A5090170346- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Psoriasis: Treatment and Pathogenesis
- Analytical Chemistry and Sensors
- Characterization and Applications of Magnetic Nanoparticles
- Electrochemical sensors and biosensors
- Cyclopropane Reaction Mechanisms
- Geochemistry and Geologic Mapping
- Catalytic Alkyne Reactions
- Water Quality Monitoring and Analysis
- Heavy metals in environment
- Dermatology and Skin Diseases
- Spondyloarthritis Studies and Treatments
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune Cell Function and Interaction
- Mast cells and histamine
- Mining and Resource Management
- Autoimmune and Inflammatory Disorders Research
- Mass Spectrometry Techniques and Applications
- Complementary and Alternative Medicine Studies
- Advanced Chemical Sensor Technologies
- Genetic factors in colorectal cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
University of South China
2024
Chinese Academy of Medical Sciences Dermatology Hospital
2022-2024
China Geological Survey
2020-2024
Chinese Academy of Geological Sciences
2020-2024
Second Xiangya Hospital of Central South University
2024
Xiangtan University
2021-2023
Xiangya Hospital Central South University
2020-2023
Central South University
2020-2023
Anhui Normal University
2021-2023
An efficient novel visible-light photoredox-catalyzed dual carbon-carbon bond cleavage of methylenecyclopropanes and cycloketone oximes for the synthesis 2-cyanoalkylsulfonated 3,4-dihydronaphthalenes through insertion sulfur dioxide is established. This bonds involves a radical pathway goes sequence iminyl formation, cleavage, insertion, sulfonyl addition, another intramolecular cyclization.
Abstract Psoriasis is a common, chronic immune-mediated systemic disease that had no effective and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory properties. Therefore, we performed phase 1/2a, single-arm clinical trial to evaluate the safety efficacy of human umbilical cord-derived MSCs (UMSCs) in treatment psoriasis preliminarily explore possible mechanisms. Seventeen patients with were enrolled received UMSC infusions. Adverse events, laboratory parameters, PASI,...
A novel visible-light-mediated ipso-carboacylation of N-(p-methoxyaryl)propiolamides with acyl chloride has been established for the synthesis diverse 3-acylspiro[4,5]trienones high selectivity and efficiency. This method represents a new difunctionalization alkynes through cross coupling C-Cl bonds an ipso-aromatic carbon by simultaneously forming two carbon-carbon one carbon-oxygen double bond.
A novel visible-light promoted sulfonylation/<italic>ipso</italic>-cyclization of <italic>N</italic>-arylpropiolamides with aromatic amines and DABCO·(SO<sub>2</sub>)<sub>2</sub> to synthesize various sulfonated spiro[4,5]trienones is reported.
The visible light-induced oxidative radical cascade coupling of N -arylacrylamides with aldehydes using bromide as the hydrogen atom transfer agent to synthesize functional oxindoles is described.
Macrophage-associated inflammation and keratinocytes excessive proliferation inflammatory cytokines secretion induced by stimulation play an important role in the progression of psoriasiform dermatitis. However, how these two types cells communicate remains obscure.
Herein, we disclosed a highly efficient pathway toward 3-selenylated chromone derivatives via electrocatalytic cascade selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amendable to scale-up the reaction. Additionally, preliminary experiments revealed that reaction probably proceeded cation instead...
A novel visible-light-catalyzed sulfonylation/arylation of carbon–carbon σ-bond with sulfonyl chlorides for the synthesis 3-sulfonylated 1,2-dihydronaphthalenes is developed. This difunctionalization proceeds via a sequence C═C bond sulfonylation, C–C cleavage, and intramolecular cyclization, experiment result shows that reaction includes radical process. strategy provides simple convenient route bonds an aromatic carbon by one-pot construction C–S new bond.
