A5100633767- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Ion channel regulation and function
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
- Optimization and Variational Analysis
- Vector-borne infectious diseases
- COVID-19 Clinical Research Studies
- Ion Transport and Channel Regulation
- Plant Virus Research Studies
- HIV Research and Treatment
- interferon and immune responses
- Higher Education Governance and Development
- Biochemical Analysis and Sensing Techniques
- RNA modifications and cancer
- Intracranial Aneurysms: Treatment and Complications
- Higher Education and Teaching Methods
- Geological and Geochemical Analysis
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Contact Mechanics and Variational Inequalities
- Metabolomics and Mass Spectrometry Studies
- Advanced Optimization Algorithms Research
University of Pennsylvania
2019-2024
The University of Texas Medical Branch at Galveston
2023-2024
National Institute for Viral Disease Control and Prevention
2008-2024
Chinese Academy of Sciences
2003-2024
National Institutes for Food and Drug Control
2014-2024
Kunming Institute of Zoology
2007-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Kunming University of Science and Technology
2024
University of South Florida
2013-2023
Shanghai University of Traditional Chinese Medicine
2007-2023
The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages viral replication; the underlying mechanism is currently not known. Here we provide evidence IFITM proteins restrict membrane fusion induced by representatives all three classes proteins. IFITM1 profoundly suppressed syncytia formation and cell-cell almost examined; IFITM2 IFITM3 also strongly inhibited their fusion, with efficiency somewhat dependent...
There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few antivirals, while screening human Huh7.5 validates 23 diverse antiviral Extending our studies lung epithelial cells, find that there are major differences drug sensitivity and entry pathways used by SARS-CoV-2 these cells. Entry Calu-3 pH independent...
The reported prevalence of unruptured cerebral aneurysms (UCAs) varies widely.To measure the UCAs by using 3-dimensional time-of-flight magnetic resonance angiography in adults aged 35 to 75 years.Cross-sectional study done between June 2007 and 2011.Two communities chosen at random from 2 districts (1 urban 1 suburban) Shanghai, China.4813 years.Three-dimensional angiography, interpreted 3 observers blinded participants' information, was used identify location size estimate overall,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic, resulting millions of infections and deaths with few effective interventions available. Here, we demonstrate that SARS-CoV-2 evades interferon (IFN) activation in epithelial cells, delayed response bystander cells. Since pretreatment IFNs can block viral infection, reasoned pharmacological innate immune pathways could control infection. To identify potent antiviral agonists, screened panel 75 microbial...
Japanese encephalitis virus (JEV), a mosquito-borne zoonotic pathogen, is one of the major causes viral worldwide. Previous phylogenetic studies based on envelope protein indicated that there are four genotypes, and surveillance data suggest genotype I gradually replacing III as dominant strain. Here we report an evolutionary analysis 98 full-length genome sequences JEV, including 67 new samples isolated from humans, pigs, mosquitoes, midges. bats in affected areas. To investigate...
Japanese encephalitis (JE) is a global public health issue that has spread widely to more than 20 countries in Asia and extended its geographic range the south Pacific region including Australia. JE become most important cause of viral world. viruses (JEV) are divided into five genotypes, based on nucleotide sequence envelope (E) gene. The Muar strain, isolated from patient Malaya 1952, sole example genotype V JEV. Here, XZ0934 strain JEV was Culex tritaeniorhynchus, collected China....
The interferon-induced transmembrane (IFITM) proteins have been recently shown to restrict HIV-1 and other viruses. Here, we provide evidence that IFITM proteins, particularly IFITM2 IFITM3, specifically antagonize the envelope glycoprotein (Env), thereby inhibiting viral infection. interact with Env in producer cells, leading impaired processing virion incorporation. Notably, level of incorporation into virions does not strictly correlate extent inhibition. Prolonged passage...
Background The current Japanese encephalitis (JE) vaccine derived from G3 JE virus (JEV) can induce protective immunity against G1–G4 JEV genotypes. However, efficacy the emerging G5 genotype has not been reported. Methods/Principal Findings Using in vitro and vivo tests, biological phenotype cross-immunoreactions were compared between (wild strains). PRNT90 method was used to detect neutralizing antibodies different genotypes of vaccine-immunized subjects patients. In mice, lethal challenge...
MicroRNAs (miRNAs) have been recognised to regulate cancer development and progression in carcinogenesis as either oncogenes or tumour suppressor genes. However, whether miR-203 plays a crucial role human laryngeal squamous cell carcinoma (LSCC) remains largely unclear. In the study, we found that expression was significantly lower LSCC tissues than corresponding adjacent non-neoplastic negatively correlated with ASAP1 level. Lower of related poor differentiation, advanced clinical stages,...
Combining chemotherapy and immunotherapy is a promising strategy for the treatment of non-small cell lung cancer (NSCLC) metastasis. However, platinum-based chemotherapeutics immune checkpoint blockade-based have toxic side effects limitations. Ursolic acid (UA) astragaloside IV (AS-IV) are natural compounds with anticancer activity sourced from Traditional Chinese medicine (TCM). their poor water solubilities targeted deletions limit medicinal value. In this study, we fabricated hyaluronic...
Polycomb group proteins protect neurons from injury through a mechanism involving decreased potassium channel function.
Acidosis is a common feature of the human brain during ischemic stroke and known to cause neuronal injury. However, mechanism underlying acidosis-mediated injury remains elusive. We show that decrease in extracellular pH evoked inward currents characteristic acid-sensing ion channels (ASICs) increased intracellular Ca 2+ cultured cortical neurons. Acid-sensing neurons electrophysiological pharmacological properties distinct from those rodent brain. Reverse transcriptase-PCR western blot...
Significance TIM-family proteins have been recently shown to promote viral entry into host cells. Unexpectedly, we discovered that human TIM-1, along with TIM-3 and TIM-4, potently inhibits HIV-1 release. We showed TIM-1 is incorporated virions retains particles on the plasma membrane via phosphatidylserine (PS), a phospholipid exposed cellular envelope. Expression of replication in CD4 + T cells, knockdown monocyte-derived macrophages enhances production. extended this function TIMs other...