A5100347512- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Methane Hydrates and Related Phenomena
- Ginseng Biological Effects and Applications
- Chemical Synthesis and Analysis
- Dendrimers and Hyperbranched Polymers
- Porphyrin and Phthalocyanine Chemistry
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Antimicrobial Peptides and Activities
- Phytochemical Studies and Bioactivities
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Click Chemistry and Applications
- Kruppel-like factors research
- Lipid Membrane Structure and Behavior
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Magnolia and Illicium research
- Heat shock proteins research
- Plant Molecular Biology Research
- Nanopore and Nanochannel Transport Studies
- Ginger and Zingiberaceae research
Xuzhou Medical College
2023-2024
Yan'an University
2024
Pacific Northwest National Laboratory
2018-2023
Tengzhou Central People's Hospital
2015-2023
Hefei National Center for Physical Sciences at Nanoscale
2023
University of Science and Technology of China
2023
Jiangsu University
2021
Integrated Chinese Medicine (China)
2021
Qingdao University
2019
Qingdao Women and Children's Hospital
2019
Abstract Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe disorders, there currently no Food Drug Administration–approved drug therapies. Melatonin is a well‐known anti‐inflammatory molecule, which has proven to be effective in ALI induced by many conditions. Emerging studies suggest that the NLRP3 inflammasome plays critical role during ALI. How melatonin directly blocks activation of remains unclear. In this study, using an LPS‐induced mouse...
Despite recent advances in the assembly of organic nanotubes, conferral sequence-defined engineering and dynamic response characteristics to tubules remains a challenge. Here we report new family highly designable nanotubes assembled from peptoids through unique "rolling-up closure nanosheet" mechanism. During process, amorphous spherical particles amphiphilic peptoid oligomers crystallize form well-defined nanosheets before folding single-walled nanotubes. These undergo pH-triggered,...
Polyethylenimine (PEI) is one of the most promising polymeric gene vectors, however its applications are limited by serious cytotoxicity and moderate transfection efficacy. Fluorination an efficient strategy to improve efficacy cationic polymers while reducing their cytotoxicity. Here we grafted different fluoroalkyl chains PEI via oxirane anhydride reactions. The fluorinated PEIs show superior on both 2D 3D cell cultures unmodified PEI. These allow at relatively low nitrogen phosphorus...
Substantial progress has been made in applying nanotubes biomedical applications such as bioimaging and drug delivery due to their unique architecture, characterized by very large internal surface areas high aspect ratios. However, the of organic nanotubes, especially for those assembled from sequence-defined molecules, are uncommon. In this paper, synthesis two new peptoid (PepTs1 PepTs2) is reported using ligand-tagged peptoids building blocks. These highly robust sharing a similar...
Exosomes, as a class of small extracellular vesicles closely related to the biological behavior various types tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding diagnosis, stability their membrane structure wide distribution body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor future. For treatment, exosomes, “golden communicators” between cells, can be designed...
Abstract Polymers are widely used as non-viral carriers for siRNA delivery, but concern has also arisen in their limited efficacy and inherent toxicity. Whilst many of previous efforts have been documented towards improving the performance polymers via chemical modifications, structure-activity relationships (SAR) these ligand-modified not well understood. To address this issue, we systemically prepared a library surface-engineered dendrimers (>300) screening pool to discover efficient...
Near-infrared (NIR) laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy. However, insufficient tumor killing due to nonuniform heat or cytotoxic singlet oxygen ( 1 O 2 ) distribution over tumors from results in recurrence and inferior outcomes. To achieve high efficacy, one of solutions is employ combinational treatment with other modalities, especially chemotherapeutic agents. In this paper, a simple effective multimodal therapeutic system...
Inspired by the formation of hierarchically structured natural biominerals (e.g., bone and tooth), various sequence-defined polymers have been synthesized exploited for design synthesis functional hybrid materials. Here, we a series organic-inorganic peptoids using polyhedral oligomeric silsesquioxane (POSS) nanoclusters as side chains at variety backbone locations. We further demonstrated use these building blocks to assemble new class programmable two-dimensional (2D) nanocrystals. They...
