Exosomes, as a class of small extracellular vesicles closely related to the biological behavior various types tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding diagnosis, stability their membrane structure wide distribution body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor future. For treatment, exosomes, “golden communicators” between cells, can be designed...

Tiltrotor aircraft have three flight modes: helicopter mode, airplane and transition mode. A tiltrotor has characteristics of highly nonlinear, time-varying dynamics inertial/control couplings in its It can transit from the mode to by tilting nacelles, an effective controller is crucial accomplish missions. Longitudinal dynamic are described a nonlinear Lagrange-form model, which takes into account aerodynamic interferences. Reference commands for airspeed velocity attitude calculated...

The center of gravity variations have a direct impact on the dynamic and quality characteristics aircraft, which makes control aircraft more difficult after shifting. In order to solve this problem, an model that can simulate both instantaneous gradual shift has been built as research object. Based model, adaptive nonsingular fast terminal sliding mode controller is proposed Fast combined with method in controller, improved attractor eliminate chattering phenomenon nonlinear law compensate...

This study provides a promising approach to improve angiogenesis and osteogenesis in an ischemic environment.

It is a common treatment strategy in the clinic to transplant vascularized bone flap for large defect. But it difficult peripheral blood vessels grow into central region of construct. In this study, we fabricated from three-dimensional (3D)-printed biodegradable poly(lactide-co-glycolide) (PLGA)/β-tri-calcium phosphate (β-TCP) scaffold using combination an arteriovenous (AV) bundle and recombinant human morphogenetic protein-2 (rhBMP-2). A degradable porous PLGA/β-TCP was prepared by...

Large scale variations in the mass or center of gravity (C.G.) pose serious problems for control aircraft situations as heavy load airdrop on cargo aircraft, airliners which employ active C.G. technology, with structural damages during flight. To solve problem attitude such a general model is established and disturbance rejection controller proposed. The proposed comprises 6-DOF dynamics variation model, can handle various reflect dynamic couplings introduced by variations. For based...

Active center of gravity (C.G.) control is a key technology vehicle management system, which has been extensively used in various types aircraft. With active C.G. aircraft may deviate from its known dynamics due to the offset, thus bringing new problems existing flight system. A design approach attitude system with variations proposed this paper. First all, 6-DoF model built. Taking effects shift into consideration, equations motion expressed body-fixed reference frame are derived using...

The development of controlled drug delivery systems for bone regeneration, especially microspheres, has become a research hotspot in recent years. Chitosan and its derivative O-carboxymethyl chitosan have been considered to be an effective way due their nontoxicity biodegradability. Currently, most the studies researched on synthesizing characterizing chitosan. However, few focused differences between microspheres directly. In this study, were developed by water-in-oil emulsification...

Recently, point cloud data has attracted increasing attention in various machine vision tasks like classification and detection. However, directly transmitting the raw for such will bring a huge bit-rate cost. In this work, we propose new compression framework called PCHM-Net both human vision. Our proposed adopts two-branch structure with shared octree-based module. To better compress save tasks, use selection module to select sparse set of points before octree construction, which allows us...

In the process of solving Traveling Salesman Problem (TSP), both Ant Colony Optimization and simulated annealing exhibit different limitations depending on dataset. This article aims to address these by improving combining two algorithms using clustering method. The problems tackled include Optimization's susceptibility stagnation, slow convergence, excessive computations, local optima, as well annealing's convergence limited search capability. By conducting tests various TSPLIB datasets,...

In this paper, a control method combining Active Disturbance Rejection Control (ADRC) and optimal is discussed for large aircraft landing attitude with disturbances, such as turbulence, gusts modeling errors. On the basis of extended state observer (ESO) inherited from ADRC, our design exploits Linear Quadratic Regular (LQR) replacing original Proportional-Derivation (PD) gains. This technique can effectively solve adjustment problems former channel parameters in guarantee unknown...

Owing to the complexity of aircraft structural damage, directly measuring pattern and severity damage using onboard sensors is difficult. This paper proposes a linear parameter-varying (LPV) model–based online estimation indirect adaptive control scheme for with severe damage. Specifically, unmeasurable parameters are designed as gain scheduling coefficients (GSCs) LPV model. By employing proposed model, computational load significantly reduced compared that typical existing methods....

Excitation system is one of the key elements affecting dynamic performance electric power systems. Therefore, accurate models are great importance in simulation and investigation transient phenomena. In this paper, a nonlinear identification method for excitation (EXS) Mianhuatan plant China presented. Two different methods, i.e., genetic algorithm prediction error (PEM) used compared. algorithm, block-diagram EXS suggested at first. investigated system, measurement was performed no-load...

Aircraft center of gravity control is an important technology to gain potential performance benefits. In-flight usually based on a fuel transfer system which enables be transferred among fuselage tanks and then adjust aircraft gravity. The aim this article systematically investigate the influences partial pump failures CG for high-speed aircraft. As basis, modeling process varying with put forward sliding model law presented in detail. Then detailed simulation analysis possible effects...

Purpose Boundary layer ingestion (BLI) is one of the probable noteworthy features distributed propulsion configuration (DPC). Because BLI, strong coupling effects are generated between aerodynamics and system aircraft, leading to specific lift drag aerodynamic characteristics. This paper aims propose a model-based comprehensive analysis method investigate this unique aerodynamic. Design/methodology/approach To aerodynamics, proposed. uses detailed mathematical model provide essential...

Focusing on the abrupt parameter variation of aircraft dynamic characteristics brought by wing damage, an observer based multivariable reference adaptive control(O-MRAC) method is presented. Firstly, The Multivariable Model Reference Adaptive Control (M-MRAC) studied to compensate variations in state matrix, control matrix and constant uncertainty. In order improve tracking speed precision, Compensation Observer Unit(COU) Extended State Observer(ESO) introduced combined with M-MRAC. Finally...

Considering the strong uncertainties of aerodynamic parameters and atmospheric environment large dynamic variation during Reusable Launch Vehicle (RLV) reentry process, this paper introduces an attitude controller design method which combines Linear Quadratic Regulator (LQR) with Fuzzy Gain-Scheduling (FGS). The whole operating envelope is divided into several points firstly. And then, control state deviation based LQR controllers are designed for respectively. Thereafter FGS obtained by use...

Focusing on the abrupt parameter variation of aircraft dynamic characteristics brought by wing damage, a multivariable adaptive reconfigurable control method has been studied. First nonlinear 6DOF model structural damaged is presented. The linearization process and coupling between longitudinal lateral dynamics are studied, denoted as linear form with uncertain variations. And then Multivariable Model Reference Adaptive Control (M-MRAC) introduced to compensate variations in state matrix,...