A5016194015- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Osteoarthritis Treatment and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Amino Acid Enzymes and Metabolism
- Folate and B Vitamins Research
- Advanced Computing and Algorithms
- Histone Deacetylase Inhibitors Research
- Silk-based biomaterials and applications
- PI3K/AKT/mTOR signaling in cancer
- RNA Research and Splicing
- Periodontal Regeneration and Treatments
- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Proteoglycans and glycosaminoglycans research
- Graphene and Nanomaterials Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Hydrogels: synthesis, properties, applications
- Birth, Development, and Health
- Lipid metabolism and biosynthesis
- Bone Tissue Engineering Materials
Yan'an University
2023-2024
Binzhou University
2024
Binzhou Medical University
2024
Peking University
2017-2023
Huazhong Agricultural University
2023
American Pharmacists Association
2017
A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across blood-brain barrier, and transporting mechanism to glioma cells Chang Liu,1,* Xiao-Na Gui-Ling Wang,1 Yu Hei,1 Shuai Meng,1 Ling-Fei Yang,1 Lan Yuan,2 Ying Xie1 1Beijing Key Laboratory of Molecular Pharmaceutics New Drug Delivery Systems, Department Pharmaceutics, School Pharmaceutical Sciences, 2Medical Healthy Analysis Center, Peking University, Beijing, People’s Republic...
Immune checkpoint blockades (ICBs) are a promising treatment for cancers such as melanoma by blocking important inhibitory pathways that enable tumor cells to evade immune attack. Programmed death ligand 1 monoclonal antibodies (aPDL1s) can be used an ICB significantly enhance the effectiveness of immunotherapy PD-1/PD-L1 pathway. However, aPDL1s may limited low selectivity in vivo and immunosuppressed microenvironment including hypoxia.To overcome limitations, we develop multifunctional...
Exosomes, as a class of small extracellular vesicles closely related to the biological behavior various types tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding diagnosis, stability their membrane structure wide distribution body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor future. For treatment, exosomes, “golden communicators” between cells, can be designed...
Abstract: In vivo evaluation of drug delivery vectors is essential for clinical translation. BALB/c nude mice bearing human breast cancer tumors, we investigated the biocompatibility, pharmacokinetics, and pharmacodynamics doxorubicin (DOX)-loaded novel cell-penetrating peptide (CPP)-modified pH-sensitive liposomes (CPPL) (referred to as CPPL(DOX)) with an optimal CPP density 4%. CPPL, a polyethylene glycol (PEG) derivative formed by conjugating PEG stearate via acid-degradable hydrazone...
Abstract The immunosuppressive tumor microenvironment (TME) can significantly limit the immunotherapeutic effects of PD‐L1 antibody (aPDL1) by inhibiting infiltration CD8 + cytotoxic T cells (CTLs) into tissues. However, how to reprogram TME and promote CTLs remains a huge challenge for aPDL1 achieve maximum benefits. Herein, authors design multifunctional immunoliposome that encapsulates adrenergic receptor blocker carvedilol (CAR) connects “don't eat me” signal (aCD47) in series via...
Neurovascularized bone regeneration remains an enormous challenge in the clinic.
A tripeptide-based macroporous hydrogel simultaneously promoted osteogenesis and angiogenesis, which is significant for 3D cultures stem cell-based tissue engineering.
As a dietary strategy, methionine restriction has been reported to promote longevity and regulate metabolic disorders. However, the role possible regulatory mechanisms underlying in neurodegenerative diseases such as Alzheimer's disease (AD), remain unexplored. This study utilized data from BXD recombinant inbred (RI) mice establish correlation between AD phenotype level. Gene enrichment analysis indicated that genes associated with concentration of midbrain are involved dopaminergic...
Hydrogel scaffolds are widely used in cartilage tissue engineering as a natural stem cell niche. In particular, hydrogels based on multiple biological signals can guide behaviors of mesenchymal cells (MSCs) during neo-chondrogenesis. the first phase this study, we showed that functionalized with grafted arginine-glycine-aspartate (RGD) peptides and lower degree crosslinking promote proliferation human (hMSCs) upregulate expression receptor proteins. Moreover, RGD histidine-alanine-valine...