The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property joint, where a progressive and irreversible damage articular cartilage consecutive inflammatory response dominate mechanism. In this study, bioinspired by super-lubrication catecholamine chemistry mussel, we successfully developed injectable hydrogel microspheres enhanced controllable drug release for OA treatment. Particularly, lubricating ([email protected]) were fabricated dip coating...

Abstract Paracrine is an important mechanism in mesenchymal stem cells (MSCs) that promotes tissue regeneration. However, anoikis attributed to unsuitable adhesion microenvironment hindered this paracrine effect. In study, a living and injectable porous hydrogel microsphere with long‐term activity constructed via the freeze‐drying microfluidic technology incorporation of platelet‐derived growth factor‐BB (PDGF‐BB) exogenous MSCs. Benefiting from structure superior mechanical property...

There are still challenges in applying drug nanocarriers for situ sustained macrophage targeting and regulation, due to the rapid clearance of burst release vivo. Herein, a nanomicelle-hydrogel microsphere, characterized by its macrophage-targeted nanosized secondary structure that allows it accurately bind M1 macrophages through active endocytosis, is employed addresses insufficient osteoarthritis therapeutic efficacy caused nanocarriers. The 3-dimensional microsphere can prevent escape...

Abstract Osteoarthritis, a lubrication dysfunction related disorder in joint, is characterized by articular cartilage degradation and joint capsule inflammation. Enhancing lubrication, combined with anti‐inflammatory therapy, considered as an effective strategy for osteoarthritis treatment. Herein, based on the ball‐bearing‐inspired superlubricity mussel‐inspired adhesion, superlubricated microsphere, i.e., poly (dopamine methacrylamide‐to‐sulfobetaine methacrylate)‐grafted microfluidic...

The balance of redox homeostasis is key to stem cell maintenance and differentiation. However, this disrupted by the overproduced reactive oxygen species (ROS) in pathological conditions, which seriously impair therapeutic efficacy cells. In present study, highly dispersed fullerol nanocrystals with enhanced bioreactivity were incorporated into hydrogel microspheres using one-step innovative microfluidic technology construct fullerol-hydrogel spheres (FMSs) for situ regulating cells...

The localization and accumulation of drugs in the body determine their therapeutic effects; however, specific microstructure damaged tissues hinders drug delivery. Currently, there is a shortage effective carriers to breach these barriers achieve efficient tissue cellular delivery drugs. In this study, an injectable double positively charged functional hydrogel microsphere with "targeting cartilage extracellular matrix", "cartilage penetration", "cellular phagocytosis" designed for matching...

Abstract The worldwide prevalence of musculoskeletal disorders is expected to rise due an accelerating aging population and increasing associated factors. Despite the high rate disability induction, clinical options for treatment remain limited. Hydrogel microspheres (HMSs), which are colloidal particles with crosslinked polymer networks at nanometer scale, characterized by excellent biocompatibility, easy‐to‐tune structures (e.g., stiffness, porosity, composition), encapsulation efficiency...

Under pathological conditions, the joint is not well lubricated, which inevitably leads to osteoarthritis. Currently, in clinics injection of hyaluronic acid (HA) as an intra-articular viscosupplement one main methods for alleviation However, viscosity HA reduces dramatically under high shear rate due shear-thinning effect. Therefore, it crucial enhance lubrication property order treat osteoarthritis effectively. In this study, we successfully grafted 2-methacryloyloxyethyl phosphorylcholine...

Abstract The occurrence of osteoarthritis is closely related to progressive and irreversible destruction the articular cartilage, which increases friction significantly causes further inflammation joint. Thus, a scaffold for cartilage defects should be developed via lubrication restoration drug intervention. In this study, we successfully synthesized gelatin-based composite hydrogels, namely GelMA-PAM-PMPC, with properties biomimetic sustained release by photopolymerization methacrylic...

