A5026455543- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- RNA Interference and Gene Delivery
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Vascular Malformations and Hemangiomas
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Spondyloarthritis Studies and Treatments
- Infection Control and Ventilation
- Rheumatoid Arthritis Research and Therapies
- COVID-19 and healthcare impacts
- Nanoplatforms for cancer theranostics
- Gastrointestinal Bleeding Diagnosis and Treatment
- Lipid metabolism and disorders
- Gastric Cancer Management and Outcomes
- Photoacoustic and Ultrasonic Imaging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hippo pathway signaling and YAP/TAZ
- Gastrointestinal disorders and treatments
- Vascular Tumors and Angiosarcomas
- Laser Applications in Dentistry and Medicine
- RNA Research and Splicing
- Liver physiology and pathology
Huazhong University of Science and Technology
2009-2024
Union Hospital
2005-2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Xiangya Hospital Central South University
2022-2024
Central South University
2022-2024
Wuhan Union Hospital
2012-2024
Peking University
2024
Central Hospital of Wuhan
2018-2023
Fujian Medical University
2007-2023
Abstract: Purpose : Regulatory T cells (T‐reg) that control harmful autoimmune in the periphery may also suppress immune response against cancer. In this study we investigated possible involvement of CD4 + CD25 high T‐reg impairment patients with acute myeloid leukemia (AML). Experimental design The frequencies and phenotypes peripheral blood AML were determined by flow cytometry. To assess functional activity cells, , − sorted from mononuclear FACS Vantage. immunoregulatory properties...
Tumor necrosis factor α (TNFα)‐ and interleukin 1β (IL‐1β)‐induced nuclear factor‐κB (NF‐κB) activation play key roles in inflammation, immunity, cancer development. Here, we identified one of the deubiquitinating enzymes (DUBs), ubiquitin‐specific protease 15 (USP15), as a positive regulator both TNFα‐ IL‐1β‐induced NF‐κB activation. Overexpression USP15 potentiated or IL‐1β‐triggered downstream gene transcription, whereas knockdown had opposite effects. Mechanistically, upon TNFα...
Rationale: The development of a highly effective and tumor-specific therapeutic strategy, which can act against the primary tumor also condition host immune system to eliminate distant tumors, remains clinical challenge. Methods: Herein, we demonstrate facile yet versatile ZnO-capping Doxorubicin (DOX)-loaded multifunctional nanocomposite (AuNP@mSiO2@DOX-ZnO) that integrates photothermal properties gold nanoparticles (NPs), pH-responsive preferential selectivity cells ZnO QDs...
Malignant melanoma (MM) is a major public health problem. The development of effective, systemic therapies for MM highly desired. We showed here that the transferrin receptor (TfR) was suitable surface marker targeting gene therapy in and hypoxia-inducible factor-1alpha (HIF-1alpha) an attractive therapeutic molecular target MM. observed inhibition HIF-1alpha blocked cell proliferation induced apoptosis vitro. then transferrin-polyethylenimine-HIF-1alpha-short-hairpin RNA...
Abstract New WHO classification has been widely applied in the diagnosis of leukemia. To elucidate immunophenotype acute myeloid leukemia (AML) and characterize correlation among morphological, immunological, cytogenetic, clinical features, we studied bone marrow immunophenotypes 180 AML patients China by flow cytometry. The results showed that CD34, CD2, CD14, CD19, CD56, HLA‐DR were correlated with FAB subtypes. Amongst enrolled this study, 122 cases also subjected to karyotype analysis...
Abstract Objective To evaluate the clinical features of and to identify pathogen responsible for an outbreak acute dermatitis in a toy‐building factory Chibi city, central China. Methods Physical examinations were carried out on all staff. Records made. The district, its surrounding environment accommodation conditions investigated. insects collected area identified by parasitologist at Department Parasitology, Tongji Medical College, Huazhong University Science Technology, Wuhan. Results...
Gastrointestinal stromal tumor (GIST) is a rare of the small bowel, which can be difficult to diagnose and has varied clinical outcome.This retrospective review diagnosis, management, outcome 32 patients diagnosed with primary bowel GIST from single center comparison findings previously published cases.Retrospective data patient records, endoscopic imaging findings, surgical procedures, histology immunohistochemistry, was conducted.Data median age 56 years including 50% men women were...
