A5100446471- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition and Health in Aging
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Intellectual Capital and Performance Analysis
- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Plant Disease Resistance and Genetics
- Cancer Cells and Metastasis
- Oxidative Organic Chemistry Reactions
- Genomics and Rare Diseases
- Biofield Effects and Biophysics
- Medicinal Plants and Bioactive Compounds
Fudan University
2025
First Affiliated Hospital of Xiamen University
2014-2025
Central South University
2025
Shanghai Jiao Tong University
2024
Huizhou Central People's Hospital
2024
Guangdong Medical College
2024
Fujian Medical University
2019-2024
Education Department of Fujian Province
2024
Zhejiang University
2024
Changchun University of Chinese Medicine
2022-2023
Importance Gastric and gastroesophageal junction cancers are diagnosed in more than 1 million people worldwide annually, few effective treatments available. Sintilimab, a recombinant human IgG4 monoclonal antibody that binds to programmed cell death (PD-1), combination with chemotherapy, has demonstrated promising efficacy. Objective To compare overall survival of patients unresectable locally advanced or metastatic gastric who were treated sintilimab chemotherapy vs placebo chemotherapy....
Esophageal squamous cell carcinoma (ESCC) ranks fourth among cancer-related deaths in China due to the lack of actionable molecules. We performed whole-exome and T-cell receptor (TCR) repertoire sequencing on multi-regional tumors, normal tissues blood samples from 39 ESCC patients. The data revealed 12.8% ERBB4 mutations at patient level functional study supported its oncogenic role. 18% patients with early BRCA1/2 variants were associated high-level contribution signature 3, which was...
Abstract Background Human ovarian cancer specific transcript 2 (HOST2) is a long non-coding RNA (lncRNA) reported to be specifically high expressed in human cancer. However, the mechanism that how HOST2 regulates triple negative breast (TNBC) need explored. Methods In this study, expression of was determined 40 TNBC patients and matched non-cancerous tissues by qRT-PCR situ hybridization (ISH) assay. The biological functions measured losing features. effect on viability, proliferation...
Esophageal carcinoma (EsC) is a clinically challenging neoplastic disease. Genistein, natural isoflavone product, has anti-tumor properties. Through in vitro and vivo studies, we found that genistein suppressed EsC cell proliferation time- concentration-dependent manner. In addition, markedly promoted apoptosis arrested cycle at the G0/G1 phase Furthermore, high concentrations of have no adverse effect on normal esophageal epithelial cells. Mechanistically, treatment strikingly reduced...
Abstract Background: The phase III ORIENT-16 trial evaluated sin (a PD-1 inhibitor) versus placebo plus chemo as first-line (1L) treatment in pts with advanced G/GEJ adenocarcinoma. Sin+chemo previously showed a significant improvement OS vs PD-L1 combined positive score (CPS) ≥5 (HR 0.660; 95% CI 0.505-0.864; P=0.0023) and all 0.766; 0.626-0.936; P=0.0090), median follow-up of 18.8 months (m) at interim analysis (Xu, et al. Ann Oncol 2021). Here we report the results from final...
4046 Background: Adding a claudin18.2 antibody to chemotherapy is clinically validated approach for patients with high CLDN18.2 expressing tumors. TST001 best in class differentiated whose improved affinity and enhanced antibody-dependent cellular cytotoxicity, leads anti-tumor activity low medium expressors gastric cancer cells. Pre-clinical studies also showed that has stronger tumor regression effects than the IMAB362-analog at same dose. Methods: The efficacy safety of osemitamab CAPOX...
Abstract Cancer immunotherapy offers significant clinical benefits for patients with advanced or metastatic tumors. However, immunotherapeutic efficacy is often hindered by the tumor microenvironment's high redox levels, leading to variable patient outcomes. Herein, a therapeutic liposomal gold nanocage (MGL) innovatively developed based on photo‐triggered hyperthermia and releasable strategy combining glutathione (GSH) depletion remodel immune microenvironment, fostering more robust...
This paper investigates the role of market makers in an order-driven market, focusing on maker mechanism introduced China's Sci-Tech Innovation Board (STAR Market) October 2022. Using a Difference-in-Differences (DiD) framework, we analyze stock liquidity changes before and after implementation making. Our findings reveal that significantly improve by reducing spreads, with effect being particularly pronounced stocks characterized high price jump probabilities low trading volumes. Examples...
