A5019131478- Polymer Surface Interaction Studies
- Polymer Nanocomposites and Properties
- Polymer crystallization and properties
- Osteoarthritis Treatment and Mechanisms
- Hydrocarbon exploration and reservoir analysis
- biodegradable polymer synthesis and properties
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Antimicrobial agents and applications
- Geological and Geophysical Studies
- Surfactants and Colloidal Systems
- Asymmetric Synthesis and Catalysis
- Geological Studies and Exploration
- Nanoparticle-Based Drug Delivery
- Adsorption and biosorption for pollutant removal
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Synthetic Organic Chemistry Methods
- Dendrimers and Hyperbranched Polymers
- Bone Tissue Engineering Materials
- Chromium effects and bioremediation
- Knee injuries and reconstruction techniques
- Essential Oils and Antimicrobial Activity
- Orthopaedic implants and arthroplasty
- Geochemistry and Elemental Analysis
Shandong University
2022-2025
Tsinghua University
2020-2024
Beijing Institute of Technology
2024
Chinese Academy of Sciences
2015-2024
Ningbo Institute of Industrial Technology
2024
Xiamen University
2007-2022
University of Chinese Academy of Sciences
2017-2021
Nanjing Medical University
2021
Beijing National Laboratory for Molecular Sciences
2015-2021
Nanjing Brain Hospital
2021
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property joint, where a progressive and irreversible damage articular cartilage consecutive inflammatory response dominate mechanism. In this study, bioinspired by super-lubrication catecholamine chemistry mussel, we successfully developed injectable hydrogel microspheres enhanced controllable drug release for OA treatment. Particularly, lubricating ([email protected]) were fabricated dip coating...
Abstract Surface modification is an important approach to improve osseointegration of the endosseous implants, however it still desirable develop a facile yet efficient coating strategy. Herein, metal–phenolic network (MPN) proposed as multifunctional nanocoating on titanium (Ti) implants for enhanced through early immunomodulation. With tannic acid (TA) and Sr 2+ self‐assembled Ti substrates, MPN coatings provided bioactive interface, which can facilitate initial adhesion recruitment bone...
Different strategies developed for controlled and targeted drug delivery over the past few decades have received immense 1-3 consideration in research clinical applications.Nevertheless, development of responsive system active compounds is still a major challenge; therefore, various systems been studied by applying external stimuli such as electric magnetic fields, ultrasonic waves, light, pressure, pH release behaviors premeditated fashion.To this end, electro-stimulated devices (EDRDs) are...
Osteoarthritis (OA) is a chronic joint disease and its progression pathogenesis are highly associated with the significant increase of friction overproduction reactive oxygen species (ROS) in inflammation. Combination ROS elimination lubrication enhancement may provide novel strategy for treatment OA. In present study, pure biomaterial nondrug system P(DMA-co-MPC), synthesized via free radical copolymerization, was designed developed first time using 2-methacryloxyethyl phosphorylcholine...
Visible light-responsive biodegradable mesoporous silica nanoparticles (bMSNs-AZO/CD-PMPC) were developed for osteoarthritis treatment, which simultaneously achieved lubrication enhancement and anti-inflammation.
Abstract Osteoarthritis is a chronic inflammatory disease characterized by cartilage degeneration. Anti‐inflammatory therapy has limited effects, and effective reduction of wear through lubrication essential. In vivo stability lubricity commercial lubricants are insufficient, leading to failure lubricating treatment progression osteoarthritis. To address these issues, new therapeutic methods combining anti‐inflammation stable high‐performance developed. Inspired the sliding mechanism...
Abstract Treating bacterial biofilm infections on implanted materials remains challenging in clinical practice, as bacteria can be resistant by weakening the host defense from immune cells like macrophages. Herein, a metal‐piezoelectric hetero‐nanostructure with mechanical energy‐driven antimicrobial property is situ constructed Ti implant. Under ultrasonic irradiation, formed piezotronic (piezoTi) promote generation of reactive oxygen species (ROS) facilitating local charge transfer at...
