A novel ruthenium-catalyzed [5 + 1] annulation of 2-alkenylanilines with sulfoxonium ylides was developed for the rapid assembly highly functionalized quinolines. This new catalytic process employs challenging but synthetically ideal free amino functionality to achieve alkenyl C–H activation as one-carbon coupling partners. Various 2-acylquinolines could be obtained good yields and excellent functional group tolerance. Moreover, potential synthetic application this methodology exemplified by...

A selective three-component 1,2-sulfonyl etherification of aryl 1,3-dienes enabled by copper catalysis to afford biologically interesting alkenyl 1,2-sulfone ether derivatives through C–S and C–O bond formation is described. The protocol proceeds with the sulfonyl chloride alcohols under simple, mild, base-free conditions, providing a straightforward route sulfonylated allyl compounds broad functional group tolerance excellent chemo- regioselectivity. Mechanistic studies indicate that alkene...

Abstract Solar‐driven interfacial evaporation is a promising technology for desalination. The photothermal conversion materials are at the core and play key role in this field. Design of based on organic dyes desalination still challenge due to lack efficient guiding strategy. Herein, new D (donor)‐A (acceptor) type conjugated tetraphenylpyrazine (TPP) luminophore (namely TPP‐2IND) was prepared as molecule. It exhibited broad absorption spectrum strong π – stacking solid state, resulting...

PEG-stabilized rhodium nanoparticles exhibited high activity, selectivity and recyclability for the hydrogenation of quinoline its derivatives.

Abstract Iron‐mediated radical cyanoalkylsulfonylation/arylation of active olefins with cycloketone oxime derivatives via cleavage C−C single bond and insertion SO 2 is developed for the preparation cyanoalkylsulfonylated oxindoles. This difunctionalization carbon−carbon double a pathway involves cyclobutanone ester fragmentation, sulfonyl generation addition/5‐ exo cyclization. The methodology displays good functional group tolerance does not require any external bases or oxidants. magnified image

Abstract A nitrogen‐centered radical strategy for the preparation of 3‐acylated spiro[4,5]trienones via visible‐light‐mediated acylation/ ipso ‐cyclization alkynes with acyl oxime esters is reported. The alkyl‐ and aryl‐substituted radicals, which generate from cleavage carbon‐carbon σ ‐bonds in pathway, attack triple bonds propiolamides then undergo ‐cyclization. This method provides a way construction 3‐acyl‐substituted spiro[4,5]trienones, can introduce aryl‐ or alkyl‐substituted into...

A visible-light-mediated tandem cyanoalkylsulfonylation/cyclization of alkynoates with cycloketone oxime compounds for the preparation 3-cyanoalkylsulfonylcoumarins via SO2 insertion is reported. The difunctionalization carbon-carbon triple bonds includes a radical mechanism and involves formation an iminyl radical, ring-opening cycloketone, SO2, addition sulfonyl to bonds, ipso-cyclization ester migration.

Most organic mechanochromic luminogens show bathochromic-shifted and quenched emission with increasing pressure. Design of turn-on material hypsochromic-shifted luminescence is still a challenge. Herein, novel emitter (namely DCzPy) was prepared through laboratory-synthesized carbazole to study its stimuli-responsive luminescence. The crystalline powders DCzPy emitted blue-green fluorescence at 490 nm. Upon gently grinding, the intensity dramatically enhanced hypsochromic shift by 33 Further...

Herein, we develop photodynamic therapy (PDT)-accelerated supramolecular nanomaterials based on α-cyclodextrin (α-CD), red-emitting AIEgens (namely, TPE-Py) and a hypoxia-activated paclitaxel-based prodrug PTX-NB), which surpasses hypoxia limitations enhances the efficiency of chemotherapeutic release in melanoma. The cationic AIEgen functions as guest molecule, capable forming complex with α-CD 1:1 binding ratio, showing an increased fluorescence intensity. Interestingly, such accelerates...

A copper-based catalytic system has been described to enable the efficient 1,4-sulfonylindolylation of 1,3-dienes with sulfonyl chloride and indoles. This protocol offers a practical method for synthesis allylsulfone-containing indole derivatives broad range compatible functionalities excellent chemo- regioselectivities. Mechanistic studies suggest that copper catalyst plays dual role initiating radicals prompting coupling in this conjugated diene-selective 1,4-difunctionalization strategy.

