A5101525249- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Cardiomyopathy and Myosin Studies
- RNA modifications and cancer
- Natural Fiber Reinforced Composites
- Advanced Cellulose Research Studies
- GDF15 and Related Biomarkers
- RNA Research and Splicing
- Lignin and Wood Chemistry
- Virus-based gene therapy research
- Microbial Metabolites in Food Biotechnology
- Advanced biosensing and bioanalysis techniques
- Cardiovascular Disease and Adiposity
- Toxin Mechanisms and Immunotoxins
- Cancer-related gene regulation
- HVDC Systems and Fault Protection
- Heusler alloys: electronic and magnetic properties
- Tissue Engineering and Regenerative Medicine
- Meat and Animal Product Quality
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Advanced Thermoelectric Materials and Devices
Fujian Agriculture and Forestry University
2024-2025
Dalian Polytechnic University
2021-2025
North Minzu University
2025
State Ethnic Affairs Commission
2025
Chinese Academy of Sciences
2016-2024
Institute of Zoology
2016-2024
China Medical University
2024
First Hospital of China Medical University
2024
State Key Laboratory of Stem Cell and Reproductive Biology
2024
Dalian Medical University
2023-2024
N6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs and plays important roles in various biological processes. The formation of m6A catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as key factor. However, vivo functions METTL3 mammalian development remain unclear. Here, we show that specific inactivation Mettl3 mouse nervous system causes severe developmental defects brain. conditional knockout (cKO) mice manifest cerebellar...
Silanized aluminum borate whiskers (ABWs) of 4 wt%, silanized zirconium dioxide nanoparticles (nano-ZrO2) 2 wt% were mixed with polymethyl methacrylate (PMMA) powder to get ZrO2-ABWs/PMMA composites. Titanium (TiO2), silver-supported titanium (Ag/TiO2), phosphate (Novaron) and tetrapod-like zinc oxide (T-ZnOw) antibacterial agents 3 composites respectively fabricate standard specimens. Plaque biofilms on the specimens surface investigated for colony-forming units (CFUs). In addition,...
All-RNA-mediated targeted gene integration methods, rendering reduced immunogenicity, effective deliverability with non-viral vehicles, and a low risk of random mutagenesis, are urgently needed for next-generation addition technologies. Naturally occurring R2 retrotransposons hold promise in this context due to their site-specific profile. Here, we systematically analyzed the biodiversity elements screened several orthologs capable full-length insertion mammalian cells. Robust system...
Histone deacetylase 10 (HDAC10) is a member of the class II HDACs, and its role in cancer emerging. In this study, we found that HDAC10 highly expressed lung tissues. It resides mainly cytoplasm cells but nucleus adjacent normal cells. Further examinations revealed multiple cell lines, including A549, H358 H460 epithelial 16HBE A leucine-rich motif, R505L506L507C508V509A510L511, was identified as nuclear localization signal (NLS), mutant (Mut-505-511) featuring mutations to at each original...
8-Oxoguanine DNA glycosylase1 (OGG1)-initiated base excision repair (BER) is the primary pathway to remove pre-mutagenic 8-oxo-7,8-dihydroguanine (8-oxoG) from DNA. Recent studies documented 8-oxoG serves as an epigenetic-like mark and OGG1 modulates gene expression in oxidatively stressed cells. For this new role of OGG1, two distinct mechanisms have been proposed: one coupled excision, while other only requires substrate binding OGG1––both resulting conformational adjustment adjacent...
Through a one-step hydrothermal method, we synthesized CCS- M ( = Cu/Co ratio) catalysts, with 0.5 showing optimal ORR performance. As an MFC cathode, it achieved 200.08 mW m −2 power density and stable 345 mV output.
A series of biochemical responses, including hypoxia and aseptic inflammation, occur in periodontal ligament cells (PDLCs) during tissue remodeling orthodontic tooth movement (OTM). However, the role long non-coding RNA (lncRNA) these responses is still largely unknown. We investigated lncRNA SNHG8 hypoxic inflammatory OTM explored underlying mechanisms.The expression pattern SNHG8, under compressive force were analyzed by qRT-PCR, immunohistochemistry, western blotting, vivo vitro. The...
The oxidative state of sunflower oil during high-temperature storage has been facing large challenges. In the study, antioxidant effect essential Angelica dahurica cv. Yubaizhi (ADEO) in was explored. for 24 days at 65 °C, ADEO (800 ppm) able to markedly inhibit development acid value (AV), peroxide (PV), p-anisidine (AnV), total oxidation (TOTOX), thiobarbituric reactive substances (TBARS), polar compounds (TPC), and absorbance 232 268 nm (p < 0.01 or p 0.05) prominently transformation...
Brown adipose tissue (BAT) plays a critical role in energy expenditure by uncoupling protein 1 (UCP1)-mediated thermogenesis. Carbohydrate response element-binding (ChREBP) is one of the key transcription factors regulating de novo lipogenesis (DNL). As constitutively active form, ChREBP-β expressed at extremely low levels. Up to date, its functional relevance BAT remains unclear. In this study, we show that inhibits mRNA levels were elevated upon cold exposure, which prompted us generate...
In this study, phycocyanin-sodium alginate/lysozyme complex (PC-SLC) was prepared for the first time and characterized by UV spectroscopy, Fourier transform infrared spectroscopy (FT-IR), circular dichroism (CD). The stability of PC-SLC under light, temperature, pH simulated gastrointestinal fluid investigated. scavenging ability complexes against DPPH ABTS radicals determined. results showed that formed mass ratio SA-LZM 0.1 highest PC encapsulation rate (89.9 ± 0.374%). combination SA LZM...
Mesenchymal stromal cells (MSCs) derived from human embryonic stem (hESCs) are a desirable cell source for therapy owing to their capacity be produced stably and homogeneously in large quantities. However, scalable culture system hPSC-derived MSCs is urgently needed meet the quantity quality requirements of practical clinical applications. In this study, we developed new microcarrier with hyaluronic acid (HA) as core material, which allowed serum-free suspension hESC-derived (IMRCs). We used...