A5100650872- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Wound Healing and Treatments
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Systemic Lupus Erythematosus Research
- Genetic Neurodegenerative Diseases
- 3D Printing in Biomedical Research
- Curcumin's Biomedical Applications
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- RNA Research and Splicing
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- Forensic Entomology and Diptera Studies
- Extremum Seeking Control Systems
- Photonic Crystal and Fiber Optics
- Saffron Plant Research Studies
- Pressure Ulcer Prevention and Management
- Advanced Fiber Optic Sensors
- Natural Fiber Reinforced Composites
- Innovative Microfluidic and Catalytic Techniques Innovation
Chongqing Medical University
2023-2024
Shanghai Jiao Tong University
2023-2024
Second Affiliated Hospital of Jilin University
2019-2022
Shanghai Public Security Bureau
2021
Jilin University
2019-2020
North China University of Technology
2020
Steroid-induced osteonecrosis of the femoral head (SONFH) is a common debilitating orthopedic disease. The bone marrow mesenchymal stem cells (BMSCs) are type which play crucial roles in repair. adipogenic/osteogenic differentiation disorder BMSCs has been widely perceived contributing to SONFH. However, regulatory mechanism still remains unclear. Circular RNA (circRNA), kind stable ncRNA, plays important regulating gene expression via various ways. To date, there no studies uncover circRNA...
Patients with osteoporosis are more likely to suffer prosthesis displacement, subsidence or periprosthesis fracture after replacement. This is due excessive osteoclast activity and a lack of bone marrow mesenchymal stem cell (BMSC) integration at the implant-bone interface locally in setting osteoporosis. In order inhibit local resorption promote integration, we have constructed porous titanium/poloxamer 407 hydrogel system loaded zoledronate (ZOL), bisphosphonate, osteointegration rabbit...
The treatment of tendon/ligament-to-bone injury is a long-standing research challenge in orthopedics and bone tissue engineering. Orderly healing the fibrocartilage layer mineralized crucial for treating tendon-bone interface injuries. We designed three-dimensional printed porous titanium scaffold composite system with thermosensitive collagen hydrogel loaded transforming growth factor β3 (TGF-β3), formulated sustained slow release TGF-β3 at constant rate. In vitro, exhibited good...
Excessive mental workload will reduce work efficiency, but low cause a waste of human resources. It is very significant to study the status operators. The existing classification method based on electroencephalogram (EEG) features, and its accuracy often because channel signals recorded by EEG electrodes are group mixed brain signals, which similar multi-source speech signals. not wise directly analyze in order distinguish feature In this study, we propose independent components (ICs)...
Breast reconstruction is highly recommended for patients subjected to breast surgery considering its impact on mental health. Current approaches include autologous-based tissue flaps, autologous fat grafting and artificial implants, which may cause severe adverse effects, including deformity morbidity. Recently, engineering methods integrating various biomaterials diverse stem cells the purpose of regenrating structures have been vastly explored. Nonetheless, regenerating refined...
Osteoporosis is an age-related metabolic disease that results in limited bone regeneration capacity and excessive osteoclast activity. After arthroplasty patients with osteoporosis, poor interface osseointegration resulting from insufficient ability often leads to catastrophic complications such as prosthesis displacement loosening periprosthetic fractures. In this study, we prepared a thermosensitive hydrogel loaded morphogenetic protein-2 (BMP-2) promote osteogenesis osteoprotegerin (OPG)...
Osteoporosis-derived bone marrow mesenchymal stem cells (OP-BMSCs) have impaired cell function, low osteogenic activity, and potential osteoclast inducibility, resulting in insufficient osseointegration increased risk of catastrophic postoperative complications after arthroplasty. The autophagy activity OP-BMSCs contributed to poor osseointegration, which could be regulated by the classical autophagic activator, rapamycin. Hence, it is great significance regulate rapamycin promote at...
Abstract Background Type 2 diabetes mellitus (T2DM) is closely linked to metabolic syndrome, characterised by insulin resistance, hyperglycaemia, abnormal lipid metabolism, and chronic inflammation. Diabetic ulcers (DUs) comprise consequential complications that arise as a result of T2DM. To investigate, db/db mice were used for the disease model. The findings demonstrated scaffold made from combination rhubarb charcoal-crosslinked chitosan silk fibroin, designated RCS/SF, was able improve...
Osteoarthritis (OA) is a common cause of morbidity and disability worldwide. However, the pathogenesis OA unclear. Therefore, this study was conducted to characterize implicated genes OA. The gene expression profiles GSE82107 GSE55235 were downloaded from Gene Expression Omnibus database. Altogether, 173 differentially expressed including 68 upregulated 105 downregulated in patients with selected based on criteria <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
MicroRNAs (miRNAs) play essential functions in pathogenesis of Ewing sarcoma (ES). However, the molecular mechanisms responsible for ES occurrence and development through regulation miRNAs remain largely unknown. This study is aimed to explore differential expressed mRNAs that vital roles ES. GSE80201 miRNA GSE68776 mRNA microarray dataset were selected carry out a series bioinformatics analysis such as GEO 2R, gene ontology, pathway enrichment analysis, Venn PPI network construction predict...
Abstract Objectives: Rheumatoid arthritis (RA) is the most common inflammatory in world, but its underlying mechanism still unclear. The present study aims to screen and verify potential biomarkers of RA. Methods: We searched Gene Expression Omnibus (GEO) database for synovial expression profiling from different RA microarray studies perform a systematic analysis. Functional annotation differentially expressed genes (DEGs) was conducted, including GO enrichment analysis Kyoto Encyclopedia...
We experimentally demonstrated self-compression of near-200-fs Yb:KGW laser to 7 fs at 100 kHz in a single gas-filled anti-resonant hollow-core photonic crystal fiber.
Abstract Photobromination reaction of oxime ether (OE) to brominated (BOE) is an important process for the synthesis trifloxystrobin in fungicide industry. Herein, continuous BOE photomicroreactors was performed. Initially, investigation carried out study effects various parameters, including mixing performance, molar ratios, solvents, incident photon flux, and temperature, on photobromination process. Moreover, a kinetic model established, activation energies main side reactions were...