Implant-associated infections (IAI) are great challenges to medical healthcare and human wellness, yet current clinical treatments limited the use of antibiotics physical removal infected tissue or implant. Inspired by protein/membrane complex structure its generation reactive oxygen species in mitochondria respiration process immune cells during bacteria invasion, we herein propose a metal/piezoelectric nanostructure embedded on polymer implant surface achieve efficient piezocatalysis for...
Abstract Osteoarthritis (OA) is a typical joint degenerative disease that prevalent worldwide and significantly affects the normal activities of patients. Traditional treatments using diclofenac (DCF) as an anti‐inflammatory drug by oral administration transdermal delivery have many inherent deficiencies. In this study, lubricating microneedles (MNs) system for treatment osteoarthritis with multistage sustained great reduction in skin damage during MNs penetration developed. The bilayer...
Limited surface lubrication and bacterial biofilm formation pose great challenges to biomedical implants. Although hydrophilic lubricated coatings resistance have been reported, the harsh tedious synthesis greatly compromises their application, more importantly, property has seldom investigated in combination with property. In this study, bioinspired by performances of mussel articular cartilage, we successfully synthesized self-adhesive coating simultaneously achieved optimal properties....
In this study QDs were encapsulated in carboxylated PluronicF127 (F127COOH) triblock polymeric micelles and conjugated with anti-mesothelin antibody for the purpose of alleviating potential toxicity, enhancing stability improving targeting efficiency CdTe/ZnS quantum dots (QDs) tumors. The amphiphilic polymer F127COOH contains hydrophilic poly(ethylene oxide) (PEO) hydrophobic poly(propylene (PPO) units. After encapsulating into F127 (F127COOH-QD) micelles, particles antibodies to allow...
Fluorescent dyes are widely used in chemical, biological, and environmental science. However, the π-π stacking among large π-conjugated groups of dye molecules normally leads to hydrophobicity aggregation, resulting quenching fluorescence intensity. In present work, a kind BODIPY-based fluorescent surfactant C8BCOONa has been synthesized, its self-assembly performances cell membrane imaging photodynamic therapy have studied. This exhibits low critical micellar concentration (CMC) aqueous...
The interfacial interactions of polymer–nanoparticles have dramatical effects on the crystallization behavior grafted polymers. In this study, methoxypolyethylene glycol (MPEG) (molecular weights 750, 2000, and 4000 g mol–1) was onto amino-modified nanosized silica (SiO2-NH2) by "grafting to" method. grafting density molecular weight confined MPEG (MPEG-g-SiO2) were systematically investigated differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), wide-angle X-ray...
Endowing the implanted biomaterial with a wide range of functions, such as lubrication and antibacterial anticoagulation properties, is essential for their safe clinical use. In present study, based on superlubrication mechanism articular cartilage, branched polyelectrolyte polymer (PEI-PMPC) was successfully synthesized tert-butyl hydroperoxide-initiated grafting polymerization then applied to biocompatible polyurethane (PU) surface. Specifically, PU sheet pretreated by polydopamine (PDA),...
Abstract Solar thermal collectors based on phase change materials (PCMs) are important to promote the civilian use of sustainable energy. However, simultaneously achieving high photothermal efficiency and rapid heat transfer PCM carrier typically involves a proportion functional materials, contradicting satisfying energy storage density. In this work, surface‐engineered anisotropic MXene‐based aerogel (LMXA) integrated with myristic acid (MA) produce composites (LMXA‐MA) is reported, in...
ABSTRACT Dental caries represents one of the most widespread oral bacterial infections, affecting billions individuals worldwide and presenting significant public health challenges. Effective diagnosis treatment are hindered by limitations traditional clinical methodologies, which often involve laborious examinations invasive procedures. In this study, we employ an aggregation‐induced emission probe, MeOTpy, for instant molecular detection photodynamic dental caries. MeOTpy interacts...
Bacterial infections pose a significant threat to human health. Catalytic antibacterial nanoparticles that generate reactive oxygen species (ROS) are emerging, as promising therapeutic approach in treating bacterial infection by boosting the innate immune defenses. However, interaction between cells and these catalytic remains poorly understood. Here, using rodent models of infection, we test antimicrobial properties ultrasound-responsive piezo-catalytic (piezoNP). We show piezoNPs strongly...