A5044464771- Medical Imaging and Pathology Studies
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA Research and Splicing
- Curcumin's Biomedical Applications
- Airway Management and Intubation Techniques
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Voice and Speech Disorders
- Head and Neck Cancer Studies
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- RNA Interference and Gene Delivery
- Tracheal and airway disorders
- Kruppel-like factors research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Teratomas and Epidermoid Cysts
- RNA modifications and cancer
- Dysphagia Assessment and Management
- Histone Deacetylase Inhibitors Research
Second Affiliated Hospital of Harbin Medical University
2014-2024
Harbin Medical University
2013-2024
MicroRNAs (miRNAs) have been recognised to regulate cancer development and progression in carcinogenesis as either oncogenes or tumour suppressor genes. However, whether miR-203 plays a crucial role human laryngeal squamous cell carcinoma (LSCC) remains largely unclear. In the study, we found that expression was significantly lower LSCC tissues than corresponding adjacent non-neoplastic negatively correlated with ASAP1 level. Lower of related poor differentiation, advanced clinical stages,...
Tumor-associated macrophages (TAM) induce immunosuppression in laryngeal squamous cell carcinoma (LSCC). The interaction between LSCC cells and TAMs affects the progression of cancer through exosomes, but underlying molecular mechanism remains unclear. Proteomics analysis isolated from human tumor tissues obtained patients with confirmed lymphatic metastasis revealed an upregulation annexin A3 (ANXA3). In TAMs, ANXA3 promoted to polarize M2-like phenotype by activating AKT-GSK3β-β-catenin...
Although surgery is an important treatment for laryngeal cancer, has a significant negative impact on the quality of life patients, and many patients have poor tolerance to surgery. Therefore, alternative chemotherapeutic drugs are research hotspot. Chidamide histone deacetylase inhibitor that selectively inhibits expression type I IIb deacetylases (1, 2, 3 10). It anticancer effect variety solid tumours. This study verified inhibitory chidamide carcinoma. We conducted cellular animal...
<div>Abstract<p>Tumor-associated macrophages (TAM) induce immunosuppression in laryngeal squamous cell carcinoma (LSCC). The interaction between LSCC cells and TAMs affects the progression of cancer through exosomes, but underlying molecular mechanism remains unclear. Proteomics analysis isolated from human tumor tissues obtained patients with confirmed lymphatic metastasis revealed an upregulation annexin A3 (ANXA3). In TAMs, ANXA3 promoted to polarize M2-like phenotype by...
Abstract Dachshund family transcription factor 1 (DACH1) has been shown to exhibit a tumour‐suppressive role in number of human cancers. However, the DACH1 hypopharyngeal squamous cell carcinoma (HPSCC) and its function tumour microenvironment (TME) are still not clear. Crosstalk between cancer cells tumour‐associated macrophages (TAMs) mediates progression HPSCC. The expression DACH1, CD86 CD163 was detected 71 matched HPSCC–non‐cancerous tissue pairs using quantitative real‐time polymerase...
<b><i>Aims:</i></b> To evaluate the patient-to-patient model and swallowing problems in Chinese patients with supraglottic laryngeal cancer (SLC), to find a solution help SLC problems. <b><i>Methods:</i></b> Eighty-nine who had undergone operation for horizontal partial laryngectomy were chosen divided randomly into two groups. The European Organization Research Treatment of Cancer (EORTC), Swallow Quality-of-Life (SWAL-QOL) Visual Analogue...
<p>Figure S1. Proteome profiling in LSCC tissue.</p>
<p>Figure S2. ANXA3 promotes M2-like polarization of macrophages by activating the AKTGSK3β-β-catenin pathway.</p>
<p>Figure S2. ANXA3 promotes M2-like polarization of macrophages by activating the AKTGSK3β-β-catenin pathway.</p>
<p>Figure S5. Mechanism of TAMs-derived-exo-ANXA3 inhibiting ferroptosis in LSCC cells.</p>
<p>Figure S5. Mechanism of TAMs-derived-exo-ANXA3 inhibiting ferroptosis in LSCC cells.</p>
<p>Figure S4. ANXA3 has no effect on ferroptosis in macrophages.</p>
<p>Figure S4. ANXA3 has no effect on ferroptosis in macrophages.</p>
<div>Abstract<p>Tumor-associated macrophages (TAM) induce immunosuppression in laryngeal squamous cell carcinoma (LSCC). The interaction between LSCC cells and TAMs affects the progression of cancer through exosomes, but underlying molecular mechanism remains unclear. Proteomics analysis isolated from human tumor tissues obtained patients with confirmed lymphatic metastasis revealed an upregulation annexin A3 (ANXA3). In TAMs, ANXA3 promoted to polarize M2-like phenotype by...
<p>Figure S1. Proteome profiling in LSCC tissue.</p>
<p>Figure S3. TAMs-derived-exo-ANXA3 inhibits ferroptosis in LSCC cells.</p>
<p>Figure S3. TAMs-derived-exo-ANXA3 inhibits ferroptosis in LSCC cells.</p>
本文报道2例发生于中年男性的单侧喉内型喉气囊肿。例1患者，53岁，因“咽部不适3年，声嘶半个月”入院。例2患者，58岁，因“咽部异物感2年，加重2个月”入院。2例患者术前影像学检查均提示喉部肿物内含气体。入院后全身麻醉下经口硬质支撑弯喉镜辅助的内镜手术（curved laryngoscope assistant transoral surgery，CLATOS，即下咽镜技术）完整切除肿物。术后病理回报均为喉部囊肿，术后随访至今未见肿物复发。.