule and mitosis dynamics
- Amyotrophic Lateral Sclerosis Research
- Heme Oxygenase-1 and Carbon Monoxide
- Helicobacter pylori-related gastroenterology studies
- Autophagy in Disease and Therapy
Affiliated Hospital of Southwest Medical University
2018-2023
University of Science and Technology of China
2023
In this study, kaempferol (KA) ameliorates APAP-induced hepatotoxicity by activating HO-1/NQO1 and inhibiting HMGB1/TLR4/NF-κB signaling NLRP3 inflammasome activation.
Background . Aloin exerts considerable protective effects in various disease models, and its effect on hepatic ischemia-reperfusion (HIR) injury remains unknown. This research is aimed at conducting an in-depth investigation of the antioxidant, anti-inflammatory, antiapoptosis aloin HIR explain underlying molecular mechanisms. Methods In vivo , different concentrations were intraperitoneally injected 1 h before establishment model male mice. The function, pathological status, oxidative...
Long non-coding RNAs (lncRNAs) play a significant role in multiple human cancers as competing endogenous (ceRNAs). However, systematic mRNA-microRNA (miRNA)-lncRNA network linked to kidney renal clear cell carcinoma (KIRC) prognosis has not been described. In this study, we aimed identify the prognosis-related ceRNA regulatory and analyzed its relationship with immune infiltration predict KIRC patient survival. The MMP25-AS1/hsa-miR-10a-5p/SERPINE1 related of was obtained through...
Accurate and early prognosis of disease is essential to clinical decision making, particularly in diseases, such as HCC, that are typically diagnosed at a late stage the course therefore carry poor prognosis. CDCA5 cell cycle regulatory protein has shown prognostic value several cancers. We retrospectively evaluated 178 patients with HCC treated curative liver resection between September 2009 2012 Nanchong Central Hospital Nanchong, Sichuan Province, China. Patients were screened for their...
The purpose of this study is to investigate the protective effect kaempferol (KAE), main active monomer from Penthorum chinense Pursh, on hepatic ischemia/reperfusion injury (HI/RI) and its specific mechanism. HI/RI a common complication closely related prognosis liver surgery, effective prevention treatment methods are still unavailable. Ischemia/reperfusion (I/R) caused by tissue damage during ischemia sustained oxidative stress inflammation reperfusion. Pursh traditional Chinese medicine...
Abstract Speckle-type POZ domain protein (SPOP), an adaptor in the E3 ubiquitin ligase complex, recognizes substrates and promotes degradation via ubiquitin-proteasome system. It appears to help regulate progression of several cancers, we show here that it acts as a tumor suppressor pancreatic cancer. Our analysis patient tissues showed decreased SPOP expression, which was associated with poor prognosis. knockdown SW1990 (in vitro/vivo) PANC-1 vitro) cells led significantly greater...
Alcoholic liver disease (ALD), a type of chronic that is prevalent worldwide, still identified to have poor prognosis despite many medical treatment protocols. Thus, it urgent develop and test new protocols for ALD. Lactobacillus reuteri (L. reuteri) has been widely used in the clinical digestive system diseases, but studies on protective effect L. ALD are considered be rare. Therefore, present study, we examined provide data significant development An model established C57BL/6J mice treated...
Liver fibrosis refers to the excessive buildup of extracellular matrix (ECM) components in liver tissue. It is considered a pathological response damage for which there no effective treatment. Aloin, an anthraquinone compound isolated from aloe plant, has shown good pharmacological effects treatment gastric cancer, ulcerative colitis, myocardial hypertrophy, traumatic brain injury, and other diseases; however, its specific impact on remains unclear. To address this gap, we conducted study...
Selective rationalizations improve the explainability of neural networks by selecting a subsequence input (i.e., rationales) to explain prediction results. Although existing methods have achieved promising results, they still suffer from adopting spurious correlations in data (aka., shortcuts) compose rationales and make predictions. Inspired causal theory, this paper, we develop an interventional rationalization (Inter-RAT) discover rationales. Specifically, first analyse causalities among...
The purpose of this study is to investigate the protective effect γ-oryzanol (ORY) against hepatic ischemia reperfusion (HIR) injury and potential mechanisms ORY. ORY an important biologically active ingredient isolated from rice bran oil, which has anti-inflammatory antiapoptotic effects. However, it still unknown whether can protect liver HIR damage. In study, was administered orally for seven days, after animals were subjected 60 minutes reperfused 6 hours. Related indicators analyzed....
Hepatocellular carcinoma (HCC) is a common malignancy that driven by multiple genes and pathways. The aim of this study was to investigate the role specific mechanism actin-interacting protein zyxin (ZYX) in HCC. We found expression ZYX significantly higher HCC tissues compared normal liver tissues. In addition, overexpression hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration invasion, whereas knockdown had opposite effects (SK HEP-1, Huh-7). Furthermore, change...
Abstract Hepatic ischemia–reperfusion injury (HIRI) is of common occurrence during liver surgery and transplantation. Pinocembrin (PIN) a kind flavonoid monomer extracted from the local traditional Chinese medicine Penthorum chinense Pursh (P. chinense). However, effect PIN on HIRI has not determined. We investigated protective potential mechanism against HIRI. Model mice were subjected to partial ischemia for 60 min, experimental pretreated with orally 7 days, H 2 O ‐induced oxidative...
Abstract Chronic pancreatitis (CP), characterized by pancreatic fibrosis, is a recurrent, progressive and irreversible disease. Activation of the stellate cells (PSCs) considered core event in fibrosis. In this study, we investigated role hydrogen peroxide‐inducible clone‐5 (Hic‐5) CP. Analysis human tissue samples revealed that Hic‐5 was overexpressed patients with CP extremely low healthy pancreas. significant up‐regulated activated primary PSCs independently from transforming growth...
The survival of motor neuron (SMN) protein is ubiquitously involved in spliceosome assembly and ribonucleoprotein biogenesis. SMN expressed kidney can affect cell death processes. However, the role acute injury (AKI) largely unknown. In current study, we found that expression was significantly reduced both clinical ischemic AKI a mouse model renal ischemia-reperfusion (IRI). We then used heterozygous knockout (SMN+/-) mice declines function, tubular injury, apoptosis after experimental IRI...
Previous retrospective studies have suggested that surufatinib is effective for treating advanced solid tumors; however, the efficacy and safety of this drug needs to be investigated further via high-quality evidence or randomized controlled trials. In present study, a meta-analysis was carried out evaluate effectiveness patients with tumors. Systematic, electronic literature searches were conducted using PubMed, EMBASE, Cochrane Library ClinicalTrials.gov. The disease control rate (DCR) in...
Background: Inducible nitric oxide synthase (iNOS) and vascular endothelial dysfunction are implicated in the development progression of atherosclerosis. This study aimed to elucidate underlying mechanism iNOS dysfunction.Methods: UPLC/QTOF-MS combined with multivariate data analysis was used characterize metabolite changes human umbilical vein cells (HUVECs) under different treatments. Moreover, molecular biology techniques were applied mechanisms role dysfunction.Results: TNF-α could...
Abstract To investigate the regulatory effect and specific mechanism of actin-interacting protein zyxin (ZYX) in hepatocellular carcinoma (HCC). HCC is one most common malignant tumors world which occurrence development areregulated by multiple genes. We found that expression ZYX tissues was significantly higher than normal liver tissues. The results cell proliferation assay, scratch test transwell assay showed high promoted proliferation, migration invasion hepatoma lines (PLC/PRF/5,...