A5101869357- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Mechanical Circulatory Support Devices
- Cardiovascular and Diving-Related Complications
- Osteoarthritis Treatment and Mechanisms
- Aortic Disease and Treatment Approaches
- Cancer Immunotherapy and Biomarkers
- Bone and Joint Diseases
- Polysaccharides and Plant Cell Walls
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Trauma Management and Diagnosis
- Surgical Sutures and Adhesives
- Colorectal Cancer Treatments and Studies
- Polysaccharides Composition and Applications
- Cardiovascular Issues in Pregnancy
Tianjin Medical University General Hospital
2022-2025
Xinjiang Medical University
2015-2025
Tumor Hospital of Xinjiang Medical University
2015-2025
Nanjing University of Chinese Medicine
2015-2024
Tianjin Medical University
2022-2024
First Affiliated Hospital of Xiamen University
2024
Capital Medical University
2008-2020
Beijing Anzhen Hospital
2009-2020
Capital University
2017
Triazole demonstrates distinctive physicochemical properties, characterized by weak basicity, various dipole moments, and significant dual hydrogen bond acceptor donor capabilities. These features are poised to play a pivotal role in drug–target interactions. The inherent polarity of triazole contributes its lower logP, suggesting the potential improvement water solubility. metabolic stability adds additional value drug discovery. Moreover, metal-binding capacity nitrogen atom lone pair...
Oxidative stress is closely associated with the initiation and progression of aging. Considerable interest centers in potential application natural polysaccharides oxidative alleviation senescence delay. Herein, LFP-05S, an acidic heteropolysaccharide from Lycii fructus, was purified structurally characterized based on a combination strategy molecular weight (MW) distribution, monosaccharide composition, methylation NMR spectroscopy analysis. The dominant population LFP-05S composed long...
Objective Glucocorticoid (GC) overuse is strongly associated with steroid‐induced osteonecrosis of the femoral head (SINFH). However, underlying mechanism SINFH remains unclear. This study aims to investigate effect dexamethasone (Dex)‐induced oxidative stress on osteocyte apoptosis and mechanisms. Methods Ten patients 10 developmental dysplasia hips (DDH) were enrolled in our study. Sixty rats randomly assigned Control, Dex, Dex + N‐Acetyl‐L‐cysteine (NAC), Dibenziodolium chloride (DPI),...
Gastric cancer (GC) poses a substantial risk to human health due its high prevalence and mortality rates. Nevertheless, current therapeutic strategies remain insufficient. Single-cell RNA sequencing (scRNA-seq) offers the potential provide comprehensive insights into GC pathogenesis. To explore distribution dynamic changes of cell populations in tumor microenvironment using scRNA-seq techniques. Cancerous tissues paracancerous were obtained from patients diagnosed with at various stages (I,...
In recent years, researchers have examined the use of polyunsaturated fatty acids (PUFA) or a low omega-6/3 ratio to protect knee joint. The current study is based on genome-wide association (GWAS) analysis and uses Mendelian randomization (MR) method evaluate effect total PUFA, omega-3, omega-6, ratios osteoarthritis (OA). First, we downloaded latest PUFA OA GWAS data. data were divided into four groups: ratios. split nine hip (total, males, females), hand females). Then, qualified SNPs...
Resistance to chemotherapy is a major challenge in the effective treatment of patients with gastric cancer; however, mechanisms underlying chemoresistance cancer cells are yet be elucidated. MicroRNAs (miRNAs) have previously been associated progression and sensitivity chemotherapy; therefore, present study aimed identify miRNAs that may influence human cisplatin (DDP) treatment. Initially, were differentially expressed between DDP-sensitive SGC7901 cell line DDP-resistant SGC7901/DDP...
Objective: The aim of this study was to compare, in patients with permanent atrial fibrillation (AF), the efficacy and safety left ablation that a biatrial procedure assess risk factors for late failure sinus rhythm restoration. Methods: Between January 2004 2007, 299 consecutive underwent radiofrequency AF associated concomitant cardiac surgery. According prospective, open, randomized trial, 149 plus cavotricuspid isthmus (left group), while 150 (biatrial group). postoperative mid-term...
Minimally invasive pulmonary vein isolation was developed as a treatment of lone atrial fibrillation. Until recently, electrophysiological studies in patients with recurrent arrhythmias had not been described.One hundred thirty underwent mini-maze isolation. We performed catheter ablation guided by CARTO mapping 8 (mean 61.8 + or - 12.7 years old; male:female ratio, 5:3) 5.0 14 months after the original surgical procedure.Recurrent fibrillation occurred 4 patients, tachycardia 1 patient, and...
Evidence has shown that hypoxia promotes esophageal squamous cell carcinoma (ESCC) growth and metastasis, but the molecular mechanisms underlying response remain poorly understood. MicroRNAs (miRNAs) are post-transcriptional regulators participate in various cancer-related processes. Here, we demonstrated along with hypoxia-inducible factor 1α significantly increased expression of miR-10b-3p. Inhibition miR-10b-3p weakened effects on ESCC proliferation, migration invasion, while...
Scavenging of oxidative stress by antioxidants may provide a therapeutic strategy for nonalcoholic fatty liver disease (NAFLD). Increasing evidence is supporting the potential application natural resourced polysaccharides as promising prevention or treatment strategies against NAFLD. In current study, an acidic heteropolysaccharide, LFP‐a1, was isolated and purified from Lycii fructus with successively hot water refluxing extraction, alcohol precipitation, protein removal, DEAE‐52 cellulose...
Abstract Background The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) gastric (GC) with deficiency mismatch repair (dMMR) or microsatellite instability-high (MSI-H). Methods This retrospective study enrolled patients dMMR/MSI-H CRC GC who received at least one dose ICIs (neoadjuvant cohort, NAC) (adjuvant AC) 17 centers China. Patients stage IV disease were also eligible if all tumor lesions...
Background Ganglionated plexi (GP) ablation has been become an adjunct to pulmonary vein isolation (PVI). This study describes the long-term results of minimally invasive surgical PVI, GPs, and exclusion left atrial appendage for fibrillation (AF). Methods Long-term follow-up 55 months was performed in 139 consecutive patients (age 58.3±20.8 years) with symptomatic, drug-refractory lone AF who underwent GPs ablation, appendage. Success defined as freedom from AF, flutter, or tachycardia off...
This study aimed to identify the hub genes and pathways of related oxidative stress cartilage in osteonecrosis femoral head (ONFH), predict transcription factors genes.The GSE74089 was obtained from Gene Expression Omnibus (GEO) database, including 4 necrotic tissues normal tissues, differentially expressed (DEGs) were identified by limma package R language. Simultaneously, we searched for Ontology (GO) database. GO signaling analysis performed using DAVID, Metascape, GSEA. Protein-protein...
This study assessed the role of surgical ablation for atrial fibrillation (AF) in decreasing tricuspid regurgitation (TR) and right-sided heart remodeling patients after mitral valve procedure.
Objective To assess the efficacy of video-assisted minimally invasive surgical vs. catheter ablation for long-standing persistent AF. Methods We performed a retrospective comparative analysis in series 166 AF patients treated between 2006 and 2009 with either (83 patients), or ablations patients). The group was screened using ‘pair-matched case-control’ methodology order to select appropriate statistical comparison candidates out 169 which were potentially suitable surgery, but have been...