A5059501257- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Animal Virus Infections Studies
- Peptidase Inhibition and Analysis
- Vector-Borne Animal Diseases
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Thyroid and Parathyroid Surgery
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Immune cells in cancer
- Acupuncture Treatment Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Complementary and Alternative Medicine Studies
- Viral Infections and Immunology Research
- Respiratory Support and Mechanisms
- Aluminum toxicity and tolerance in plants and animals
- Circadian rhythm and melatonin
- Head and Neck Anomalies
- Pain Management and Placebo Effect
- Renal function and acid-base balance
Weifang People's Hospital
2025
Jiangmen Wuyi Traditional Chinese Medicine Hospital
2025
Nanjing Medical University
2016-2024
Changzhou No.2 People's Hospital
2022-2024
Shanghai First People's Hospital
2021
Nanjing Jiangning Hospital
2018-2020
National Institutes of Health
2003-2019
National Cancer Institute
2010-2019
Nanjing University
2019
Jiangsu Province Hospital
2016-2019
Airway remodelling is an important component of chronic obstructive pulmonary disease (COPD). Neutrophil gelatinase-associated lipocalin (NGAL) from neutrophils may drive COPD epithelial–mesenchymal transition (EMT). NGAL expression was quantified in the lungs patients and bronchoalveolar lavage fluid (BALF) ozone-treated mice. Reticular basement membrane (RBM) thickness E-cadherin α-smooth muscle actin (α-SMA) were determined mice airways. Effects cigarette smoke extract (CSE) inflammatory...
Abstract Although chronic graft-versus-host disease (CGVHD) is the primary nonrelapse complication of allogeneic transplantation, understanding its pathogenesis limited. To identify main operant pathways across spectrum CGVHD, we analyzed gene expression in circulating monocytes, chosen as situ systemic reporter cells. Microarrays identified two interrelated pathways: 1) IFN-inducible genes, and 2) innate receptors for cellular damage. Corroborating these with multiplex RNA quantitation,...
Bronchial epithelial cell damage occurs in patients with bronchial asthma. Ezrin, a membrane-cytoskeleton protein, maintains cellular morphology and intercellular adhesion protects the barrier function of cells.To study role ezrin cells injury correlate its expression asthma severity.Levels were measured exhaled breath condensate (EBC) serum BAL fluid (BALF) from mouse model by ELISA. The regulation IL-13 on protein levels was studied primary cells. Ezrin knockdown using shRNA human 16HBE...
Kidney stones are a chronic metabolic disorder. The cardiometabolic index (CMI) is new and easily accessible measure used to assess status. However, the relationship between CMI incidence of kidney remains unclear. Data from National Health Nutrition Examination Survey (NHANES) was in our cross-sectional study. A weighted multivariable logistic regression analysis conducted stone incidence. Subgroup restricted cubic spline analyses were utilized confirm robustness non-linearity association...
Urinary incontinence, often perceived as embarrassing, perpetuates the stigma that delays treatment and encourages concealment. This significantly diminishes quality of life imposes both financial medical burdens. Although prior research has examined reduction in urinary it persists a widespread issue. Most studies have focused on interviews, primarily addressing urine leakage, with limited understanding factors influencing incontinence their interrelations. More in-depth quantitative are...
Plants cope with aluminum (Al) toxicity by secreting organic acids (OAs) into the apoplastic space, which is driven proton (H+) pumps. Here, we show that mutation of vacuolar H+-translocating adenosine triphosphatase (H+-ATPase) subunit a2 (VHA-a2) and VHA-a3 H+-ATPase enhances Al resistance in Arabidopsis (Arabidopsis thaliana). vha-a2 vha-a3 mutant plants displayed less sensitivity accumulation roots compared to wild-type when grown under excessive Al3+. Interestingly, response Al3+...
Allogeneic blood or marrow transplantation (BMT) is a potentially curative therapy for patients with primary immunodeficiency (PID). Safe and effective reduced-intensity conditioning (RIC) approaches that are associated low toxicity, use alternative donors, afford good immune reconstitution needed to advance the field. Twenty PID patients, ranging in age from 4 58 years, were treated on prospective clinical trial of novel, radiation-free serotherapy-free RIC, T-cell-replete BMT approach...
Abstract Background Asthma is characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Airway results from enhanced smooth muscle (ASM) contraction potentially under the control of an epithelium‐derived relaxing factor (EpDRF). However, relatively rare known about EpDRF. We aimed to elucidate role stanniocalcin‐1 (STC1) on AHR ASM contraction. Methods Stanniocalcin‐1 levels in serum asthmatic patients healthy volunteers bronchoalveolar lavage fluid (BALF) ovalbumin...