Abstract Background The small intestine harbors a rich array of intestinal intraepithelial lymphocytes (IELs) that interact with structural cells to collectively sustain gut immune homeostasis. Dysregulation homeostasis was implicated in the pathogenesis multiple autoimmune diseases, however, whether this is disrupted lupus background remains unclear. Methods We performed single-cell RNA sequencing (scRNA-seq) analyses elucidate and milieu epithelium MRL/Lpr mice (Lpr mice) MRL/Mpj control...
A simple and efficient visible-light-catalyzed cascade sulfonylation/cyclization of <italic>N</italic>-propargylindoles with K<sub>2</sub>S<sub>2</sub>O<sub>5</sub> aryldiazonium tetrafluoroborates for the construction 2-sulfonyl-substituted 9<italic>H</italic>-pyrrolo[1,2-<italic>a</italic>]indoles is developed.
A new FeCl2- and DTBP (di-tert-butyl peroxide)-promoted oxidative ring-opening cyclization of methylenecyclopropanes with aldehydes for the synthesis 2-acyl-3,4-dihydronaphthalenes is presented. This reaction proceeds via a radical addition, ring-opening, sequence facilitated by Lewis acid, it offers practical straightforward route an aromatic carbon C(sp2)–H bond simultaneously forming two carbon–carbon bonds.
The novel AgNO<sub>3</sub>-mediated sulfonylation/arylation of a C–C σ-bond in MCPs with sodium sulfinates to synthesize 3-sulfonylated 1,2-dihydronaphthalenes is reported.
A novel and convenient visible light-catalyzed tandem radical cyclization of N-propargylindoles with acyl chlorides for accessing 2-acyl-9H-pyrrolo[1,2-a]indoles is established. This transformation involves sequential addition the to carbon-carbon triple bond, intramolecular 2-position indole, isomerization double bond. The experimental results show that this reaction contains a pathway chain process not major formation products.
A visible-light induced direct C(sp3)-H functionalization of alkylarenes with trifluoromethyl ketones has been reported to access valuable benzyl-substituted alcohols in a stoichiometric manner. Readily available petroleum-derived are employed as latent benzylation reagents. With bromine radical the hydrogen atom transfer reagent, primary, secondary, and tertiary benzyl C–H bonds suitable coupling partners. Additionally, late-stage modification bioactive molecules highlights potential...
Abstract Background A Chinese herbal formula, Yi-Qi-Fu-Sheng (YQFS), has long been employed clinically to treat cancer patients. We aimed determine its effectiveness as a treatment method for colorectal cancer. investigated the therapeutic effects of YQFS on cancer, well underlying mechanisms, which have not previously explored. Methods First, was extracted and chemically characterized. then tested proliferation migration by MTT transwell assays in vitro . Mouse xenograft models were...
A novel metal-free oxidative ring-opening/cyclization of methylenecyclopropanes with ethers was established for the synthesis diverse 2-substituted 3,4-dihydronaphthalenes high selectivity and efficiency. This cyclization is achieved by C(sp3)-H functionalization, ring-opening, cyclization, this method represents a new example methylenecyclopropane an aromatic carbon bond simultaneously forming two carbon–carbon bonds.
An efficient and convenient strategy to synthesize diverse 3-sulfonylspiro[4,5]trienones has been developed. This ipso-carbosulfonylation of alkynes proceeds by visible-light catalysis under transition-metal-free conditions represents a new sulfonylation ipso-cyclization alkynes. In this transformation, the O atom in newly generated carbonyl is derived from H2O it features broad substrates scope, especially for alkyl propiolamides aliphatic sulfonyl chlorides.
The unique combination of photocatalysis, bromo radical mediation, and aerobic oxidation proved to be the key for successfully achieving cross-dehydrogenative coupling reaction.
The unique merger of photocatalysis, nickel catalysis and bromo radical-enhanced HAT proved to be the key success stoichiometric couplings methylarenes aryl bromine.
Sustainable photoredox catalysis with bromine radical-mediated hydrogen atom transfer enables stoichiometric pyridylation to synthesize a wide range of diarylmethanes and triarylmethanes in good excellent yields.