A5019615571- Dyeing and Modifying Textile Fibers
- Chemical Synthesis and Reactions
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- Medicinal Plant Studies
- Nutrition and Health in Aging
- Ubiquitin and proteasome pathways
- Skin Protection and Aging
- Carbon and Quantum Dots Applications
- Flame retardant materials and properties
- Cancer-related molecular mechanisms research
- Chemical Synthesis and Analysis
- Coordination Chemistry and Organometallics
- melanin and skin pigmentation
- Subtitles and Audiovisual Media
- Carbon dioxide utilization in catalysis
- Antibiotics Pharmacokinetics and Efficacy
- Extenics and Innovation Methods
- Textile materials and evaluations
- Linguistic Variation and Morphology
- Power Systems and Renewable Energy
- NF-κB Signaling Pathways
- Polydiacetylene-based materials and applications
- Chemical synthesis and pharmacological studies
- Lymphatic Disorders and Treatments
Tongren Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Central South University
2025
Guangxi University of Chinese Medicine
2017-2024
Weatherford College
2024
Guangxi Maternal and Child Health Hospital
2024
Huazhong University of Science and Technology
2019-2023
Hebei University of Science and Technology
2011-2023
First Affiliated Hospital of Zhengzhou University
2022
People’s Hospital of Rizhao
2015-2021
The integrative multiomics characterization of minute amounts clinical tissue specimens has become increasingly important. Here, we present an approach called Integral-Omics, which enables sequential extraction metabolites, lipids, genomic DNA, total RNA, proteins, and phosphopeptides from a single biopsy-level specimen. We benchmarked this method with various samples, applied the workflow to perform profiling tissues six patients colorectal cancer, found that tumor exhibited suppressed...
Acute liver injury is commonly caused by bacterial endotoxin/lipopolysaccharide (LPS), and drug overdose such as acetaminophen (APAP). The exact role of epigenetic modification in acute remains elusive. Here, we investigated the histone methyltransferase G9a LPS- or APAP overdose-induced injury. Under D-galactosamine sensitization, liver-specific G9a-deficient mice (L-G9a-/-) exhibited 100% mortality after LPS injection, while control L-G9a+/- littermates showed very mild mortality....
Tumor necrosis factor α (TNFα)‐ and interleukin 1β (IL‐1β)‐induced nuclear factor‐κB (NF‐κB) activation play key roles in inflammation, immunity, cancer development. Here, we identified one of the deubiquitinating enzymes (DUBs), ubiquitin‐specific protease 15 (USP15), as a positive regulator both TNFα‐ IL‐1β‐induced NF‐κB activation. Overexpression USP15 potentiated or IL‐1β‐triggered downstream gene transcription, whereas knockdown had opposite effects. Mechanistically, upon TNFα...
Natural dyes are environmentally friendly and have become important alternatives to synthetic in some dyeing products. Therefore, better extraction techniques need be developed for the process of natural dyes. In this work, cotton fabric was dyed using turmeric solution under an ultralow liquor ratio (materials 1:5) ultrasonic-assisted conditions. Dye different dispersants pH values has been investigated three-factor-three–level Box–Behnken design employed explore It found that sodium...
Coarse wool is a kind of goat that difficult to further process in the textile industry due its large diameter, dispersion, better strength, and less bending. Therefore, coarse often discarded as waste or made into low-cost products. In this work, keratin was extracted from by high-efficiency method, then, an Ag-doped keratin/PA6 composite nanofiber membrane with enhanced filtration antibacterial performance prepared using HCOOH solvent reductant. HAADF-STEM (high-angle annular dark...
ABSTRACT Oxidized low‐density lipoprotein (ox‐LDL)‐induced endothelial dysregulation and the abnormal interaction between monocytes have been considered key risk factors for atherosclerosis. The study investigated effects of apelin‐13 on ox‐LDL‐induced dysfunction in human aortic cells (HAECs). Cells were stimulated with ox‐LDL (100 mg/L), either alone or combination at concentrations 3 6 µM. Multiple techniques, including real‐time PCR, Western blot analysis, enzyme‐linked immunosorbent...
