A5100746495- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Blood groups and transfusion
- Blood disorders and treatments
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Autophagy in Disease and Therapy
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Complement system in diseases
- Alzheimer's disease research and treatments
- Acute Myeloid Leukemia Research
- Extracellular vesicles in disease
- Calcium signaling and nucleotide metabolism
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Long-Term Effects of COVID-19
- Mesenchymal stem cell research
- Parkinson's Disease Mechanisms and Treatments
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Parvovirus B19 Infection Studies
East China Normal University
2024-2025
Peking University
2011-2025
Peking Union Medical College Hospital
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
University of Chinese Academy of Sciences
2021-2024
X-Fab (Germany)
2024
Northwest Normal University
2024
Chongqing Institute of Green and Intelligent Technology
2024
Chinese Academy of Sciences
2004-2024
Jiangnan University
2024
OBJECTIVE Diabetes is one of the most distinct comorbidities COVID-19. Here, we describe clinical characteristics and outcomes in patients with diabetes whom COVID-19 was confirmed or clinically diagnosed (with typical features on lung imaging symptoms) their association glucose-lowering blood pressure–lowering medications. RESEARCH DESIGN AND METHODS In this retrospective study involving 904 (136 diabetes, mostly type 2 diabetes), laboratory were collected compared between group without...
The bacterial pathogen Legionella pneumophila exploits host cell vesicle transport by transiently manipulating the activity of small guanosine triphosphatase (GTPase) Rab1. effector protein SidM recruits Rab1 to Legionella-containing vacuole (LCV), where it activates and then AMPylates covalently adding adenosine monophosphate (AMP). L. GTPase-activating LepB inactivates before its removal from LCVs. Because cannot bind AMPylated Rab1, molecular events leading inactivation are unknown. We...
Abstract The outbreak of COVID-19 has become a worldwide pandemic. pathogenesis this infectious disease and how it differs from other drivers pneumonia is unclear. Here we analyze urine samples infection cases, healthy donors non-COVID-19 cases using quantitative proteomics. molecular changes suggest that immunosuppression tight junction impairment occur in the early stage infection. Further subgrouping patients into moderate severe types shows an activated immune response emerges severely...
Abstract Absorption, distribution, metabolism, excretion and toxicity (ADMET) properties play a crucial role in drug discovery chemical safety assessment. Built on the achievements of admetSAR its successor, admetSAR2.0, this paper introduced new version series, admetSAR3.0, as comprehensive platform for ADMET assessment, including search, prediction optimization modules. In search module, admetSAR3.0 hosted over 370 000 high-quality experimental data 104 652 unique compounds, supplemented...
BackgroundThe possibility of 2019 novel coronavirus disease (COVID-19) transmission to neonates through breast milk remains unverified.MethodsThis paper presents the interim results a longitudinal study being carried out in Hubei province. As 1 April 2020, 24 mothers confirmed with COVID-19, 19 suspected COVID-19 but Polymerase chain reaction negative, and 21 without their have been recruited. Telephone follow-up was conducted collect information on breastfeeding practices. Forty-four...
COVID-19 patients present high incidence of kidney abnormalities, which are associated with poor prognosis and mortality. The identification SARS-CoV-2 in the suggests renal tropism SARS-CoV-2. However, whether there is a specific target remains unclear. Herein, by using silico simulation, coimmunoprecipitation, fluorescence resonance energy transfer, fluorescein isothiocyanate labeling, rational design antagonist peptides, we demonstrate that injury molecule-1 (KIM1), molecule dramatically...
Acute liver injury is commonly caused by bacterial endotoxin/lipopolysaccharide (LPS), and drug overdose such as acetaminophen (APAP). The exact role of epigenetic modification in acute remains elusive. Here, we investigated the histone methyltransferase G9a LPS- or APAP overdose-induced injury. Under D-galactosamine sensitization, liver-specific G9a-deficient mice (L-G9a-/-) exhibited 100% mortality after LPS injection, while control L-G9a+/- littermates showed very mild mortality....
SARS-CoV-2 has caused a severe pneumonia pandemic worldwide with high morbidity and mortality. How to develop preclinical model for recapitulating pathogenesis is still urgent essential the control of pandemic. Here, we have established 3D biomimetic alveolus-on-a-chip mechanical strain extracellular matrix taken into consideration. We validated that capable key physiological characteristics human alveolar units, which lays fundamental basis viral infection studies at organ level. Using...
Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.529 (Omicron) has rapidly become the dominant strain, with an unprecedented number of mutations within its spike gene. However, it remains unknown whether these variants have alterations in their entry efficiency, host tropism, and sensitivity to neutralizing antibodies inhibitors. In this study, we found that Omicron evolved escape neutralization by three-dose inactivated-vaccine-elicited immunity but...
Abstract Proteins in the plasma/serum mirror an individual’s physiology. Circulating extracellular vesicles (EVs) proteins constitute a large portion of proteome. Thus, deep and unbiased proteomic analysis circulating holds promise for discovering disease biomarkers as well revealing mechanisms. We established workflow simple, deep, reproducible proteome both serum small EVs enriched fractions by ultracentrifugation plus 4D-data-independent acquisition mass spectrometry (4D-DIA-MS). In our...
Purpose The systemic inflammation response index (SIRI) has been reported to have prognostic ability in various solid tumors but not studied gallbladder cancer (GBC). We aimed determine its value GBC. Materials and Methods From 2003 2017, patients with confirmed GBC were recruited. To the SIRI's optimal cutoff value, a time-dependent receiver operating characteristic curve was applied. Univariate multivariate Cox analyses performed for recognition of significant factors. Then cohort randomly...