A5031935412- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Asymmetric Hydrogenation and Catalysis
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Crystallography and molecular interactions
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
- interferon and immune responses
- Epigenetics and DNA Methylation
- Catalytic C–H Functionalization Methods
- Fatty Acid Research and Health
- Asymmetric Synthesis and Catalysis
- Congenital Heart Disease Studies
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
University of Pennsylvania
2022-2025
Cardiovascular Institute of the South
2025
Penn Center for AIDS Research
2023
University of Delaware
2016
Background The Fontan operation is the current standard of care for single‐ventricle congenital heart disease. Almost all patients with develop liver fibrosis at a young age, known as Fontan‐associated disease (FALD). pathogenesis and mechanisms underlying FALD remain little understood, there are no effective therapies. We aimed to present comprehensive multiomic analysis human FALD, revealing fundamental biology FALD. Methods Results recently generated single‐cell transcriptomic epigenomic...
An enantioselective, copper-catalyzed alkynylation of cyclic α,α-diaryl ketiminium ions has been developed to deliver isoquinoline products with diaryl, tetrasubstituted stereocenters. The success this reaction relied on identification Ph-PyBox as the optimal ligand, i-Pr2NEt base, and CHCl3 solvent. A broad scope functional group tolerance were observed. Notably, use both aryl silyl acetylenes results in high yields enantioselectivities. Mechanistic experiments are consistent a dimeric or...
Background. Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and preserved EF (HFpEF). To develop disease phenotype-specific approaches to define guide treatment, distinguishing biomarkers needed. The goal this study was utilize quantitative metabolomics on a large, diverse population replicate extend existing knowledge the plasma metabolic signatures in human HF. Methods. Quantitative, targeted LC/MS conducted 787 samples collected by...