Metastatic breast cancer (MBC) response to allogeneic lymphocytes requires donor T-cell engraftment and is limited by graft-versus-host disease (GVHD). In mice, type-II-polarized T cells promote modulate GVHD, whereas type-I-polarized mediate more potent graft-versus-tumor (GVT) effects. This phase I translational study evaluated adoptive transfer of ex vivo costimulated type-I/type-II (T1/T2) with T-cell-depleted (TCD) stem cell transplantation (AlloSCT) for MBC.
Sanfu acupoint herbal patching (SAHP) is a unique traditional Chinese medicine therapy, which has become popular for preventing acute attack of respiratory diseases such as asthma and chronic obstructive pulmonary disease, in many regions mainland China. However, the knowledge about its users lacking, especially characteristics their experience perspectives. To investigate demographics users, conditions use previous SAHP, well users’ perspectives to provide baseline information practice. A...
During a phase 3 clinical trial of rhesus monkey rotavirus-based quadrivalent vaccine in Venezuela, 2207 infants received oral doses ( plaque-forming units/dose) or placebo at ages ∼2, 3, and 4 5 ϫ 10 months; 219 (14%) 1537 stools obtained during 1550 diarrheal episodes postvaccination surveillance were rotavirus-positive by enzyme-linked immunosorbent assay.With the use various VP7 VP4 primers for genotyping purposes, 213 analyzed reverse-transcription polymerase chain reaction.Twenty-nine...
Chronic Graft versus Host Disease (CGVHD) is an autoimmune-like disorder that remains the main cause of nonrelapse morbidity and mortality following allogeneic hematopoietic stem cell transplantation (alloHSCT), yet its pathogenic mechanisms remain poorly understood. To identify systemic cytokine pathways supporting development persistence CGVHD, we performed microarray analysis on sorted monocytes from normal controls (NC) patients with severe cutaneous involvement, including both lichenoid...
Abstract Background Gasless transaxillary endoscopic thyroidectomy (GTET) and via the areola approach (ETA) have emerged as minimally invasive surgical techniques for managing papillary thyroid carcinoma (PTC). This study aimed to assess efficacy of (ET) compared conventional open (COT) in PTC patients. Methods Between 2020 2022, 571 patients underwent unilateral accompanied by ipsilateral central lymph node dissection. cohort comprised 72 who GTET, 105 ETA, 394 COT. The analysis encompassed...
<b>Objective:</b> To study the role of ezrin, a membrane-cytoskeleton protein, in bronchial epithelial cells injury and correlate its expression with asthma severity. <b>Methods:</b> The level ezrin was measured exhaled breath condensate (EBC) serum 61 asthmatics 23 healthy subjects. Ezrin knockdown using shRNA studied IL-13-stimulated 16HBE cells. levels BALF from mouse model were determined by ELISA lung tissue IHC. <b>Results:</b> decreased asthmatic EBC (353.8±37.97 vs159.3 ±10.21 pg/ml,...
<b>Introduction:</b> A variety of inflammatory factors and cells are involved in asthma.Meteorin-like(ML) is a novel cytokine associated with innate acquired immunity may be the pathogenesis. Materials Methods:Serum exhaled breath condensate (EBC) levels ML were measured 47 patients asthma as well 20 normal individuals by ELISA. BALF lung OVA mouse model was also determined. The effect on human 16HBE epithelial <b>Results:</b> Serum increased asthmatic (588±71pg/ml) compared...
Purpose: Practitioner-blinding is often carried out in randomised controlled trials (RCTs) of Chinese herbal medicines (CHMs) yet evaluation blinding infrequently conducted. We aimed to evaluate the feasibility practitioner-blinding within a UK study and identify reasons for practitioner guesses. Methods: conducted patient-blind exploringCHM polycystic ovary syndrome, randomising 40 women standardised CHM or individualised 24 weeks. evaluated at Week 4, 12 End Study (EoS). This questionnaire...
COPD is an inflammatory disease characterized by persistent airflow limitation largely associated with airway remodeling. NGAL a lipocalin family member involved in cell growth and proliferation. We explored the role of on The expression distribution was quantified lungs patients murine model. effect cigarette smoke extract (CSE) as well effects recombinant protein human bronchial epithelial cells (HBEs) smooth muscle cells(HASMCs) also examined. Enhanced found lung neutrophils alveolar...
BACKGROUND: The immune system plays a significant role in cancer prevention and outcome. In high grade gliomas (HGG), severe lymphopenia is associated with shortened survival due to tumor progression. Here we report the first comprehensive study of serial changes lymphocyte subsets HGG following standard radiation (RT) temozolomide (TMZ). METHODS: Adults (KPS > 60, HIV negative) newly diagnosed scheduled receive RT TMZ followed by adjuvant were eligible. Patients enrolled at Johns Hopkins...