A5038415536- Microbial Metabolic Engineering and Bioproduction
- Gut microbiota and health
- Enzyme Catalysis and Immobilization
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Smoking Behavior and Cessation
- Congenital Heart Disease Studies
- Animal Behavior and Welfare Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Health and Risk Factors
- Chronic Kidney Disease and Diabetes
- Genetics and Neurodevelopmental Disorders
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Nicotinic Acetylcholine Receptors Study
- Bipolar Disorder and Treatment
- Ocular Infections and Treatments
- Simulation-Based Education in Healthcare
- Cardiovascular Health and Disease Prevention
- Medicinal Plants and Neuroprotection
- Electrocatalysts for Energy Conversion
- Adenosine and Purinergic Signaling
- Nitric Oxide and Endothelin Effects
- Liver Disease Diagnosis and Treatment
Central People's Hospital of Zhanjiang
2022-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Academy of Medical Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
National Clinical Research
2024
China-Japan Friendship Hospital
2024
Capital Medical University
2024
Hunan Children's Hospital
2020-2023
China Agricultural University
2012-2023
Zhujiang Hospital
2013-2022
Luteolin is a flavonoid compound with variety of pharmacological effects. In this study, we explored the effects luteolin on monocrotaline (MCT) induced rat pulmonary arterial hypertension (PAH) and underlying mechanisms. A PAH model was generated through MCT injection. model, improved vascular remodeling right ventricular hypertrophy, meanwhile, could inhibit proliferation migration artery smooth muscle cells by platelet-derived growth factor-BB (PDGF-BB) in dose-dependent manner. Moreover,...
The prevalence of cigarette smoking among women is significantly different from that men, however, use by little known. study aims to describe and patterns Chinese females age province.
Epigenetic modification plays a key role in β cell senescence. In the regulation of gene expression, there is complex and close relationship between DNA methylation histone modification. order to explore its specific mechanism T2DM senescence, we used postbisulfite aptamer labeling genome-wide bisulfite-SEQ, chromatin immunocoprecipitation-SEQ, RNA-SEQ, CRISPR/Cas9 TETs knockout, RNA interference, TET2 inhibitors, lentiviral overexpression, knockout mouse models. Our study found that...
Epigenetic modification plays a key role in β cell senescence. In the regulation of gene expression, there is complex and close relationship between DNA methylation histone modification. order to explore its specific mechanism T2DM senescence, we used postbisulfite aptamer labeling genome-wide bisulfite-SEQ, chromatin immunocoprecipitation-SEQ, RNA-SEQ, CRISPR/Cas9 TETs knockout, RNA interference, TET2 inhibitors, lentiviral overexpression, knockout mouse models. Our study found that...
This study investigated the prevalence and determinants of hyperuricemia in Chinese type 2 diabetes mellitus (T2DM) patients with central obesity. A multicentric hospital-based cross-sectional was carried out Guangdong Province between August 2011 March 2012. At each hospital, T2DM obesity who were aged over 20 years, whose serum uric acid levels measured, had lived for >=1 year, recruited. Hyperuricemia defined as >420 μmol/L men >360 women. Binary logistic regression used to assess...
Pulmonary arterial hypertension (PAH), a fatal disease with an insidious onset and rapid progression, shows characteristics such as increases in pulmonary circulatory resistance pressure, progressive right heart failure. Shikonin can reduce ventricular systolic pressure chronically hypoxic mice. However, the mechanisms underlying protective effect of shikonin against PAH pathogenesis have only been sporadically identified. The present study evaluated whether inhibiting expression pyruvate...
The gene encoding a (2R,3R)-2,3-butanediol dehydrogenase from Rhodococcus erythropolis WZ010 (ReBDH) was over-expressed in Escherichia coli and the resulting recombinant ReBDH successfully purified by Ni-affinity chromatography. native form found to exist as monomer with calculated subunit size of 37180, belonging family zinc-containing alcohol dehydrogenases. enzyme NAD(H)-specific its optimal activity for acetoin reduction observed at pH 6.5 55 °C. temperature 2,3-butanediol oxidation were...
ABSTRACT INTRODUCTION: Epilepsy is a common chronic disease with transient brain dysfunction and critically influences the quality of patients' family life. The aim this study was to analyze effectiveness management style on life in children. METHODS: We randomized 130 children either intervention group (n = 65) or control 65). Family combined routine care applied within first 24 hours after admission, whereas only group. contains 3 steps: involve families into determine treatment plan,...
Ultrasound-targeted microbubble destruction (UTMD) is a novel adjuvant tumor therapeutic method by enhancing exogenous gene transfection to target tissues. This study aims investigate the role of microRNA-492 (miR-492) in non-small cell lung cancer (NSCLC) and further analyze effects UTMD-mediated miR-492 inhibitor on tumorigenesis.The expression was detected qRT-PCR. Co-transfection microbubbles with Lipofectamine 3000 performed achieve inhibition NSCLC cells. CCK-8 Transwell assay were...
R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. The aim this study was investigate effect mechanism ALA on platelets vivo. Sprague-Dawley (SD) male rats were intravenously administered with low-dose (20 mg/kg/d), high-dose (80 mg/kg/d) saline, respectively. Platelets count bone marrow smear evaluated expressions markers related apoptosis autophagy measured. Platelet...
Abstract Background Basic life support and advanced are essential emergency management skills for medical workers, pediatricians' first aid can be improved through knowledge training. Methods A controlled pre–post-intervention quasi-experimental study design was used. The setting a tertiary children's hospital in China. In November 2019, KSS model of learning developed tested, pediatric workers ( N = 1448) were trained with it. outcome measures based on an questionnaire devised by the...
Abstract Background: Predictors of compliance with aspirin in children following cardiac catheterisation have not been identified. The aim this study is to identify the caregivers’ knowledge, medication, and predictors Congenital Heart Disease (CHD) post-percutaneous transcatheter occlusion. Methods: A cross-sectional explorative design was adopted using a self-administered questionnaire conducted between May 2017 2018. Recruited were 220 caregivers CHD Questionnaires included child...
Abstract Epigenetic modification plays a key role in β cell senescence. In the regulation of gene expression, there is complex and close relationship between DNA methylation histone modification. order to explore its specific mechanism T2DM senescence, we used postbisulfite aptamer labeling genome-wide bisulfite-SEQ, chromatin immunocoprecipitation-SEQ, RNA-SEQ, CRISPR/Cas9 TETs knockout, RNA interference, TET2 inhibitors, lentiviral overexpression, knockout mouse models. Our study found...
Zinc-finger E-box-binding homeobox-1 (ZEB1) is predominantly found in type-H vessels. However, the roles of ZEB1 and vessels steroid-induced osteonecrosis femoral head (SONFH) are unclear.