A5001929418- Heat shock proteins research
- Metal-Organic Frameworks: Synthesis and Applications
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Computational Drug Discovery Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Toxin Mechanisms and Immunotoxins
- Lanthanide and Transition Metal Complexes
- Protein Degradation and Inhibitors
- Soil Carbon and Nitrogen Dynamics
- Autophagy in Disease and Therapy
- Zebrafish Biomedical Research Applications
- Crystallography and molecular interactions
- interferon and immune responses
- Plant nutrient uptake and metabolism
- Inorganic and Organometallic Chemistry
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Synthesis of Organic Compounds
- Cell death mechanisms and regulation
- Soil and Water Nutrient Dynamics
- Nonlinear Optical Materials Research
- Immune cells in cancer
- Peptidase Inhibition and Analysis
Stanford University
2025
South China Botanical Garden
2020-2024
Chinese Academy of Sciences
2020-2024
Central South University
2012-2024
University of Chinese Academy of Sciences
2023
Second Xiangya Hospital of Central South University
2022
Anhui University
2022
Qilu Hospital of Shandong University
2021
Jinggangshan University
2019-2020
China Pharmaceutical University
2014-2019
Abstract Forest productivity usually declines with the increase in age of stand, which may be associated disturbance balance nitrogen (N) and phosphorus (P) nutrients. However, effects stand on plantation nutrient is still unclear. Therefore, an experiment was conducted this study to investigate influence (6‐, 10‐, 15‐, 25‐, 30‐, 34‐year‐old stands) plant growth dynamics N P Castanopsis hystrix plantations Southern China. The reduced leaf N:P. Moreover, found positively correlated N:P,...
As the endoplasmic reticulum paralogue of Hsp90, Grp94 chaperones a small set client proteins associated with some diseases, including cancer, primary open-angle glaucoma, and inflammatory disorders. Grp94-selective inhibition has been potential therapeutic strategy for these diseases. In this study, inspired by conclusion that ligand-induced "Phe199 shift" effect is structural basis inhibition, series novel selective inhibitors incorporating "benzamide" moiety were developed, among which...
Molecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase, thereby inducing degradation. Glutarimide-containing compounds MGDs bind cereblon (CRBN) recruit neosubstrates. Through explorative synthesis of glutarimide-based library, we discovered series induce casein kinase 1 alpha (CK1α) By scaffold hopping rational modification the chemical scaffold, identified imidazo[1,2-a]pyrimidine compound induces potent selective...
Necrostatin-1 (Nec-1) inhibits necroptosis and is usually regarded as having no effect on other cell deaths. Here, this study explored whether the addition of Nec-1 has an death induced by simulated ischemia injury in rat tubular line NRK-52E. In addition, we also investigated mechanism attenuates renal model. The NRK-52E cells were incubated with TNF-α + antimycinA (TA) for 24 h or without Nec-1. Cell was observed under fluorescent microscope quantified flow cytometry. viabilities detected...
Acute kidney injury (AKI) induced by renal ischemia is a common clinical problem associated with high morbidity and mortality. The present study investigated whether necroptosis was in an vitro model the addition of necrostatin-1 (Nec-1) has protective effect. In addition, autophagy inhibited following use Nec-1 also examined. When apoptosis z-VAD‑fmk energy depleted antimycin A for 1 h, morphological abnormalities human proximal tubular epithelial (HK-2) cells were markedly attenuated, cell...
Heat shock protein 90 (Hsp90) is a potential target for oncology therapeutics. Some inhibitors have shown antitumor effects in clinical trials, spurring the discovery of small molecule Hsp90 inhibitors. Here, we describe structural optimization studies hit compound, tetrahydropyrido[4,3-d]pyrimidine-based inhibitor 15, which exhibits inhibitory activity against Hsp90. A series analogues were synthesized, and their structure-activity structure-property relationships analyzed. These...
In order to explore the key residues of Hsp90–Cdc37 binding interface for further design peptide inhibitors, a combined strategy molecular dynamics simulation and MM-PBSA analysis was performed.
Abstract Pulmonary arterial hypertension (PAH) featured a debilitating progressive disorder. Here, we intend to determine diagnosis‐valuable biomarkers for PAH and decode the fundamental mechanisms of biological function these markers. Two mRNA microarray profiles (GSE70456 GSE117261) two microRNA (GSE55427 GSE67597) were mined from Gene Expression Omnibus platform. Then, identified differentially expressed genes (DEGs) miRNAs (DEMs), respectively. Besides, investigated online miRNA...
The effectiveness of bifunctional alkylating nitrogen mustard compounds in chemotherapy is related to their ability form DNA inter-strand crosslinks. Patients exposed crosslinking (ICL) agents subsequently experience an elevated incidence myelodysplastic syndromes (MDS) and MDS acute myeloid leukemia. Fanconi's anemia (FA) patients are deficient the repair crosslink damage they a high MDS. These observations indicate that hematopoietic cells specific target for transforming effects damage....
CDC37 has emerged as a promising target in antitumor chemotherapy because of its significant role oncogenic signaling networks.
Molecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase thereby inducing degradation. Glutarimide-containing compounds MGDs bind to cereblon (CRBN) recruit neosubstrates. Through explorative synthesis of glutarimide-based library, we discovered series induce casein kinase 1 alpha (CK1α) By scaffold hopping rational modification the chemical scaffold, identified imidazo[1,2-a]pyrimidine compound induces potent selective...
Reforming medical insurance payment methods is a key part of deepening the healthcare system reform. Understanding influencing factors and underlying mechanisms physicians' strategic behaviors under diagnosis-related groups (DRG) crucial for reducing resource waste improving efficiency health fund utilization. Based on Theory Planned Behavior, this study used grounded theory to construct questionnaire encompassing belief, behavioral attitude, subjective norm, perceived control, intention,...
Aims Forest productivity may decrease with increasing stand age, which be related to a shift in the nitrogen (N) and phosphorus (P) nutrient balance. However, it is unclear how plantation balance changes age affects productivity. Methods We experimented ages (6-, 10-, 15-, 25-, 30-, 34-year-old stands) Castanopsis hystrix plantations southern China. Plant growth carbon (C), N, P dynamics were assessed at ecosystem level (leaf–litter–soil–microorganism). Results Increasing reduced leaf N:P...
Bladder cancer is one of the most common urothelial tumors with high incidence and mortality rates. Although it has been reported that microRNA (miR)-133b can regulate tumorigenesis bladder cancer, mechanism remains unclear. Sex-determining region Y-box transcription factor 4 (SOX4) exhibits an important role in tumorigenesis, but unclear whether SOX4 miR-133b are associated regulation pathogenesis cancer. This study aims to determine expressions tissues cells, investigate their effects on...