A5054305626- Innovative Microfluidic and Catalytic Techniques Innovation
- HIV/AIDS drug development and treatment
- Microfluidic and Capillary Electrophoresis Applications
- Catalytic Processes in Materials Science
- Advanced Photocatalysis Techniques
- Electrochemical Analysis and Applications
- Analytical Chemistry and Chromatography
- TiO2 Photocatalysis and Solar Cells
- Chemistry and Chemical Engineering
- Oxidative Organic Chemistry Reactions
- Protein purification and stability
- Asymmetric Hydrogenation and Catalysis
Shanghai Jiao Tong University
2022-2024
Recent advancements in light-emitting diode (LED) technology and photomicroreactors have provided a prudent roadmap for scaling-up the photooxidation processes. In this work, we presented highly efficient, chromoselective, wavelength-selective high-power LED-based photomicroreactor (HLPMR) multikilogram ascaridole production through solvent-free α-terpinene photooxidation. First, segregated kinetically controlled mass transfer limited zones by implementing various operating schemes....
Abstract Multi‐step reaction processes are frequently encountered in the synthesis of pharmaceuticals, separate study on each step however is easily neglected. Herein, we separately investigated two steps for an intermediate (DTG‐6) anti‐HIV drug dolutegravir (DTG) microreactors. The first (i.e., deprotection DTG‐4) was optimized to achieve a high DTG‐5 yield 96.7%) microreactor after parametric screening DTG‐4 concentration, methanesulfonic acid loading, molar ratio components, and so...
In the existing two-step method for preparation of DTG-6 (i.e., an important intermediate anti-HIV drug Dolutegravir (DTG)), a strong base is required to neutralize homogeneous acid catalyst first step make reaction solution weakly acidic DTG-5 cyclization in second step. The yield synthesis affected by with carboxyl group on generated DTG-5. this article, solid catalyst, titanium cation-exchanged montmorillonite (Ti4+-mont), was used microfluidized bed catalyze conversion DTG-4 can be...
Abstract Photobromination reaction of oxime ether (OE) to brominated (BOE) is an important process for the synthesis trifloxystrobin in fungicide industry. Herein, continuous BOE photomicroreactors was performed. Initially, investigation carried out study effects various parameters, including mixing performance, molar ratios, solvents, incident photon flux, and temperature, on photobromination process. Moreover, a kinetic model established, activation energies main side reactions were...