A5100385962- Immune cells in cancer
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Histone Deacetylase Inhibitors Research
- Malaria Research and Control
Tianjin Anding Hospital
2024-2025
Tianjin Medical University
2021-2025
Army Medical University
2016-2025
Nankai University
2012-2025
University of Copenhagen
2025
Dalian Medical University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Sun Yat-sen University
2006-2024
Qingdao University
2015-2024
Jilin University
2015-2024
Significance Beyond its canonical functions in processes such as cell-cycle arrest, apoptosis, and senescence, the tumor suppressor p53 has been increasingly implicated metabolism. Here, vitro vivo studies establish a role for gluconeogenesis through previously unidentified mechanism involving ( i ) direct activation of gene encoding NAD-dependent deacetylase sirtuin 6 (SIRT6), ii SIRT6-dependent deacetylation nuclear exclusion forkhead box protein O1 (FoxO1), iii down-regulation...
RNA N6-methyladenosine (m6A) reader protein YTHDF1 has been implicated in cancer; however, its role hepatocellular carcinoma (HCC), especially non-alcoholic steatohepatitis-associated HCC (NASH-HCC), remains unknown. Here, we investigated the functional of NASH-HCC and interplay with tumor immune microenvironment.Hepatocyte-specific Ythdf1-overexpressing mice were subjected to a NASH-HCC-inducing diet. Tumor-infiltrating cells profiled single-cell RNA-sequencing, flow cytometry,...
Forkhead box O (FOXO) transcriptional protein family members, including FOXO1 and FOXO3, are involved in the modulation of autophagy. However, whether there is redundancy between FOXO3 ability to induce autophagy remains unclear. In this study, we showed that induced a transcription-dependent autophagy, was required for process. Overexpression wild-type (WT) or (3A), which harbors alanine mutations at residues Thr32, Ser253 Ser315, but not transcription-inactive (∆DB3A), significantly human...
Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of proteins and organelles. Although autophagy regulation machinery has been widely studied, key epigenetic control still remains unknown. Here we report that methyltransferase EZH2 (enhancer zeste 2 polycomb repressive complex subunit) epigenetically represses several negative regulators MTOR (mechanistic target rapamycin [serine/threonine kinase]) pathway, such as TSC2, RHOA, DEPTOR, FKBP11, RGS16 GPI....
Numerous studies indicate that Sirtuin 1 (SIRT1), a mammalian nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylase (HDAC), plays crucial role in p53-mediated stress responses by deacetylating p53. Nevertheless, the acetylation levels of p53 are dramatically increased upon DNA damage, and it is not well understood how SIRT1–p53 interaction regulated during responses. Here, we identified Set7/9 as unique regulator SIRT1. SIRT1 interacts with both vitro vivo. In response to...
SIRT7 plays a critical role in dissembling and deactivating ATM when DNA damage repair is completed.
SHP2 is an allosteric phosphatase essential for growth factor-mediated Ras activation. Germ-line mutations in cause clinically similar LEOPARD and Noonan syndromes, two of several autosomal-dominant conditions characterized by gain-of-function the pathway. Interestingly, syndrome mutants are constitutively active, whereas exhibit reduced activity. How do catalytically impaired engender phenotypes? Our study reveals that weaken intramolecular interaction between N-SH2 domains, leading to a...
Suppressor of variegation 3–9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes 3 lysine 9 trimethylation and is involved in heterochromatin organization genome stability. However, the mechanism for regulation enzymatic activity SUV39H1 cancer cells not yet well known. In this study, we identified SET domain-containing protein 7 (SET7/9), as unique regulator activity. response to treatment with adriamycin, DNA damage inducer, SET7/9 interacted vivo, GST pull-down assay confirmed...
In mammals it is unclear if UHRF1-mediated DNA maintenance methylation by DNMT1 strictly dependent on histone H3K9 methylation. Here we have generated an Uhrf1 knockin (KI) mouse model that specifically abolishes the H3K9me2/3-binding activity of Uhrf1. The homozygous KI mice are viable and fertile, exhibit ∼10% reduction in various tissues. reduced occurs globally genome does not restrict only to H3K9me2/3 enriched repetitive sequences. vitro UHRF1 binds with higher affinity reconstituted...
