A5100436020- Heat shock proteins research
- Computational Drug Discovery Methods
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- ATP Synthase and ATPases Research
- Bioactive Natural Diterpenoids Research
- Toxin Mechanisms and Immunotoxins
- Ubiquitin and proteasome pathways
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Protein Structure and Dynamics
- Click Chemistry and Applications
- Plant biochemistry and biosynthesis
- Glutathione Transferases and Polymorphisms
- Protein Degradation and Inhibitors
- Phytochemistry and Biological Activities
- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- DNA Repair Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Protein Tyrosine Phosphatases
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
State Key Laboratory of Natural Medicine
2016-2025
China Pharmaceutical University
2016-2025
Fudan University
2025
Hebei North University
2023-2024
University of Connecticut
2024
Wuhan University
2022-2024
Changhai Hospital
2017-2024
Renmin Hospital of Wuhan University
2022-2024
Zhongyuan University of Technology
2023-2024
Binzhou University
2015-2024
Triazole demonstrates distinctive physicochemical properties, characterized by weak basicity, various dipole moments, and significant dual hydrogen bond acceptor donor capabilities. These features are poised to play a pivotal role in drug–target interactions. The inherent polarity of triazole contributes its lower logP, suggesting the potential improvement water solubility. metabolic stability adds additional value drug discovery. Moreover, metal-binding capacity nitrogen atom lone pair...
Tumor necrosis factor alpha (TNFalpha) has been used to treat certain tumors in clinic trials. However, the curative effect of TNFalpha undermined by induced-NF-kappaB activation many types tumor. Maslinic acid (MA), a pharmacological safe natural product, known for its important effects as anti-oxidant, anti-inflammatory, and anti-viral activities. The aim this study was determine whether MA potentiates anti-tumor activity though regulation NF-kappaB activation.In study, we demonstrate that...
// Chao Zhang 1, 2 , Hui-Jie Wang Qi-Chao Bao Lei Tian-Kun Guo Wei-Lin Chen Li-Li Xu Hai-Shan Zhou Jin-Lei Bian Ying-Rui Yang Hao-Peng Sun 2, 3 Xiao-Li Qi-Dong You 1 Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, State Natural Medicines, Department Medicinal Chemistry, School Pharmacy, Correspondence to: Xu, email: xuxiao_li@126.com You, youqidong@gmail.com Keywords: NRF2, breast cancer, RhoA/ROCK pathway, cell proliferation,...
Directly disrupting the Hsp90-Cdc37 complex can selectively down-regulate kinase clients of Hsp90 and achieve cell cycle arrest.
A normal phosphorylation state is essential for the function of proteins. Biased regulation frequently results in morbidity, especially hyperphosphorylation oncoproteins. The ASK1 at Thr838 leads to a persistently high activity state, which accelerates course gastric cancer. Under conditions, PP5 specifically dephosphorylates p-ASK1T838 cells, thereby weakening low-basal state. However, tumor types, shows low with self-inhibition mechanism, making remain level. Thus, we aim design...
Herein, we report a series of selective sub-nanomolar inhibitors against butyrylcholinesterase (BChE). These compounds, bearing novel N-benzyl benzamide scaffold, inhibited BChE with IC50 from picomolar to nanomolar. The inhibitory activity was confirmed by the surface plasmon resonance assay, showing KD value, which revealed that compounds exert effect through directly binding BChE. Several showed neuroprotective effects verified oxidative damage model. Furthermore, safety S11-1014 and...
Butyrylcholinesterase (BChE) is a promising biomarker and effective therapeutic target for Alzheimer's disease (AD). Herein, we designed BChE-activated near-infrared (NIR) probe,
Introduction The 90-kDa heat shock protein (HSP90) functions as a molecular chaperone, it assumes significant role in diseases such cancer, inflammation, neurodegeneration, and infection. Therefore, the research development of HSP90 inhibitors have garnered considerable attention.