Abnormalities of methyl-CpG binding protein 2 (Mecp2) cause neurological disorders with metabolic dysfunction; however, its role in adipose tissues remains unclear. Here, we report upregulated Mecp2 white (WAT) obese humans, as well mice and during vitro adipogenesis. Normal chow-fed adipocyte-specific knockout (Mecp2Adi KO mice) showed a lean phenotype, downregulated lipogenic genes thermogenic that were identified using RNA sequencing. Consistently, the deficiency adipocytes protected from...
Abstract Interleukin-1β (IL-1β)-induced signaling is one of the most important pathways in regulating inflammation and immunity. The assembly receptor complex, consisting ligand IL-1β, IL-1 (IL-1R) type 1 (IL1R1), IL-1R accessory protein (IL1RAP), initiates this signaling. However, how IL1R1-associated complex regulated remains elusive. Angiopoietin like 3 (ANGPTL3), a key inhibitor plasma triglyceride clearance, mainly expressed liver exists both intracellular extracellular secreted forms....
To explore the effect of holographic Guasha therapy on Pittsburg Sleep Quality Index (PSQI) and Hamilton Anxiety Rating Scale (HAMA) in older adults with hypertension living community. This prospective study was conducted from July 2019 to December 2020. Older (systolic pressure ≥ 140 mm Hg, diastolic 90 Hg) were divided into control groups. The PSQI HAMA assessed before after 4 weeks intervention. 62 patients enrolled, 31/group (Guasha: 72.4 ± 6.9 years, 23.0 3.1 kg/m2; control: 71.4 6.3...
Abstract Purpose The bone marrow niche plays an important role in leukemia development. However, the contributions of different components to development and their underlying mechanisms remain largely unclear. Method Cre/LoxP-based conditional knockout technology was used delete VPS33B or ANGPTL2 gene cells. Murine B-ALL model established by overexpressing N-Myc oncogene hematopoietic stem progenitor frequency cells immunophenotypic B220 + CD43 LICs detected flow cytometry. SEVs isolated...
The aim of the present study was to determine association between expression myelin basic protein in serum and metastasis lung cancer brain. A total 68 patients, treated Department Respiratory Medicine People's Hospital Rizhao (Rizhao, China), were divided into two groups, those with brain (32 cases) without (36 cases). levels measured for all patients. results indicated that group significantly higher when compared (P<0.05). However, there no statistically significant correlation size...
Abstract The integrative multi-omics characterization of minute amount clinical tissue specimens has become increasingly important. Here, we present an approach called Integral-Omics, which enables sequential extraction metabolites, lipids, genomic DNA, total RNA, proteins, and phosphopeptides from a single biopsy-level specimen. We benchmarked this method with various samples applied the workflow to perform profiling tissues six patients colorectal cancer found that tumor exhibited...
An efficient and rapid procedure for the conversion of various carboxylic acid derivatives into corresponding gem-bisallylated compounds under mild reaction conditions has been developed. Zinc-copper couple mediating Barbier- type addition derivative was utilized as a key operation to affect transformation. The is operationally simple, giving good high product yield. Keywords: couple, solvent-free, alcohols, allyl bromide
With the extensive use of dialysis catheters in patients undergoing hemodialysis, superior vena cava (SVC) syndrome has gradually attracted attention recent years. Chylothorax caused by SVC is rarely reported. In this paper, we report a case chylothorax secondary to obstruction (SVCO) maintenance hemodialysis patient after multiple catheter placements. Relieving SVCO through intravascular intervention could effectively treat chylothorax. past fourteen months, no recurrence symptoms been observed.
Objective To investigate the association of nutritional risk screening scores with lower respiratory tract infections and cardiac function grading in patients chronic heart failure(CHF). Methods Records 108 CHF recruited from January 2013 to 2014 at our hospital were analyzed retrospectively.Patients divided into observation group control group.The included 54 infections, while without infections.Nutritional was performed accordance Nutritional 2002 for all participants, therapy rate...