A5101744774- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Virus-based gene therapy research
- Supercapacitor Materials and Fabrication
- Technology and Security Systems
- Metabolism, Diabetes, and Cancer
- Animal Virus Infections Studies
- Electromagnetic wave absorption materials
- Cholangiocarcinoma and Gallbladder Cancer Studies
- GDF15 and Related Biomarkers
- Cancer Research and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Cellular Mechanics and Interactions
- Liver Disease Diagnosis and Treatment
- Synthetic Aperture Radar (SAR) Applications and Techniques
- HVDC Systems and Fault Protection
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
Shandong Agricultural University
2020-2025
Chang'an University
2019-2025
Ministry of Natural Resources
2025
Ministry of Agriculture and Rural Affairs
2025
Ningbo University Affiliated Hospital
2021-2024
Chinese People's Liberation Army
2024
Changchun University of Technology
2024
XinHua Hospital
2020-2024
Shanghai Jiao Tong University
2021-2024
Simcere Pharmaceutical (China)
2021-2024
Abstract N 6 -methyladenosine (m A) modification can alter gene expression by regulating RNA splicing, stability, translocation, and translation. Emerging evidence shows that m A plays an important role in cancer development progression, including cell proliferation, migration invasion, apoptosis, autophagy, drug resistance. Until now, the of mediated autophagy resistance is still unclear. In this study, we found methyltransferase METTL3-mediated played reversing gefitinib β-elemene...
The Heifangtai Loess terrace in northwest China is frequently affected by landslides due to hydrological factors, establishing it as a significant research area for loess landslides. Advanced time-series InSAR technology facilitates the retrieval of surface deformation information, thereby aiding monitoring landslide status. However, existing methods that analyze patterns do not fully exploit displacement time series derived from InSAR, which hampers exploration potentially coexisting within...
Artificial lands or islands reclaimed from the sea due to their vast land spaces and air are suitable for construction of airports, harbors, industrial parks, which convenient human cargo transportation. However, settlement process reclamation foundation is a problem public concern, including soil consolidation water recharge. Xiamen New Airport, one largest international airports in China, has been under on marine three years. At present, airport reached second phase construction, occupying...
N6-methyladenosine (m6A) RNA methylation regulators play a regulatory role in tumor pathogenesis and development. However, the of m6A regulator genes ovarian cancer (OC) has not been fully elucidated. This study aims to investigate mRNA expressions, clinicopathological features, prognostic values OC. Here, we demonstrate that 17 are differentially expressed normal tissues. By using consensus clustering, all patients can be divided into two subgroups (cluster 1 2) based on expression...
The gonad of jellyfish (Rhopilema esculentum Kishinouye), containing high protein content with a rich amino acid composition, is suitable for the preparation bioactive peptides. Jellyfish was hydrolysed neutral protease to obtain hydrolysate (JGPH), which then purified sequentially by ultrafiltration, gel filtration chromatography, and RP-HPLC. peptides were characterized HPLC-MS/MS. One peptide sequence Ser-Tyr (SY) identified synthesized, showed good ACE inhibitory antioxidant activity....
Intramuscular fat (IMF) content is an important factor in porcine meat quality. Previously, we showed that miR-34a was less abundant liver tissue from pigs with higher backfat thickness, compared to lower thickness. The purpose of this present study explore the role adipogenesis.Bioinformatics analysis identified Acyl-CoA synthetase long chain family member 4 (ACSL4) as a putative target miR-34a. Using luciferase reporter assay, verified binds ACSL4 mRNA at 3'UTR. To examine miR-34a-ACSL4...
Hydrogel-based supercapacitors are an up-and-coming candidate for safe and portable energy storage. However, it is challenging hydrogel electrolytes to achieve high conductivity rapid self-healing at subzero temperatures because the movements of polymer chains reconstruction capability broken dynamic bonds limited. Herein, a highly conductive proton polyacrylamide-phytic acid (PAAm-PA) electrolyte with autonomous ability excellent adhesion over wide temperature range developed. PA, as donor...
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most harmful pathogens in swine industry. Our previous studies demonstrated that small extracellular domain (ECL2) CLDN4 effectively blocks PRRSV infection. In this study, we explored vivo administration ECL2 (sECL2) found it blocked HP-PRRSV infection alleviated histopathological changes organs. Notably, sECL2 stimulated cytokine production lungs. We observed upregulated expression IFN-β at low doses GP3....
Intramuscular fat (IMF) not only directly affects the tenderness, juiciness, and overall flavour of meat but also plays a significant role in influencing consumer preferences for pork. Therefore, exploring key biomarkers that influence IMF deposition is highly important breeding high-quality typical quantitative trait regulated by interaction multiple coding noncoding RNAs. Traditional differential analysis methods typically focus on individual genes, making it difficult to identify genes...
<i>Background:</i> The isoflavone puerarin is the most abundant isoflavone-C-glucoside extracted from root (radix puerariae) of plant <i>Pueraria lobata</i> and possesses many biological activities. In this report, ability to modulate intercellular adhesion molecule 1 (ICAM-1), vascular cell (VCAM-1) endothelial leukocyte (E-selectin), induce changes in nuclear factor ĸB (NF-ĸB) pathway human umbilical vein cells (HUVECs) was examined. <i>Methods:</i>...
Abstract Carbodiimide cross‐linked silk fibroin (SF)/sodium alginate (SA) composite hydrogels with superior stability and tunable properties are developed by varying preparation parameters. SF/SA blend ratio modulation allows to achieve hydrogel gelation times of 18–65 min, rheological analysis shows that the speed gel formation, network's density, hydrogels’ compressive closely related ratio. The G ′ different varies substantially from 28 413 Pa, higher SF content has a greater stiffness....
Non-SMC condensin I complex subunit G (NCAPG), a member of the complex, is significantly overexpressed in various cancers and involved pathogenesis cancers. However, roles NCAPG ovarian cancer remain unclear. The mRNA expression, overall survival, disease-free survival were analyzed by GEPIA KM plotter database, expression levels OC tissues cell lines determined qPCR immunohistochemistry analysis. shRNA targeting gene (sh-NCAPG) was utilized to knock down OVCAR3 SKOV3 cells. Subsequently,...
<abstract> Heart failure (HF), a common disease in adults, accounts for significantly global morbidity and mortality. Due to population aging, therapeutic progression acute cardiovascular events, the prevalence of HF is increasing, spite efficacy multiple therapies patients with decreased ejection fraction. Despite great progress underlying molecular mechanisms, it remains incompletely clear function competing endogenous RNA (ceRNA) network pathogenesis. Herein, we established an HF-related...
In this article, the selective inhibition of several tyrosine-containing dipeptides on N and C domain ACE (angiotensin-converting enzyme) was studied, interaction mode inhibitors simulated by molecular docking. MTT assay used to detect effect dipeptide human umbilical vein endothelial cells (HUVEC). The results showed that food-derived AY (Ala-Tyr), LY (Leu-Tyr), IY (Ile-Tyr) containing tyrosine at C-terminal were favorable structures for C-domain. These competitive mixed patterns, while EY...
The alignment of business strategies with the United Nations' Sustainable Development Goals has become increasingly essential. Companies are now required to adopt robust mechanisms track and report on sustainability performance. integration KPIs based a sustainable development balanced scorecard directly addresses this need, offering structured framework for embedding metrics into enterprise management systems. process developing implementing fosters culture innovation continuous...
Porcine reproductive and respiratory syndrome viru