A5014328952- Pregnancy and preeclampsia studies
- Neuroscience and Neuropharmacology Research
- Renal Diseases and Glomerulopathies
- Genetics and Neurodevelopmental Disorders
- Wnt/β-catenin signaling in development and cancer
- Ion channel regulation and function
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Cell Adhesion Molecules Research
- Mechanisms of cancer metastasis
- Histone Deacetylase Inhibitors Research
- Connective tissue disorders research
- Maritime Navigation and Safety
- Lipid Membrane Structure and Behavior
- Chronic Kidney Disease and Diabetes
- Crystallization and Solubility Studies
- Protein Degradation and Inhibitors
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Cellular transport and secretion
- Regulation of Appetite and Obesity
- Recommender Systems and Techniques
- Kruppel-like factors research
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Peking University
2018-2022
Second Hospital of Shandong University
2016-2022
Qingdao University
2019
People’s Hospital of Rizhao
2019
Affiliated Hospital of Qingdao University
2019
State Key Laboratory of Natural and Biomimetic Drugs
2018
Metastasis associated lung adenocarcinoma transcript 1(MALAT1) is a long non-coding RNA, broadly expressed in mammalian tissues including kidney and up-regulated variety of cancer cells. To date, its functions podocytes are largely unknown. β-catenin key mediator the canonical non-canonical Wnt signalling pathway; aberrant expression promotes podocyte malfunction albuminuria, contributes to fibrosis. In this study, we found that MALAT1 levels were increased cortices from C57BL/6 mice with...
Accumulating evidence has shown that preeclampsia (PE) was associated with an aberrant maternal-fetal inflammatory response. In the present study, we first found in human PE placentas levels of Toll-like receptor 4 (TLR4), phosphorylated p38 MAPK (p-p38) and cytokines IL-6 MCP-1 were significantly upregulated. Next, demonstrated a notable increase systolic blood pressure (SBP) proteinuria lipopolysaccharide (LPS)-treated pregnant rats; concomitant high TLR4 p-p38 these PE-like rat placentas,...
Fyn, a member of the Src family tyrosine kinases, is key regulator in cytoskeletal remodeling variety cell types. Recent studies have demonstrated that Fyn responsible for nephrin phosphorylation, which will result polymerization actin filaments and podocyte damage. Thus detailed involvement podocytes to be elucidated. In this study, we investigated potential role Fyn/ROCK signaling its interactions with paxillin. Our results presented high glucose led filamentous (F-actin) rearrangement...
Abstract Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its vivo significance diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific inhibition Rac1 was able to attenuate podocyte injury proteinuria by blockade Rac1/PAK1/p38/β-catenin signaling cascade, which reinstated integrity slit diaphragms (SD), rectified effacement...
Preeclampsia is an idiopathic and serious complication during gestation in which placental trophoblast cells differentiate into several functional subtypes, including highly invasive extravillous trophoblasts (EVTs). Although the cause pathogenesis of preeclampsia have remained unclear, numerous studies suggested that inadequacy EVT invasion leads to imperfect uterine spiral artery remodelling, plays a crucial role development preeclampsia. Rac1, or Ras-related C3 botulinum toxin substrate...
Intellectual disability (ID) affects ~2% of the population and ID-associated genes are enriched for epigenetic factors, including those encoding largest family histone lysine acetyltransferases (KAT5-KAT8). Among them is KAT6A , whose mutations cause syndrome, with ID as a common clinical feature. However, underlying molecular mechanism remains unknown. Here, we find that deficiency impairs synaptic structure plasticity in hippocampal CA3, but not CA1 region, resulting memory deficits mice....
Focal adhesion kinase (FAK) is a non-receptor protein tyrosine that regulates cell adhesion, proliferation and differentiation. In the present study, rat model of high fat diet-induced hypercholesterolaemia was established to investigate involvement FAK in lipid disorder-related kidney diseases. We showed focal fusion podocyte foot process occurred at as early 4 weeks rats consuming diet, preceding onset proteinuria when aberrant phosphorylation found. These abnormalities were ameliorated by...
N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated Na+ and Ca2+-permeable ion channels involved in excitatory synaptic transmission plasticity. NMDAR hypofunction has long been implicated the pathophysiology including major depressive disorders (MDDs). Herein, we report a series of furan-2-carboxamide analogues as novel NMDAR-positive allosteric modulators (PAMs). Through structure-based virtual screen electrophysiological tests, FS2921 was identified PAM with potential...
