A5005952869- Medical Imaging and Pathology Studies
- Extracellular vesicles in disease
- Cardiac tumors and thrombi
- Ferroptosis and cancer prognosis
<div>Abstract<p>Tumor-associated macrophages (TAM) induce immunosuppression in laryngeal squamous cell carcinoma (LSCC). The interaction between LSCC cells and TAMs affects the progression of cancer through exosomes, but underlying molecular mechanism remains unclear. Proteomics analysis isolated from human tumor tissues obtained patients with confirmed lymphatic metastasis revealed an upregulation annexin A3 (ANXA3). In TAMs, ANXA3 promoted to polarize M2-like phenotype by...
<p>Figure S1. Proteome profiling in LSCC tissue.</p>
<p>Figure S2. ANXA3 promotes M2-like polarization of macrophages by activating the AKTGSK3β-β-catenin pathway.</p>
<p>Figure S2. ANXA3 promotes M2-like polarization of macrophages by activating the AKTGSK3β-β-catenin pathway.</p>
<p>Figure S5. Mechanism of TAMs-derived-exo-ANXA3 inhibiting ferroptosis in LSCC cells.</p>
<p>Figure S5. Mechanism of TAMs-derived-exo-ANXA3 inhibiting ferroptosis in LSCC cells.</p>
<p>Figure S4. ANXA3 has no effect on ferroptosis in macrophages.</p>
<p>Figure S4. ANXA3 has no effect on ferroptosis in macrophages.</p>
<div>Abstract<p>Tumor-associated macrophages (TAM) induce immunosuppression in laryngeal squamous cell carcinoma (LSCC). The interaction between LSCC cells and TAMs affects the progression of cancer through exosomes, but underlying molecular mechanism remains unclear. Proteomics analysis isolated from human tumor tissues obtained patients with confirmed lymphatic metastasis revealed an upregulation annexin A3 (ANXA3). In TAMs, ANXA3 promoted to polarize M2-like phenotype by...
<p>Figure S1. Proteome profiling in LSCC tissue.</p>
<p>Figure S3. TAMs-derived-exo-ANXA3 inhibits ferroptosis in LSCC cells.</p>
<p>Figure S3. TAMs-derived-exo-ANXA3 inhibits ferroptosis in LSCC cells.</p>