A5101968127- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Cholesterol and Lipid Metabolism
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Calpain Protease Function and Regulation
- Photoacoustic and Ultrasonic Imaging
- Angiogenesis and VEGF in Cancer
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Lipid metabolism and biosynthesis
- Natural Compound Pharmacology Studies
- Endometrial and Cervical Cancer Treatments
Shanxi Medical University
2023-2025
Shanxi Provincial Cancer Hospital
2024
Beijing National Laboratory for Molecular Sciences
2022
Chinese Academy of Sciences
2022
University of Tübingen
2019-2021
Shengli Oilfield Central Hospital
2021
Tianjin Third Central Hospital
2020
Tianjin Medical University
2020
University of Kansas Medical Center
2020
Cancer Hospital of Chinese Academy of Medical Sciences
2018
Tumor blood vessels are tortuous and dilated, contributing to the aberrant tumor microenvironment. CD93 is a newly reported transmembrane receptor, mainly expressed in endothelial cells, that has demonstrated prognostic value some cancer types. However, role of vasculature colorectal (CRC) tissues its significance remain unknown. It therefore necessary explore effect patients with CRC. We detected expression human CRC using immunohistochemistry. then examined correlation between...
Gambogic acid (GA) has been approved by the Chinese Food and Drug Administration for treatment of lung cancer in clinical trials. However, whether GA chemosensitizing properties when combined with other chemotherapy agents is not known. Here we investigated effects adriamycin (ADM), a common agent, regard to their activities possible mechanisms against vitro vivo. Cell viability results showed that sequential GA-ADM was synergistic, while reverse sequence simultaneous treatments were...
Abstract: In vivo evaluation of drug delivery vectors is essential for clinical translation. BALB/c nude mice bearing human breast cancer tumors, we investigated the biocompatibility, pharmacokinetics, and pharmacodynamics doxorubicin (DOX)-loaded novel cell-penetrating peptide (CPP)-modified pH-sensitive liposomes (CPPL) (referred to as CPPL(DOX)) with an optimal CPP density 4%. CPPL, a polyethylene glycol (PEG) derivative formed by conjugating PEG stearate via acid-degradable hydrazone...
Oxidative stress and hypoxia are two opposite microenvironments involved in HCC metastasis. Thioredoxin (TXN) hypoxia-inducible factor 2α (HIF-2α) typical proteins these different microenvironments, respectively. How factors interact to influence the fate on tumor cells remains unknown. Hypoxia facilitated withstood oxidative eventually promoted metastasis, which TXN HIF-2α were mostly involved. Upregulation of TXN/HIF-2α correlated with poor prognosis metastasis both vitro vivo....
Under inflammatory conditions or during tumor progression macrophages acquire distinct phenotypes, with factors of the microenvironment such as hypoxia and transforming growth factor β (TGFβ) shaping their functional plasticity. TGFβ is among causing alternative macrophage activation, which contributes to tissue regeneration thus, resolution inflammation but may also provoke progression. However, signal crosstalk between ill defined.Exposing human primary elicited a rapid SMAD2/SMAD3...
Ultrasound-targeted microbubble destruction (UTMD) is a novel adjuvant tumor therapeutic method by enhancing exogenous gene transfection to target tissues. This study aims investigate the role of microRNA-492 (miR-492) in non-small cell lung cancer (NSCLC) and further analyze effects UTMD-mediated miR-492 inhibitor on tumorigenesis.The expression was detected qRT-PCR. Co-transfection microbubbles with Lipofectamine 3000 performed achieve inhibition NSCLC cells. CCK-8 Transwell assay were...
Abstract Purpose This study aims to investigate the expression patterns and clinical significance of miR-140-3p homeobox A9 (HOXA9) in colorectal cancer (CRC) selected by bioinformatic study, while elucidating their potential interplay. Methods The microRNA profiles paired matched normal tissues were retrieved from Gene Expression Omnibus Database. Differentially expressed microRNAs candidates filtered subjected further analysis. Clinicopathological data, along with paraffin-embedded samples...
e15500 Background: Colorectal signet ring cell carcinoma (CRC-SRC) is a malignant tumour characterized by its aggressive nature and unfavourable prognosis. In spite of the fact that numerous studies have examined molecular profile therapeutic targets CRC-SRC, prognostic biomarkers for this malignancy continue to be unknown. Methods: We conducted comprehensive analysis multi-omics in 35 cases CRC-SRC 10 colorectal adenocarcinomas (CRC-AC). This involved various techniques, including...
Abstract Purpose: Cell-free circulating tumor DNA (ctDNA) in plasma enables rapid and repeat testing of actionable mutations. Next-generation sequencing (NGS) is an attractive platform for multiplex capabilities compared to traditional methods such as PCR. The purpose this study evaluate the value NGS-based ctDNA assay identify genomic alteration profile real-world Chinese non-small cell lung (NSCLC) patients. Methods : In total, 294 patients with pathological diagnosis Phase III-IV NSCLC...
Background: Compared to colorectal adenocarcinoma (CRC-AC), signet-ring cell carcinoma (CRC-SRC) has a worse prognosis, more aggressive behavior, and no effective treatment. The therapeutic development of CRC-SRC been hindered due lack molecular knowledge. Methods: We performed the 551 cancer-related gene panel, transcriptome profile, multiple immunohistochemistry tests on FFPE specimens primary signet ring carcinomas (CRC-SRC, n=35) adenocarcinomas (CRC-AC, n=10). Findings: group had lower...
Background: FUN14 domain-containing 1 (FUNDC1), as a novel member of mitochondria-associated endoplasmic reticulum (ER) membranes. However, the expression profile and functional roles FUNDC1 remain largely unclear in human cancer biology, including breast (BC). Methods: Immunohistochemistry western blot analysis were used to determine BMI1 polycomb ring finger oncogene (BMI1). CCK8, cell counting transwell assays analyze proliferation, migration invasion, respectively. Luciferase reporter...
To study C-X-C motif chemokine 12 (CXCL12) and CXCR4 expression in endometrial tissue from both women with without abnormal uterine bleeding (AUB) of origin evaluate their relationship microRNA (miRNA).Retrospective laboratory study.University-based research laboratory.Nine bleeding, all whom were the secretory stage menstrual cycle, who provided biopsy tissue.Immunohistochemical localization CXCL12 as well quantitative reverse-transcription polymerase chain reaction (qRT-PCR) assessment...