Abstract Inadequate trophoblastic invasion is considered as one of hallmarks preeclampsia (PE), which characterized by newly onset hypertension (>140/90 mmHg) and proteinuria (>300 mg in a 24‐h urine) after 20 weeks gestation. Accumulating evidence has indicated that long noncoding RNAs are aberrantly expressed PE, whereas detailed mechanisms unknown. In the present study, we showed lncRNA Taurine upregulated 1 (TUG1) were downregulated preeclamptic placenta HTR8/SVneo cells under...
ERG3 channels have a high expression level in the central nervous system. Knockdown of enhances neuronal intrinsic excitability (caused by decreased fast afterhyperpolarization, shortened delay time to generation an action potential and enhanced summation somatic excitatory postsynaptic potentials) hippocampal CA1 pyramidal neurons dentate gyrus granule cells. The protein is reduced human mouse epileptogenic foci. hippocampus seizure susceptibility, while mice treated with ERG channel...
The process of placental invasion is essential for a successful pregnancy. Leptin involved in trophoblast invasiveness, and its dysregulation connected with series diseases, including preeclampsia. However, the knowledge precise mechanisms leptin-induced invasiveness still limited. According to present research, transwell assay suggested that leptin dose- time-dependent regulator inducing HTR-8/SVneo cell invasion. Western blot analysis immunofluorescence staining revealed MMP9 expression...
ABSTRACT Intellectual disability (ID) affects ∼2% of the general population and is often genetic in origin. ID-associated genes are enriched for epigenetic factors, including those encoding largest family histone lysine acetyltransferases (KAT5-KAT8). Among them KAT6A , whose de novo heterozygous mutations cause Syndrome (or Arboleda-Tham Syndrome), with ID as a common clinical feature. However, underlying molecular mechanisms remain elusive. Here, we show that haploinsufficiency Kat6a...
Summary Live human brain tissues provide unique opportunities for understanding the physiology and pathophysiology of synaptic transmission. Investigations have been limited to anatomy, electrophysiology, protein localization—while crucial parameters such as vesicle dynamics were not visualized. Here we utilize zap-and-freeze time-resolved electron microscopy overcome this hurdle. First validate approach with acute mouse slices demonstrate that axons parallel electrical field can be...
GLYX-13, a NMDAR glycine-site partial agonist, was discovered as promising antidepressant with rapidly acting effects but no ketamine-like side effects. However, the reported synthetic process route had deficiencies of low yield and use unfriendly reagents. Here, we report scaled-up synthesis GLYX-13 an overall 30% on hectogram scale column chromatography-free strategy, where coupling deprotection reaction conditions were systematically optimized. Meanwhile, absolute configuration precursor...
ByteDance offers several massively popular products such as TikTok, Jinri Toutiao and Douyin for creating, sharing discovering a variety of content, in which recommendation plays an indispensable role helping billions users to interact with highly personalized content. The experience largely comes from the ability sophisticated machine learning models make accurate predictions based on users' interests one key component systems is user profile service.In this paper, we introduce Instance...
Objective To investigate the roles of uPA and TGF-β1 in etiology preeclampsia (PE). Methods The plasma were determined with enzyme linked immunosorbent assay (ELISA) 133 patients PE (74 mild 59 severe PE), compared those normal pregnancy (n=141). Results had lower levels (456.19±37.47) pg/ml than [(676.24±47.16) pg/ml, P<0.01] statistical significance. No significant difference was found between (437.24±47.32) [(478.13±15.89) P>0.05]. higher (16.28±5. 62) ng/ml that [(8.96±3.61)...
Objective To investigate the expression and significance of serum soluble endoglin (sEng) fms-like tyrosine kinase 1 (sFlt-1) in preeclampsia. Methods Serum levels sEng sFlt-1 were determined by enzyme linked immunosorbent assay. Results The level preeclampsia group (6.39±2.15) ng/ml was significantly higher than that control (2.16±0.31) ng/ml, P<0.01, especially early-onset severe (411.11±80.19) pg/ml third trimester (27.57±4.36) pg/ml, but did not correlate with most forms disease....
Objective To investigate the pathogenesis of production anti-neutrophil cytoplasmic antibodies (ANCA) in rat models chronic bronchitis (CB) with recurrent infections. Methods The CB were made by double element smoking and lipopolysaccharide (LPS) stimulation. The rats divided into four groups, including normal control group (n=5), phorbol-12-myristate-13-acetate (PMA)-treated healthy (n=5) PMA-treated (n=6). Renal function was detected. histopathological lung kidney tissues observed...