A5100336213- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Biomedical Text Mining and Ontologies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Proteoglycans and glycosaminoglycans research
- Machine Learning in Healthcare
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Wnt/β-catenin signaling in development and cancer
- Topic Modeling
- Microtubule and mitosis dynamics
- Angiogenesis and VEGF in Cancer
- Liver physiology and pathology
- Heat shock proteins research
Nantong University
2016-2025
Qinghai New Energy (China)
2025
CHN Energy (China)
2025
Hebei University of Engineering
2017-2025
First People's Hospital of Yunnan Province
2025
Kunming University of Science and Technology
2025
Southwest Medical University
2011-2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Gansu Provincial Hospital
2024
Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile-acid synthesis by reducing the expression levels genes encoding key synthetic enzymes (e.g., cytochrome P450 [CYP]7A1/Cyp7a1 and CYP8B1/Cyp8b1). FXR-mediated induction hepatic small heterodimer partner (SHP/Shp, Nr0b2) intestinal fibroblast growth factor 15 (Fgf15; FGF19 humans) has been shown to be responsible for this suppression. However, exact contribution Shp/Fgf15 suppression, associated...
Background Centromere protein A (CENP-A) plays important roles in cell-cycle regulation and genetic stability. Herein, we aimed to investigate its expression pattern, clinical significance, biological function hepatocellular carcinoma (HCC). Methodology/Principal Findings CENP-A at the mRNA levels was examined 20 pairs of fresh HCCs corresponding nontumor liver tissues. Immunohistochemistry for performed on 80 paraffin-embedded HCC specimens, significance analyzed. human cell line HepG2 with...
Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion Murine Lymphomas 2 (PIM2) directly bound to and phosphorylated on Thr473. Biochemical analyses demonstrated Thr473 promoted its protein stability through chaperone-mediated autophagy (CMA) pathway, levels PIM2 pThr473-HK2 proteins were positively correlated...
Abstract Bile acid (BA) metabolism is tightly controlled by nuclear receptor signaling to coordinate regulation of BA synthetic enzymes and transporters. Here we reveal a molecular cascade consisting the antiapoptotic protein BCL2, Shp long non-coding RNA (lncRNA) H19 maintain homeostasis. Bcl2 was overexpressed in liver C57BL/6J mice using adenovirus mediated gene delivery for two weeks. Hepatic overexpression caused drastic accumulation serum bilirubin levels dysregulated reactivation...
Pneumonia is a common complication after stroke, causing an increased length of hospital stay and death. Therefore, the timely accurate prediction post-stroke pneumonia would be highly valuable in clinical practice. Previous risk score models were often built on simple statistical methods such as logistic regression. This study aims to investigate using more advanced machine learning algorithms, specifically deep approaches.Using hospital's electronic health record(EHR) data from 2007-2017,...
A correction to this paper has been published and can be accessed via a link at the top of paper.
The AI-based small molecule drug discovery has become a significant trend at the intersection of computer science and life sciences. In pursuit novel compounds, fragment-based emerged as approach. Generative Pre-trained Transformers (GPT) model showcased remarkable prowess across various domains, rooted in its pre-training representation learning fundamental linguistic units. Analogous to natural language, molecular encoding, form chemical necessitates fragmentation aligned with specific...
Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 reported to be overexpressed in multiple cancers. The clinical significance biological role pancreatic cancer, however, remain established.GPR87 expression cell lines, paired patient tissues were determined using western blotting Real-time PCR. Ninety-six human tissue samples analyzed by immunochemistry (IHC) investigate association between clinicopathological...
Glioblastoma (GBM) is the most common and deadly primary brain tumor in adults. Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), can attenuate tumor-associated edema improve patient symptoms but based on magnetic resonance imaging, associated with non-enhancing progression possibly gliosarcoma differentiation. To gain insight into these findings, we investigated role of hypoxia epithelial-mesenchymal transition (EMT)-associated proteins GBM....
Heat shock transcription factor 1 (HSF1) is the master regulator of proteotoxic stress response, which plays a key role in breast cancer tumorigenesis. However, mechanisms underlying regulation HSF1 protein stability are still unclear. Here, we show that regulated by PIM2-mediated phosphorylation at Thr120, disrupts binding to E3 ubiquitin ligase FBXW7. In addition, Thr120 promoted proteostasis and carboplatin-induced autophagy. Interestingly, induced PD-L1 promoter enhanced expression....
The objective of this study was to evaluate the clinical consistency new World Health Organization 2010 grading and European Neuroendocrine Tumor Society 2006 TNM staging systems on surgical outcome for patients with pancreatic neuroendocrine tumors (p-NETs). Moreover, we will discuss their prognostic value.The medical records 110 consecutive p-NETs who were surgically treated in our center from January 2002 December 2012 reviewed.Sixty-five diagnosed as having tumor G1, 27 had G2, 14...
The death of Sertoli cells (SCs) under condition heat stress (HS) affects spermatogenesis and is associated with impaired function the blood-testis barrier (BTB). fatty acid arachidonic (AA) essential for maintenance cellular function. However, excessive release AA during HS may adversely affect reproductive molecular mechanisms through which modulates BTB in SCs are unclear. In this study, we found that 100 µM damaged testicular morphology accelerated SC apoptosis HS, reducing stability...
Abstract Background To explore the modulatory effects and mechanism of secretory clusterin (sCLU) on cancer stem cell (CSC) properties in hepatocellular carcinoma (HCC). Methods The sCLU repression or overexpression chemoresistance, migration, invasion, tumor growth were detected by MTT, wound healing, transwell assays, xenograft assay, respectively. sphere assay was performed to evaluate self-renewal ability HCC cells. In addition, molecular regulation between AKT/GSK-3β/β-catenin axis...
Autophagy is a tightly regulated process activated in response to metabolic stress and other microenvironmental changes. Astrocyte elevated gene 1 (AEG-1) reportedly induces protective autophagy. Our results indicate that AEG-1 also enhances the susceptibility of malignant glioma cells TGF-β1-triggered epithelial-mesenchymal transition (EMT) through induction TGF-β1 induced autophagy via Smad2/3 phosphorylation cells. Also increased was oncogene cyclin D1 EMT markers, which promoted tumor...
Small heterodimer partner (SHP, NR0B2) is a nuclear orphan receptor without endogenous ligands. Due to its crucial inhibitory role in liver cancer, it of importance identify small molecule agonists SHP. As such, we initiated probe discovery effort compounds capable modulating SHP function. First, performed binding assays using microarrays (SMM) and discovered 5-(diethylsulfamoyl)-3-hydroxynaphthalene-2-carboxylic acid (DSHN) as novel activator DSHN transcriptionally activated Shp mRNA, but...
Aerosol optical depth (AOD) and top-of-atmosphere (TOA) reflectance are two useful sources of satellite data for estimating surface PM2.5 concentrations. Comparison estimates between these approaches remains to be explored. In this study, observations TOA AOD from the Advanced Himawari Imager (AHI) onboard Himawari-8 geostationary in 2016 over Yangtze River Delta (YRD) meteorological used estimate hourly based on four different machine learning algorithms (i.e., random forest, extreme...
The national lockdown policies have drastically disrupted socioeconomic activities during the COVID-19 pandemic in China, which provides a unique opportunity to investigate air quality response such anthropogenic disruptions. And it is meaningful evaluate potential health impacts of changes lockdown, especially for PM2.5 with adverse effects. In this study, by using observations from 1388 monitoring stations nationwide we examine variations between (February and March 2020) same period...