A5032790270- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
- Proteoglycans and glycosaminoglycans research
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Advanced Computing and Algorithms
- Immunotherapy and Immune Responses
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
Second Affiliated Hospital of Zhejiang University
2023-2025
Peking University
2020-2023
King University
2021
Tianjin Stomatological Hospital
2017-2020
Tianjin Medical University
2017-2020
Silk fibroin/cartilage extracellular matrix scaffolds with sequential delivery of TGF-beta3 for chondrogenic differentiation adipose-derived stem cells Qiang Yang,1,* Bin-Hong Teng,2,* Li-Na Wang,3 Kun Li,2 Chen Xu,2 Xin-Long Ma,1 Yang Zhang,1 De-Ling Kong,3 Lian-Yong Yan-Hong Zhao2 1Department Spine Surgery, Tianjin Hospital, , People's Republic China; 2School and Hospital Stomatology, Medical University,Tianjin, 3The Key Laboratory Bioactive Materials, Ministry Education, College Life...
Immune checkpoint blockades (ICBs) are a promising treatment for cancers such as melanoma by blocking important inhibitory pathways that enable tumor cells to evade immune attack. Programmed death ligand 1 monoclonal antibodies (aPDL1s) can be used an ICB significantly enhance the effectiveness of immunotherapy PD-1/PD-L1 pathway. However, aPDL1s may limited low selectivity in vivo and immunosuppressed microenvironment including hypoxia.To overcome limitations, we develop multifunctional...
Abstract The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction articular (NAC) after injury is challenging due its complex structure, low cellular content, less vascularity. Inspired by concrete rebar a named “biological reinforced concrete” fabricated, collagen fiber orientation transitioning from parallel perpendicular, replicating ECM construct NAC. 3D‐printed ultrafine...
Objective To explore the effect of kartogenin (KGN) on proliferation and chondrogenic differentiation human umbilical cord mesenchymal stem cells (hUCMSC) in vitro , synergistic effects KGN transforming growth factor (TGF)‐β3 hUCMSC. Methods Human were isolated cultured. Then properties identified by flow cytometry analysis. HUCMSC divided into four groups: control group, TGF‐β3 TK group (with added medium simultaneously). Cells all groups induced for 21 days using suspension ball culture...
A tripeptide-based macroporous hydrogel simultaneously promoted osteogenesis and angiogenesis, which is significant for 3D cultures stem cell-based tissue engineering.
Using injectable hydrogels loaded with mesenchymal stem cells (MSCs) to repair chondral defects is a new trend of cartilage tissue engineering in recent years. In this study, hyaluronic acid (HA) containing the system sustained-release Kartogenin (KGN) and modified by RGD HAV peptides were used facilitate defect knee joint rabbits. Different groups implants injected into osteochondral defects, samples taken 4 weeks after operation. Through qualitative quantitative analysis Micro-CT, it can...
This study aimed to optimize the preparation of carboxymethyl chitosan/sodium alginate (CMCS/OSA) compound hydrogels. also investigate applicability hydrogels in cartilage tissue engi-neering.
This study aimed to prepare oriented scaffolds derived from a cartilage extracellular matrix (CECM) and investigate their physicochemical property compatibility with adipose-derived stem cells (ADSCs).A fresh porcine articular was cut into pieces. Cartilage nanofibers diameters of 50-500 nm were collected through homogenization centrifugation. These then decellularized by using Triton X-100 produce 6% CECM. The the nanoscale CECM fabricated unidirectional solidification lyophilization....
This study aims to prepare oriented scaffolds derived from a cartilage extracellular matrix (CECM) and silk fibroin (SF) use investigate their physicochemical property in tissue engineering.Oriented SF-CECM were prepared 6% mixed slurry (CECM：SF=1：1) through modified temperature gradient-guided thermal-induced phase separation, followed by freeze drying. The evaluated scanning electron microscopy (SEM) histological staining analyses determination of porosity, water absorption, compressive...
Hydrogel scaffolds are widely used in cartilage tissue engineering as a natural stem cell niche. In particular, hydrogels based on multiple biological signals can guide behaviors of mesenchymal cells (MSCs) during neo-chondrogenesis. the first phase this study, we showed that functionalized with grafted arginine-glycine-aspartate (RGD) peptides and lower degree crosslinking promote proliferation human (hMSCs) upregulate expression receptor proteins. Moreover, RGD histidine-alanine-valine...