A5100394278- Surfactants and Colloidal Systems
- Analytical Chemistry and Chromatography
- Advancements in Transdermal Drug Delivery
- Organoselenium and organotellurium chemistry
- Lipid Membrane Structure and Behavior
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Mass Spectrometry Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Environmental Chemistry and Analysis
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Electrostatics and Colloid Interactions
- Synthesis and Biological Evaluation
- Chemical Reactions and Isotopes
- Forensic Toxicology and Drug Analysis
- Catalytic Cross-Coupling Reactions
- Microwave-Assisted Synthesis and Applications
- Hormonal and reproductive studies
- Analytical Methods in Pharmaceuticals
- Synthesis and Catalytic Reactions
- Photochemistry and Electron Transfer Studies
- Advanced Drug Delivery Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Pesticide Residue Analysis and Safety
Shenyang Pharmaceutical University
2019-2024
Nanjing University of Chinese Medicine
2024
China University of Geosciences (Beijing)
2022-2024
Rutherford Appleton Laboratory
2019-2024
Beijing University of Chemical Technology
2023
Science and Technology Facilities Council
2023
Shanghai Institute of Pharmaceutical Industry
2020-2022
Shanghai Drug Administration
2022
Wenzhou Medical University
2022
Hunan University of Technology
2019-2021
Triazole demonstrates distinctive physicochemical properties, characterized by weak basicity, various dipole moments, and significant dual hydrogen bond acceptor donor capabilities. These features are poised to play a pivotal role in drug–target interactions. The inherent polarity of triazole contributes its lower logP, suggesting the potential improvement water solubility. metabolic stability adds additional value drug discovery. Moreover, metal-binding capacity nitrogen atom lone pair...
A general 1,2-selenosulfonylation of alkynes with high levels regio- and stereoselectivity was realized under mild conditions.
The similarities and differences of eight vegetable oils produced in China were investigated terms their fatty acid, sterol, tocopherol compositions subsequent data processing by hierarchical clustering analysis principal component analysis. lipid profiles, acquired analytical techniques tailored to each class, revealed great among the acid profiles corn sesame oil as well few sterol profiles. It turns out that not only was there similarity between but also too many for Sunflower tea-seed...
A facile one-pot tetramerization of indolin-2-one with phosphoryl chloride was applied for the first convenient direct synthesis C2v-symmetric cyclooctatetraindole an 8π annulene as center. Tetra- and octa-arylated derivatives functionalized fluorescent fluorene pyrene units were thus facilely synthesized characterized.
A highly efficient cross-coupling of diarylborinic acids and anhydrides with aryl chlorides bromides has been effected by using a palladium catalyst system co-supported strong σ-donor N-heterocyclic carbene (NHC), N,N'-bis(2,6-diisopropylphenyl) imidazol-2-ylidene, π-acceptor phosphite, triphenylphosphite, in tert-BuOH the present K(3)PO(4)·3H(2)O. Unsymmetrical biaryls variety functional groups could be obtained good to excellent yields as low 0.01, 0.2-0.5, 1 mol % loadings for activated...
A rapid access to α-carbonyl selenocyanates has been developed through the direct selenocyanation of aromatic ketones.
This work studied the interactions of an oppositely charged surfactant mixture oleyl bis(2-hydroxyethyl)methyl ammonium bromide (OHAB) and sodium dodecyl sulfate (SDS) with 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (DOPC) vesicles as well penetration OHAB/SDS through model skin, aimed at understanding relationship between ability different aggregates in solubilizing phospholipid their potential irritating skin. By changing molar fraction OHAB (XOHAB), five kinds are constructed:...
Interactions of multivalent metal counterions with anionic sulfonate gemini surfactant 1,3-bis(N-dodecyl-N-propanesulfonate sodium)-propane (C12C3C12(SO3)2) and the induced aggregate transitions in aqueous solution have been studied. Divalent ions Ca2+, Mg2+, Cu2+, Zn2+, Mn2+, Co2+, Ni2+ trivalent Al3+, Fe3+, Cr3+ were chosen. The results indicate that critical micelle concentration (CMC) C12C3C12(SO3)2 is greatly reduced by ions, morphologies are adjusted changing nature molar ratio ions....
Self-nanoemulsifying drug delivery system (SNEDDS) have been considered as a promising platform for oral of many BCS (biopharmaceutics classification system) class IV drugs, such docetaxel (DTX). However, chemotherapy with DTX is also restricted by its active P-glycoprotein (P-gp) efflux and hepatic first-pass metabolism. To address these challenges, we developed novel SNEDDS co-loaded cyclosporine A (CsA) to achieve effective inhibition P-gp P450 enzyme metabolization, improving...
Abstract Anthocyanins have attracted attention over the past several decades because of their beneficial health effects. In this research, a strategy combining column chromatography and high‐speed countercurrent was developed for separation high‐purity anthocyanin monomers from mulberry fruits. After purification using Amberlite XAD‐7HP with 80% ethanol (0.1% HCl), fraction anthocyanins mixtures purity 68.6% obtained. High‐speed biphasic solvent system n ‐butanol/methyl tert ‐butyl...
A new, simple, and metal-free route for the diselenation of maleimides has been first developed employing (bis(trifluoroacetoxy)iodo)benzene (PIFA) at room temperature. The present method is compatible with different functional groups, various diselenyl were obtained in moderate to excellent yields. Moreover, this protocol further highlights unique practical application functionalization biologically relevant molecules amino acid derivatives. Preliminary mechanism studies suggest that...
The aggregation behavior of cationic ammonium gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12) with chelating molecule ethylenediaminetetraacetic acid (EDTA) and the effects calcium bromide (CaBr2) on structure morphology aggregates in mixture have been investigated by surface tension, isothermal titration microcalorimetry, electrical conductivity, ζ potential, dynamic light scattering, cryogenic transmission electron microscopy, freeze–fracture 1H NMR...
Accurate quantitative analysis of hormones in cosmetics was achieved through the combination an advanced model with LC-MS/MS, even when significant variations occur sensitivity and signal stability LC-MS/MS.
Abstract Synthetic model triacylglyceride oils are important compounds for applications in pharmaceutical and food chemistry. Herein, a practical highly efficient methodology the synthesis of saturated unsaturated triacylglycerides utilizing fatty acids activated by 1,1’‐carbonyldiimidazole (CDI) has been developed applied deuterated medium chain triglyceride (MCT) oil studies plant‐based diary emulsions. The deuterium labelled were used to gain new insight into mechanism reaction, which was...