Giulia T. Uhr
A5063419699- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Gastrointestinal motility and disorders
- Viral Infections and Outbreaks Research
- interferon and immune responses
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Dietary Effects on Health
- Probiotics and Fermented Foods
- Fatty Acid Research and Health
University of Pennsylvania
2019-2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic, resulting millions of infections and deaths with few effective interventions available. Here, we demonstrate that SARS-CoV-2 evades interferon (IFN) activation in epithelial cells, delayed response bystander cells. Since pretreatment IFNs can block viral infection, reasoned pharmacological innate immune pathways could control infection. To identify potent antiviral agonists, screened panel 75 microbial...
The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects host physiology and disease. In contrast to the host's genome, microbiome is amenable change over course an organism's lifetime, providing opportunity therapeutically modulate microbiome's impact on human pathophysiology. this Perspective, we highlight environmental factors regulate temporal dynamics microbiome, with a particular focus different time scales at which they act. We propose...
The intestinal epithelium is a key physical interface that integrates dietary and microbial signals to regulate nutrient uptake mucosal immune cell function. transcriptional programs epithelial (IEC) quiescence, proliferation, differentiation have been well characterized. However, how gene expression networks critical for IECs are posttranscriptionally regulated during homeostasis or inflammatory disease remains poorly understood. Herein, we show conserved family of microRNAs, miR-181,...
Summary The intestinal microbiome changes with age, but the causes and consequences of aging remain unclear. Furthermore, gut has been proposed to mediate benefit lifespan- extending interventions such as dietary restriction, this hypothesis warrants further exploration. Here, by analyzing 2997 metagenomes collected longitudinally from 913 deeply phenotyped, genetically diverse mice, we provide new insights into interplay between microbiome, aging, host genetics, a wide range health...