The circadian rhythm is a phenomenon in which physiological, behavioral, and biochemical processes within an organism naturally fluctuate over period of approximately 24 hours. This ubiquitous living organisms. Disruption rhythms mammals leads to different diseases, such as cancer, neurodegenerative metabolic disorders. In specific tissues, numerous genes have been found oscillations, suggesting broad role for the regulation gene expression. review systematically summarizes cryptochromes...
This passage talks about the formation of breast cancer and traditional treatment curing cancer. Breast is one most common cancers all over world. There are many people died because this Now, doctors have several methods to cure cancer, two radiation therapy surgery. Although these can they disadvantages scientists try find new ways With invention technology, invented nanoparticle drug delivery system tried use systems treat Nanoparticle also different limitations in The three main ways:...
Abstract Emerging evidences suggest that long noncoding RNA (lncRNA) plays a vital role in tumorigenesis and cancer progression. Here, the aim of this study is to investigate biological function intervening Linc00284 colorectal (CRC). The expression levels Linc00284, miR-27a c-Met were evaluated by qPCR and/or Western blotting. Immunohistochemistry was used detect Ki67 Phh3 tumor tissues. interaction between validated luciferase reporter assay immunoprecipitation (RIP) assay. Cell...
To evaluate pembrolizumab in patients of Chinese descent with microsatellite instability-high (MSI-H)/deficient mismatch repair (dMMR) tumors enrolled KEYNOTE-158 (Cohort L).
Abstract Background The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) gastric (GC) with deficiency mismatch repair (dMMR) or microsatellite instability-high (MSI-H). Methods This retrospective study enrolled patients dMMR/MSI-H CRC GC who received at least one dose ICIs (neoadjuvant cohort, NAC) (adjuvant AC) 17 centers China. Patients stage IV disease were also eligible if all tumor lesions...
Purpose: Using the gastric cancer cell line SGC7901 and stem (CSC-G), we conducted this study to investigate role of cells in invasion, metastasis tumor angiogenesis.Methods: Stem markers (OCT4, SOX2, C-Myc Klf4) expression was detected by RT-PCR Western blotting.The proliferation, migration, invasion abilities, L-OHP 5-FU resistance, angiogenesis were assessed using vitro spherical clone formation assays, plate cloning experiments, transwell drug scratch-wound ring assay, their tumorigenic...
Breast carcinoma (BRCA) is the most common among women worldwide. Despite great progress achieved in early detection and treatment, morbidity mortality rates remain high. In present study, we make a systematic analysis of BRCA using TCGA database by applying CIBERSORT ESTIMATE computational methods, uncovered CD3D as prognostic biomarker intersection univariate COX protein-protein interaction (PPI). It revealed that high expression was strongly associated with poor survival BRCA, based on...
Lung cancer with highest morbidity and mortality seriously threatens human health worldwide. Long noncoding RNAs (lncRNAs) exert important biological functions by acting as microRNA, which is implicated in tumorigenesis development. Previous work has reported that lncRNA-ATB expression was significantly upregulated lung adenocarcinoma tissues promoted tumor progression; however, the mechanisms of squamous carcinoma (LSC) are still fairly elusive. In our study, also markedly increases LSC...
Background: Chemotherapy combined with antivascular endothelial growth factor (VEGF) or anti-epidermal receptor monoclonal antibodies is the most promising approach to prolong survival and improve quality of life patients unresectable metastatic colorectal cancer (mCRC). Anlotinib an oral antiangiogenic tyrosine kinase inhibitor that targets VEGF receptors 1/2/3, fibroblast 1-4, platelet-derived a/β. Since anlotinib oxaliplatin capecitabine (CAPEOX) as a first-line treatment was previously...
Liver metastasis remains the leading cause of cancer-related mortality in colorectal cancer. The mechanism occurrence and development liver from cancer is unclear.The primary tumor tissues blood samples 8 patients with were collected, followed by nucleic acid extraction library construction. Whole-exome sequencing was performed to detect genomic variations. Bioinformatics used comprehensively analyze data these samples, including differences mutation burden, characteristics gene mutations,...
Background: In microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers, the optimum therapy after progression of immune checkpoint inhibitors (ICIs) is yet unknown. Here, we compared efficacy programmed death 1 (PD1)/programmed ligand-1 (PD-L1) plus other and chemotherapy with or without targeted in MSI/dMMR cancer patients on anti-PD1/PD-L1 monotherapy. Methods: We retrospectively recruited who had progressed Objective response rate (ORR), disease control...