Increased glycolysis facilitates reciprocal activation between myeloid cells and endothelial in pathological retinal angiogenesis.
Background and Aims: NASH-HCC is inherently resistant to immune checkpoint blockade, but its tumor microenvironment largely unknown. Approach Results: We applied the imaging mass cytometry construct a spatially resolved single-cell atlas from formalin-fixed paraffin-embedded tissue sections patients with NASH-HCC, virus-HCC (HBV-HCC HCV-HCC), healthy donors. Based on 35 biomarkers, over 750,000 individual cells were categorized into 13 distinct cell types, together expression of key...
Self-nonself discrimination is vital for the immune system to mount responses against pathogens while maintaining tolerance toward host and innocuous commensals during homeostasis. Here, we investigated how indiscriminate DNA sensors, such as cyclic GMP-AMP synthase (cGAS), make this self-nonself distinction. Screening of a small-molecule library revealed that spermine, well-known condenser associated with viral DNA, markedly elevates cGAS activation. Mechanistically, spermine condenses...
To determine the effect of higher progesterone (P) level on endometrial receptivity.This was a prospective analysis conducted in Reproductive Medical Center Peking University Third Hospital. All patients received IVF treatment and canceled embryo transfer same cycle were divided into group 1 (normal P; 7 patients) 2 (elevated 12 patients). Endometrial biopsies performed 6 days after oocyte retrieval. The global miRNA mRNA gene expressions investigated with V4.0 probe 22 K Human Genome Array....
Significance The G9a histone methyltransferase primarily regulates the expression of genes associated with cancer development in cells, but it has also been implicated mediating DNA damage response. Here, we confirmed a role for repair following double-strand breaks. is recruited to chromatin as result casein kinase 2-mediated phosphorylation, where directly interacts replication protein A (RPA). binding RPA modulates and Rad51 foci formation permits efficient homologous recombination. This...
Silk fibroin/cartilage extracellular matrix scaffolds with sequential delivery of TGF-beta3 for chondrogenic differentiation adipose-derived stem cells Qiang Yang,1,* Bin-Hong Teng,2,* Li-Na Wang,3 Kun Li,2 Chen Xu,2 Xin-Long Ma,1 Yang Zhang,1 De-Ling Kong,3 Lian-Yong Yan-Hong Zhao2 1Department Spine Surgery, Tianjin Hospital, , People's Republic China; 2School and Hospital Stomatology, Medical University,Tianjin, 3The Key Laboratory Bioactive Materials, Ministry Education, College Life...
Linker histone H1 is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair unclear. Here, we report that linker H1.2 an essential ataxia telangiectasia mutated (ATM) activation. We show protects from aberrant ATM activation through direct interaction with HEAT repeat domain inhibition MRE11-RAD50-NBS1 (MRN) complex-dependent recruitment. Upon damage, undergoes rapid PARP1-dependent dissociation poly-ADP-ribosylation (PARylation) C...
Abstract This study explored the strength and mechanisms of intention‐use link in Technology Acceptance Model (TAM), based on data from a sample 198 in‐service college‐level foreign‐language teachers China. Its sequential explanatory research design involved, firstly, quantitative approach to examine structural relations among TAM's variables, using path analysis survey data; secondly, qualitative interviews with purposive sub‐sample 16 same teachers, aimed at identifying potential...
Abstract Refractory periapical periodontitis, which is a persistent infection after root canal treatment, still has no effective treatment. Its most common pathogen Enterococcus faecalis . Here, the precursor of phytosteroids, dioscin, introduced to fight against inflammation induced by The findings suggest that dioscin inhibits nuclear transport NF‐κB and expression reactive oxygen species (ROS) lipoteichoic acid from decrease in mRNA protein levels NLRP3, Caspase‐1, IL‐1β observed treated...