A5086281128- Single-cell and spatial transcriptomics
- Body Contouring and Surgery
- Facial Rejuvenation and Surgery Techniques
- Gene expression and cancer classification
- Botulinum Toxin and Related Neurological Disorders
- Cell Image Analysis Techniques
- Health, Environment, Cognitive Aging
- Dermatologic Treatments and Research
- Lymphatic System and Diseases
- Molecular Biology Techniques and Applications
- Hair Growth and Disorders
- Reconstructive Surgery and Microvascular Techniques
- Immune cells in cancer
- Bone and Dental Protein Studies
- Psoriasis: Treatment and Pathogenesis
- Myofascial pain diagnosis and treatment
- Renal and Vascular Pathologies
- Biomedical Text Mining and Ontologies
- Machine Learning in Healthcare
- Skin Diseases and Diabetes
- Streptococcal Infections and Treatments
- Medical and Biological Sciences
- IL-33, ST2, and ILC Pathways
- Cancer Genomics and Diagnostics
- Autoimmune Neurological Disorders and Treatments
University of Pennsylvania
2020-2025
Cedars-Sinai Medical Center
2025
California University of Pennsylvania
2020-2024
Northeastern University
2023
Indiana University – Purdue University Indianapolis
2022
Indiana University School of Medicine
2022
Rocky Mountain MS Center
2022
Aesthetic Surgery Center
2021
Ablon Skin Institute and Research Center
2021
UCLouvain Saint-Louis Brussels
2017
Cell populations in the tumor microenvironment (TME), including their abundance, composition, and spatial location, are critical determinants of patient response to therapy. Recent advances transcriptomics (ST) have enabled comprehensive characterization gene expression TME. However, popular ST platforms, such as Visium, only measure low-resolution spots large tissue areas that not covered by any spots, which limits usefulness studying detailed structure Here, we present TESLA, a machine...
ABSTRACT: Although hyaluronic acids are a relatively new treatment for facial lines and wrinkles, they have provided numerous advances in the area of cosmetic surgery. This article discusses inherent properties acid fillers that make them ideal lines. It encompasses review current literature on U.S. Food Drug Administration-approved role each these currently has cosmetics. also potential pitfalls adverse effects can be associated with using filling Finally, it serves as an overview...
Abstract Kidneys possess one of the most intricate three-dimensional cellular structures in body, yet spatial and molecular principles kidney health disease remain inadequately understood. Here, we have generated high-quality datasets for 81 samples, including single cell (sc), nuclear (sn), spot level (Visium) resolution (CosMx) (sp)-RNA expression, sn open chromatin, capturing cells from healthy, diabetic, hypertensive diseased human kidneys. By combining snRNA, snATAC scRNA sequencing...
The human cerebral cortex, pivotal for advanced cognitive functions, is composed of six distinct layers and dozens functionally specialized areas
Spatially resolved transcriptomics (SRT) has advanced our understanding of the spatial patterns gene expression, but lack single-cell resolution in barcoding-based SRT hinders inference specific locations individual cells. To determine distribution cell types SRT, we present SpaDecon, a semi-supervised learning approach that incorporates location, and histology information for cell-type deconvolution. SpaDecon was evaluated through analyses four real datasets using knowledge expected...
Numerous nonsurgical techniques and devices have sought to reproduce the effectiveness of liposuction. Unfortunately, vast majority these has fallen short adequate results or been plagued with complications. UltraShape (UltraShape; Yoqneam, Israel) is a device that able accomplish reduction subcutaneous fat procedure both comfortable leads good patient satisfaction. Its design nonthermal ultrasonic energy produce cavitation leading cell lysis while sparing adjacent blood vessels nerves....
Background. Medium-depth chemical peels are an effective and popular treatment for actinic damage, fine wrinkles, pigmentary dyschromias. However, they also uncomfortable. A previous attempt to study the effectiveness of a topical anesthetic gel in 35% trichloroacetic acid (TCA) peeling found reduction discomfort but increased depth penetration delayed healing. Objective. To evaluate both efficacy two agents medium-depth combination as well histologic result from combined with anesthesia....
COLEMAN, KYLE M. MD; VOIGTS, ROBERT MS; DEVORE, DALE P. PHD; TERMIN, PAUL DVM, WILLIAM III MD Author Information
Abstract Neuroimaging data acquired using multiple scanners or protocols are increasingly available. However, such exhibit technical artifacts across batches which introduce confounding and decrease reproducibility. This is especially true when multi‐batch analyzed complex downstream models more likely to pick up on implicitly incorporate batch‐related information. Previously proposed image harmonization methods have sought remove these batch effects; however, effects remain detectable in...
BACKGROUND SAKURA 3 was a Phase 3, open-label, repeat-dose safety study of DaxibotulinumtoxinA for Injection (DAXI); component the largest clinical development program an aesthetic neuromodulator in glabellar lines. OBJECTIVE To evaluate use DAXI (40U) up to treatments moderate or severe METHODS Eligible subjects rolled over from placebo-controlled trials ( n = 477) were de novo 2,214) and received 1 maximum 84 weeks. Safety efficacy evaluated at least every 4 weeks Week 36 (Treatments 2) 12...
Abstract Recent advances in spatial transcriptomics technologies have enabled comprehensive characterization of gene expression patterns the context tissue microenvironment. To elucidate variation, we present SpaGCN, a graph convolutional network approach that integrates expression, location and histology data analysis. Through convolution, SpaGCN aggregates each spot from its neighboring spots, which enables identification domains with coherent histology. The subsequent domain guided...
Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1α, for the Treatment Psoriasis MABp1is true human monoclonal antibody specific interleukin 1α (IL-1α), key proinflammatory cytokine involved in sterile inflammation that is abundantly present psoriatic skin lesions. 1 MABp1 differs from previous generations therapeutic antibodies it was cloned an Epstein-Barr virus-immortalized B cell isolated individual with endogenous anti-IL-1α antibodies, and has not...
Background. Tumescent anesthesia has revolutionized the practice of liposuction. Inherent to tumescent technique is use large volumes dilute solutions lidocaine with epinephrine instilled into subcutaneous fat deposits. Precise formulation essential liposuction technique. Objectives. To determine actual fluids contained in intravenous (IV) 1 L bags saline used for anesthesia, calculate supplied 50 cc stock 1% lidocaine, and measure amount fluid retained by peristalic pump tubing...
Objective: To evaluate the efficacy and safety of AbobotulinumtoxinA (ABO) dose escalation in correction moderate-to-severe glabellar lines.Design: Phase 2, 36-week, multicenter, randomized, dose-ranging, double-blind, placebo-controlled study.Methods: Adults with lines received a single ABO treatment, dosed at 50, 75, 100, or 125 U, placebo.Primary endpoint was week 4 composite ≥2-grade responder rate among those achieving severity score 0 (none) 1 (mild) maximum frown, evaluated using...
Previous studies indicate that the efficacy and durability of a single AbobotulinumtoxinA (ABO) treatment for moderate to severe glabellar lines may be enhanced with increasing dose, while safety outcomes remain consistent those licensed dose (50 U).Evaluation subject-reported indicators efficacy, satisfaction, psychological well-being ABO escalation.A Phase 2, 36-week, multicenter, randomized, dose-ranging, double-blind, placebo-controlled study was conducted in adults lines. Subjects...