Rechargeable Li-Cl2 batteries are recognized as promising candidates for energy storage due to their ultrahigh densities and superior safety features. However, suffer from a short cycle life low Coulombic efficiency (CE) at high specific cycling capacity sluggish insufficient Cl2 supply during the redox reaction. To achieve with discharge CE, herein, we propose design an imine-functionalized porous organic nanocage (POC) enrich molecules. Based on density functional theory (DFT)...
Abstract The design and synthesis of biocompatible nanomaterials as cargoes for the intracellular delivery therapeutic proteins or genes have attracted intense attention because their potential use in therapeutics. Despite advances this area, very few can be efficiently delivered to cytosol. To address these challenges, crystalline nanoflower‐like particles are designed synthesized from fluorinated sequence‐defined peptoids; crystallinity fluorination enable highly efficient cytosolic with...
The delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene into cancer cells is a promising strategy for treatment. However, the low transfection efficacy and/or toxicity vectors severely hamper translation TRAIL therapy clinics. In this article, we employed our recently developed fluorinated dendrimer as vector to deliver plasmid encoding (pTRAIL) treatment, which holds advantages both excellent and toxicity. Fluorinated poly(amidoamine) (G4-F735) represented much...
Objective: This study aimed to investigate the role of fibroblast growth factor-5 (FGF5) in osteosarcoma (OS) and explore potential mechanisms. Methods: OS gene expression data was downloaded from Gene Expression Omnibus (GEO; GSE12865) analyzed by R software. tissues cell lines were collected. The level FGF5 tumor detected using qRT-PCR. Knockout performed CRISPR/Cas9 system. effects knockout on proliferation determined through counting kit-8 assay xenograft nude mice, respectively....
During the past few decades, a variety of two-dimensional (2D) nanomaterials have been developed through molecular self-assembly. Among them, those assembled from sequence-defined polymers received particular attention because they enable programmable display functional groups, including fluorescent dyes, on their surfaces for applications. On other hand, due to fluorescence self-quenching, synthesis 2D exhibiting high quantum yields is significant challenge. Herein, we design and synthesize...
Key genes related to plant type traits have played very important roles in the "green revolution" by increasing lodging resistance and elevating harvest indices of crop cultivars. Although there been numerous achievements development dwarfism Brassica napus breeding, exploring new materials conferring oilseed rape with efficient types that provide higher yields is still significance as well elucidating mechanisms underlying development. Here, we report a dwarf architecture down-curved leaf...
Free-standing two-dimensional (2D) organic nanomaterials are highly attractive for biological applications because of their unique structural properties and high biocompatibility. Herein, we designed synthesized a new class bright photostable membrane-mimetic 2D nanosheets from sequence-defined peptoids. These exhibited quantum yield photostability as result the precise placement ordering dansyl dye molecules within crystalline nanosheets. We further showed use these biocompatible...
Background Cancer cells with overexpression of heat shock protein 27 (HSP27) are resistant to chemotherapeutic drug doxorubicin (Dox). Paclitaxel (Pacl) was reported suppress HSP27 expression in ovarian and uterine cancer cells. The purposes this study were investigate whether Pacl inhibits the breast cells, can sensitize Dox, define a more effective schedule for combination Dox Pacl. Methods high-expressing human cell lines, MCF-7 MDA-MB-435, low-expressing line, MDA-MB-231, used study....
Objectives Previous studies have found that Panax quinquefolius saponins (PQS) combined with dual antiplatelet therapy (DAPT) of aspirin and clopidogrel enhances antithrombotic effects while reducing gastric mucosal injury induced by DAPT. We investigated the drug (PQS+DAPT) through COX/PG pathways. Methods Acute myocardial infarction (AMI) was in Wistar rats ligation left anterior descending (LAD) coronary artery, animals were randomly divided into Model, DAPT, PQS+DAPT groups. Rats sham...
ConspectusThe grand scale, ultimate efficiency, and sustainability of natural photosynthesis have inspired generations researchers in biomimetic light energy utilization. As an essential ubiquitous component all photosynthetic machinery, lipids their assemblies long been recognized as powerful molecular scaffolds building artificial systems. Model lipid bilayers, such black membranes liposomes (vesicles), extensively used to host well synthetic photo- redox-active species, thereby enabling...