A simple and efficient visible-light-catalyzed cascade sulfonylation/cyclization of <italic>N</italic>-propargylindoles with K₂S₂O₅ aryldiazonium tetrafluoroborates for the construction 2-sulfonyl-substituted 9<italic>H</italic>-pyrrolo[1,2-<italic>a</italic>]indoles is developed.

A novel and convenient visible light-catalyzed tandem radical cyclization of N-propargylindoles with acyl chlorides for accessing 2-acyl-9H-pyrrolo[1,2-a]indoles is established. This transformation involves sequential addition the to carbon-carbon triple bond, intramolecular 2-position indole, isomerization double bond. The experimental results show that this reaction contains a pathway chain process not major formation products.

A highly chemoselective domino condensation/aza-Prins cyclization/retro-aldol between 2-alkenylanilines with β-dicarbonyl compounds under metal-free conditions was accomplished, giving a large category of valuable 2-substituted quinolines in good yields excellent functional group toleration. This newly established process, adopting β-ketoesters as masked C1 synthons via C-C cleavage, could even be simplified into three-component [3 + 2 1] version consisting exceedingly low-priced commercial...

A method for the preparation of 3-alkylated spiro[4.5]trienones via alkylation/ipso-cyclization activated alkynes with 4-alkyl-DHPs under transition-metal-free conditions is proposed. This alkylation successively undergoes generation alkyl radicals, addition radicals to alkynes, and intramolecular ipso-cyclization. The mechanism studies suggest that involves a radical process. ipso-cyclization procedure shows series advantages, such as accessibility, mild conditions, high efficiency, greater...

The photoredox/PPh3-mediated cyclization of 2-isocyanobiaryls has been developed. A substantial range functional-group-rich phenanthridine derivatives were synthesized at room temperature in a highly selective and atom-economic manner. Mechanistic studies suggested that the process is probably mediated both by Ph3P radical cation with key 1,2-hydride transfer hydrogen atom generated through O–H bond homolytic cleavage Ph3P–OH intermediate.

Abstract Enantioselective recognition and separation are the most important issues in fields of chemistry, pharmacy, agrochemical, food science. Here, we developed two optically active diamines showing aggregation‐induced emission (AIE) that can discriminate 5 kinds chiral acids with high enantioselectivity. Especially, a very fluorescence intensity ratio ( I l / d ) 281 for (±)‐Dibenzoyl‐ ‐tartaric acid was obtained through collection change after interaction AIE‐active diamine. By virtue...

Three-dimensional (3D) printed bioactive scaffolds have been widely used in the field of bone tissue engineering. However, its vivo visualization and bacterial inflammation are intractable issues during surgery treatment. Herein, we first synthesized an aggregation-induced emission-active luminogen (AIEgen) named 4BC with efficient reactive oxygen species (ROS) generation. Then, a series 3D loaded were fabricated by precipitation adsorption method, namely 4BC@scaffolds, which showed good...

Thermoregulated phase-transfer iridium nanoparticles exhibited a totally different hydrogenation orientation for α,β-unsaturated aldehydes and ketones.

A metal-free C–H [5 + 1] annulation reaction of 2-arylanilines with diazo compounds has been achieved, giving rise to two types prevalent phenanthridines via highly selective C–C cleavage.

Heterocyclic compounds, especially oxygen-containing heterocyclic are crucial moieties in bioactive compounds and drug leads. Substituted chroman-4-ones a kind of the most significant structural skeletons. Herein, we report visible-light-induced dual acylation alkenes for constructing 3-substituted chroman-4-ones, which undergoes radical tandem cyclization reaction through carbon–carbon bond cleavage oxime esters by nitrogen-centered strategy. A series were prepared with up to 86% yield.

A visible-light-induced four-component reaction of vinylcyclopropanes, N-(acyloxy)phthalimide esters, N,N-dimethylformamide (DMF), and H2O through an oxidative ring opening cyclopropane is presented. This procedure provides a new effective way to construct formate esters. DMF employed as both solvent the source CHO. difunctionalization vinylcyclopropanes shows good functional group tolerance under room temperature. radical pathway involved, carbonyl oxygen ester originated from water in this...