The role of arthroereises in the treatment adult acquired flatfoot deformity (AAFD) has been controversial. This study aims to evaluate outcome subtalar arthroereisis treating stage II AAFD. A total 24 feet with AAFD were treated surgically between 2009 and 2011 using arthroereisis. average follow-up was 29.7 months (range = 35 months). postoperative AOFAS (American Orthopaedic Foot Ankle Society) Ankle-Hindfoot Scale score 85.6 (compared 51.7 preoperatively). Average preoperative...

Abstract Background The filamentous fungus Trichoderma reesei is one of the best producers cellulase and has been widely studied for production cellulosic ethanol bio-based products. We previously reported that Mn 2+ N , -dimethylformamide (DMF) can stimulate overexpression via Ca bursts calcium signalling in T. under cellulase-inducing conditions. To further understand regulatory networks involved we characterised /DMF-induced pathway stimulation overexpression. Results found /DMF...

Large cystic osteochondral defects of the talus can be challenging to treat. This retrospective control study looked at use autograft transfer combined with cancellous allograft in patients advanced cartilage and subchondral bone damage talus.Thirteen were treated large defect between February 2010 July 2013. All these larger than 15 mm diameter. The filled center lesions sealed an cylinder that was harvested from ipsilateral medial femoral condyle. visual analog scale (VAS) score for pain...

Background: Intramuscular lengthening of the gastrocnemius and/or soleus (Baumann procedure) is widely used in patients who have cerebral palsy, with several advantages over other techniques. Tightness or gastrocnemius-soleus complex has been confirmed to be related flatfoot deformity. The purpose this study was evaluate mid-term results Baumann procedure as a part treatment equinus Methods: We reviewed 35 pediatric and adult (43 feet) underwent for concomitant mean duration follow-up 39.4...

(001) oriented Pt thin films with excellent single crystal quality were epitaxially grown on SrTiO3. The interface relationship was determined and shown to be (001)Pt∥(001)STO [100]Pt∥[100]STO. Two unexpected “transitions” found at 138 34K in the evolution of resistivity temperature as samples heated up, which can probably attributed phase transitions crystalline fact that epitaxial film growth is observed under oxygen plasma believed a result ashing S-containing impurities target.

Background It is still unknown whether the excessive length of first ray a risk factor for hallux valgus recurrence. The purpose this study to clarify relationship between and recurrence valgus. Methods Between 2008 2011, total 186 feet (left 105, right 81) who underwent chevron osteotomy combined with distal soft tissue procedure in our foot ankle center were retrospectively reviewed. A postoperative angle(HVA) ≥20° was defined as Patients divided into two groups: non-recurrence group....

Background: Subtalar arthrodesis is a common therapy for subtalar joint disorders. In this article, we evaluate the effect of on ankle and hindfoot joints. Methods: Fifty patients (33 men 17 women) underwent between January 1, 1996, August 31, 2011. The 36-item Short-Form Health Survey American Orthopaedic Foot Ankle Society scores were used clinical evaluation. Radiographic analysis included assessment degenerative changes function in frontal sagittal planes. Results: Thirty-seven (27 10...

The NiAl intermetallic layers and matrix composite with TiC particulate reinforcement were successfully synthesized by laser cladding coaxial powder feeding of Ni/Al clad Ni/Al+TiC mixture, respectively. With optimized processing parameters mixture compositions, the free cracks metallurgical bond substrate. microstructure laser-synthesized was composed β-NiAl phase a few γ phases for intermetallic; unmelted TiC, dispersive fine precipitated particles refined reinforced composite. average...

Schau wie es schrumpft: Durch systematische Modifizierung lässt sich aus Polymethylmethacrylat ein chemomechanisches Polymer erhalten, das in menschlichem Blutplasma selektiv Gegenwart von physiologischen Mengen Glucose kontrahiert. Dieses Verhalten zeigt eine gute Reversibilität und ermöglicht so kontinuierliche Expansions-Kontraktions-Zyklen.