A5072375293- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Complement system in diseases
- IL-33, ST2, and ILC Pathways
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Hepatitis Viruses Studies and Epidemiology
- Circular RNAs in diseases
- Liver Disease and Transplantation
- Sepsis Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cardiac Ischemia and Reperfusion
- Polyamine Metabolism and Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Streptococcal Infections and Treatments
- Acute Kidney Injury Research
- Physiological and biochemical adaptations
- Electrospun Nanofibers in Biomedical Applications
- Child Nutrition and Feeding Issues
- Mast cells and histamine
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanisms of cancer metastasis
- Circadian rhythm and melatonin
Zhejiang Provincial People's Hospital
2021-2024
Hangzhou Medical College
2021-2024
Nanjing Medical University
2016-2021
Jiangsu Province Hospital
2019-2021
Zhejiang Hospital
2021
Abstract Transforming growth factor-β1 (TGF-β1) plays an important role on fibrogenesis in heart disease. MicroRNAs have exhibited as crucial regulators of cardiac homeostasis and remodeling various diseases. MiR-19a-3p/19b-3p expresses with low levels the plasma failure patients. The purpose our study is to determine regulating autophagy-mediated fibrosis human fibroblasts. We elucidate hypothesis clinical samples fibroblasts (HCF) provide valuable basic information. TGF-β1 promotes...
Autophagy is a tightly regulated process activated in response to metabolic stress and other microenvironmental changes. Astrocyte elevated gene 1 (AEG-1) reportedly induces protective autophagy. Our results indicate that AEG-1 also enhances the susceptibility of malignant glioma cells TGF-β1-triggered epithelial-mesenchymal transition (EMT) through induction TGF-β1 induced autophagy via Smad2/3 phosphorylation cells. Also increased was oncogene cyclin D1 EMT markers, which promoted tumor...
Sivelestat, a selective inhibitor of neutrophil elastase (NE), can mitigate sepsis-related acute lung injury. However, the role sivelestat in inhibiting oxidative stress and attenuating kidney injury (AKI) remains unclear. Here, we reported effects against stress-induced AKI by suppressing production indicators.
Exosomal microRNAs (exo-miRNAs or miRs) have demonstrated diagnostic value in various diseases. However, their chronic obstructive pulmonary disease (COPD) has yet to be fully established. The purpose of the present study was screen differentially expressed exo-miRNAs plasma patients with COPD and healthy individuals evaluate potential COPD. Differentially controls were identified using high-throughput sequencing confirmed reverse transcription-quantitative PCR (RT-qPCR). Bioinformatics...
Abstract Background Asthma is characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Airway results from enhanced smooth muscle (ASM) contraction potentially under the control of an epithelium‐derived relaxing factor (EpDRF). However, relatively rare known about EpDRF. We aimed to elucidate role stanniocalcin‐1 (STC1) on AHR ASM contraction. Methods Stanniocalcin‐1 levels in serum asthmatic patients healthy volunteers bronchoalveolar lavage fluid (BALF) ovalbumin...
Community-associated bloodstream infection (CA-BSI) is increasing in many community settings. However, the clinical significance and epidemiology of CA-BSI present hospital admissions China are not well established. In this work, we identified risk factors outpatients presenting with CA-BSI, investigate role procalcitonin (PCT) hypersensitive C-reactive protein (CRP) diagnosing different types pathogen patients acute CA-BSI.A retrospective study enrolling 219 from The Zhejiang People's...
Abstract Astrocyte elevated gene-1 (AEG-1) has been explored as a novel target for human glioma therapy, thus reflecting its potential contribution to gliomagenesis. In the present study, we investigated effect of DYT-40, synthetic 2-styryl-5-nitroimidazole derivative, on cell growth and invasion in glioblastoma (GBM) uncovered underlying mechanisms this molecule. DYT-40 induces intrinsic mitochondrial pathway apoptosis inhibits epithelial-mesenchymal transition (EMT) GBM lines. Furthermore,...
Oxidative stress plays a critical role on the processes of sepsis, and several microRNAs have been identified that may regulate occurrence oxidative stress. However, relation between stress-related microRNA 27a (miR-27a) sepsis is unknown. The present study aimed to determine value circulating miR-27a for diagnosis prognosis sepsis.This retrospective included 23 patients with 25 without treated at emergency intensive care unit (EICU) or our institution January 2019 2020. Levels levels...
Abstract Background Myocardial ischemia–reperfusion injury (MIRI) is the main pathological manifestation of cardiovascular diseases such as myocardial infarction. The potential therapeutic effects bone marrow-derived mesenchymal stem cells (BM-MSCs) and participation regulatory T (Tregs) in MIRI remains to be defined. Methods We used experimental acute that was induced mice by left ascending coronary ischemia, which were subsequently randomized receive immunoglobulin G (IgG) or anti-CD25...
<title>Abstract</title> Traumatic brain injury (TBI) poses a significant threat to human health and well-being, imposing substantial burdens on patients, families, society at large. The mechanisms underlying coagulopathy induced by TBI remain elusive. Given the risk of exacerbated intracranial hemorrhage in early stages TBI, initiation anticoagulant therapy is often deferred. However, an independent factor for venous thromboembolism (VTE), delaying anticoagulation increases VTE incidence...
Bronchial asthma is a heterogeneous disease with complex pathological mechanisms representing different phenotypes, including severe asthma. The airway epithelium major site of changes in due, part, to activation inflammatory and immune response noxious agents. Current imaging procedures are unable accurately measure epithelial remodeling. Damage cells occurs linked specific phenotypes endotypes which provides an opportunity for the identification biomarkers reflecting epithelial, airway,...
With its low morbidity and high mortality rates, thrombotic thrombocytopenic purpura (TTP) has imposed a critical physical economic burden on both society individuals. Thrombocytopenia commonly occurs in severe liver failure, variety of hepatitis viruses are known to induce immune purpura. However, TTP is extremely rare E virus infection. We hereby report case 53-year-old male who present with caused by E, the patients achieved successful recovery after treatment. Therefore, we propose...
Abstract With low morbidity and high mortality, Thrombotic Thrombocytopenic Purpura (TTP) has brought critical physical economic burden to society individual. Thrombocytopenia is very common in severe liver failure, a variety of hepatitis viruses can induce immune thrombocytopenic purpura. However, it extremely rare HEV infection. We hereby report the case 53-year-old man who present with TTP caused by E, patients recovered well after treatment. Thus, we propose considering that for or...
<b>Background:</b> Meteorin-like (ML) increases the eosinophil infiltration into mouse subcutaneous adipose tissue. We hypothesized that ML is involved in pathogenesis of eosinophilic asthma (EA). <b>Methods:</b> examined expression asthmatic patients from a discovery and validation cohorts examine effect on recruitment airways murine model EA human airway epithelial cell(HBE) function vitro. <b>Results:</b> In cohort 105 asthmatics 20 control subjects, serum levels (asthmatics: 613.31±45.16...