A5032365887- Ginseng Biological Effects and Applications
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Extracellular vesicles in disease
- RNA regulation and disease
- Phytoestrogen effects and research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Viral Infections and Immunology Research
- Tannin, Tannase and Anticancer Activities
- Cell death mechanisms and regulation
Yan'an University
2022-2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Zhejiang Chinese Medical University
2022
Pancreatic cancer is a highly aggressive malignant tumor, that becoming increasingly common in recent years. Despite advances intensive treatment modalities including surgery, radiotherapy, biological therapy, and targeted the overall survival rate has not significantly improved patients with pancreatic cancer. This may be attributed to insidious onset, unknown pathophysiology, poor prognosis of disease. It therefore essential identify develop more effective safer treatments for Tumor...
Exosomes, as a class of small extracellular vesicles closely related to the biological behavior various types tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding diagnosis, stability their membrane structure wide distribution body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor future. For treatment, exosomes, “golden communicators” between cells, can be designed...
Abstract It is well established that sevoflurane exposure leads to widespread neuronal cell death in the developing brain. Adenosine deaminase acting on RNA-1 (ADAR1) dependent adenosine-to-inosine (A-to-I) RNA editing dynamically regulated throughout brain development. The current investigation designed interrogate contributed role of ADAR1 developmental neurotoxicity. Herein, we provide evidence show priming triggers pyroptosis, apoptosis and necroptosis (PANoptosis), elicits release...
Saikosaponin D (SSD), a saponin derivative, is extracted from Bupleurum falcatum. It exhibits an inhibitory effect on number of tumor cells and relatively safe when used at therapeutic doses. However, its effects glioblastoma multiforme (GBM) have not been fully explored. This study aimed investigating the cytotoxic SSD in GBM cell lines. induces apoptosis autophagy by activating endoplasmic reticulum (ER) stress cells. proliferation activity morphology were observed using Cell Counting...
Abstract Background: Glioblastoma multiforme (GBM) is a primary aggressive brain tumor with high morbidity and mortality. Temozolomide (TMZ) has been applied to the treatment of GBM for over decade, but TMZ resistance major obstacle preventing recurrence after surgery. In this study, effect Saikosaponin D (SSD) on increasing sensitivity was investigated by activating endoplasmic reticulum (ER) stresspathway. Methods: Three cell lines different sensitivities were selected, including rat RG-2...
This study aims to investigate the effect and mechanism of saikosaponin D on proliferation, apoptosis, autophagy pancreatic cancer Panc-1 cells. The cell counting kit(CCK-8) was used examine effects 7, 10, 13, 16, 19, 22, 25, 28 μmol·L~(-1) proliferation Three groups including control(0 μmol·L~(-1)), low-concentration(10 μmol·L~(-1)) D, high-concentration(16 were designed. colony formation assay employed measure rate cells treated with stained hematoxylin-eosin(HE), changes morphology...