Abstract Backgrounds Striae distensae ( SD ) has a known psychological impact due to the resulting cosmetic disfigurement. Many treatment modalities have been used over years, but no standard interventions or evaluation methods proposed date. Objective We compared efficacy and safety of non‐insulated microneedle radiofrequency NIMRF fractional CO 2 laser treatments by objective measurements with dermoscopy VISIA . Methods Fourteen females severe were enrolled. These subjects had treated...
Liver fibrosis is a tissue repair process that occurs following various types of chronic liver injury and can develop into cirrhosis, portal hypertension or cancer without effective treatment. Shikonin has anti-inflammatory, antiviral antitumor properties. Furthermore, shikonin an additional effect antagonizing organ fibrosis. The aim the present study was to evaluate mechanisms action underlying against Cell viability assessed using Counting Kit-8 EdU incorporation assays. Protein mRNA...
Summary Background The Q ‐switched alexandrite laser used at 752 nm, a wavelength well absorbed by melanin relative to other optically absorbing structures in skin, causes highly selective destruction of pigment‐laden cells. In addition, the 75‐nanosecond pulse duration produced this approximates thermal relaxation time for melanosomes, thereby confining energy target. Facial and labial dark brown macules quickly identify patients with P eutz– J eghers syndrome. These lentigines may be...
Abstract Interleukin-1β (IL-1β)-induced signaling is one of the most important pathways in regulating inflammation and immunity. The assembly receptor complex, consisting ligand IL-1β, IL-1 (IL-1R) type 1 (IL1R1), IL-1R accessory protein (IL1RAP), initiates this signaling. However, how IL1R1-associated complex regulated remains elusive. Angiopoietin like 3 (ANGPTL3), a key inhibitor plasma triglyceride clearance, mainly expressed liver exists both intracellular extracellular secreted forms....
Both colorectal and gastric cancer are lethal solid-tumor malignancies, leading to the majority of cancer-associated deaths worldwide. Although (CRC) (GC) share many similarities, prognosis drug response CRC GC different. However, determinants for such differences have not been elucidated. To avoid genetic background variance, we performed multi-omics analysis, including single-cell RNA sequencing, whole-exome microbiome dissect tumor immune signature synchronous primary tumors CRC. We found...
The aim of this study was to compare perioperative outcomes patients with low rectal cancer after stoma-site approach single-port laparoscopic Miles procedure or conventional multi-port procedure, as well evaluate the safety and efficacy surgery in cancer. Between September 2020 2021, 51 scheduled for at Department Gastrointestinal Surgery Affiliated Hospital North Sichuan Medical College were randomly assigned group (SPLS) (MPLS) group. compared between two groups. In study, 25 underwent...
The most characteristic change in psoriasis is markedly increased, persistent keratinocyte proliferation. pathogenic mechanism underlying the hyperproliferation of keratinocytes still not completely clarified. Cellular FLIP (cFLIP) a close homologue caspase 8 without activity that inhibits Fas signaling. cFLIP protein often expressed human tumors and believed to suppress antitumor immune responses involving system. PCNA an auxiliary DNA polymerase-5, which appears early G1 becomes more...
As the implantation and long-term existence of tumor-specific T cells in host are prerequisite for adoptive immunotherapy, memory stem (TSCM) with self-renewal differentiation capacity show greatest potential to implant exhibit function vivo, compared other stages. Hence, TSCM have become candidate cell therapy cancer. Here, we reported a protocol generate allogeneic antigen-specific CD8+ from human PBLs. To prepare TSCM, used an LCL named E007 defined HLA allotyping as simulator, co-culture...
Psoriasis can be provoked or exacerbated by environmental exposures such as certain microbiomes. The distinction between plaque psoriasis (PP) and guttate (GP) in the skin pharyngeal microbiota is not yet clear. High-throughput sequencing using Illumina MiSeq was used this study to characterize microbial composition patients with PP [large (LPP, n = 62), small (SPP, 41)] GP (n 14). alpha- beta-diversity of LPP similar that SPP group, but different from group. There were no differences among...
Abstract Background There is still no consensus on the preferred endoscopic therapy for small bowel angioectasias (SBAs). The aim of this study was to evaluate effectiveness and safety injection sclerotherapy (EIS) treating recurrent bleeding SBAs. Methods Sixty-six adult patients diagnosed with SBAs by capsule endoscopy (CE) or double-balloon enterscopy (DBE) examinations were enrolled in retrospective from September 2013 2021. divided into an EIS group (35 cases) a control (31 according...