A5030237607- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- dental development and anomalies
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Dietary Effects on Health
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Genetic diversity and population structure
- Fish Ecology and Management Studies
- Gut microbiota and health
- MicroRNA in disease regulation
University of California, Davis
2017-2024
University of Pennsylvania
2019-2023
University of California, Berkeley
2014-2018
The gut microbiota is a key environmental determinant of mammalian metabolism. Regulation white adipose tissue (WAT) by the process critical to maintaining metabolic fitness, and dysbiosis can contribute development obesity insulin resistance (IR). However, how regulates WAT function remains largely unknown. Here, we show that tryptophan-derived metabolites produced controlled expression miR-181 family in adipocytes mice regulate energy expenditure sensitivity. Moreover, dysregulation...
Significance How body pattern evolves in nature remains largely unknown. Although recent progress has been made on the molecular basis of losing morphological features during adaptation to new environments (regressive evolution), there are few well worked out examples how may be gained natural species (constructive evolution). Here we use genetic crosses study threespine stickleback fish have increased their tooth number a freshwater environment. Genetic mapping and gene expression...
Threespine stickleback fish offer a powerful system to dissect the genetic basis of morphological evolution in nature. Marine sticklebacks have repeatedly invaded and adapted numerous freshwater environments throughout Northern hemisphere. In response new diets habitats, changes craniofacial morphology, including heritable increases tooth number, evolved derived populations. Using combination quantitative genetics genome resequencing, here we fine-mapped trait locus (QTL) regulating gain...
The intestinal epithelium is a key physical interface that integrates dietary and microbial signals to regulate nutrient uptake mucosal immune cell function. transcriptional programs epithelial (IEC) quiescence, proliferation, differentiation have been well characterized. However, how gene expression networks critical for IECs are posttranscriptionally regulated during homeostasis or inflammatory disease remains poorly understood. Herein, we show conserved family of microRNAs, miR-181,...
Epidemiologic studies have reported an inverse relationship between childhood Helicobacter pylori infection and development of allergic asthma. Because lung epithelium plays important role in asthma pathogenesis, we hypothesized that H. may directly influence airway epithelial cell innate immune function, particularly early childhood. To test our hypothesis, established vitro model using primary tracheobronchial cultures derived from infant, juvenile adult rhesus monkeys. Airway were...
It is estimated that more than half of the world population has been infected with Helicobacter pylori. Most newly acquired H. pylori infections occur in children before 10 years age. We hypothesized early life infection could influence composition microbiome at mucosal sites distant to stomach. To test this hypothesis, we utilized infant rhesus macaque monkey as an animal model natural colonization determine impact on lung and oral during a window postnatal development. From cohort 4-7...
It is estimated that more than half of the world population has been infected with