A5100749625- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Orthopaedic implants and arthroplasty
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Erythrocyte Function and Pathophysiology
- Microtubule and mitosis dynamics
- Cervical Cancer and HPV Research
- Immune cells in cancer
- Muscle metabolism and nutrition
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Sleep and related disorders
- Osteoarthritis Treatment and Mechanisms
- Obesity, Physical Activity, Diet
Peking University People's Hospital
2020-2024
Peking University
2020-2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Wellcome Centre for Cell-Matrix Research
2023
University of Manchester
2023
Shanghai University of Sport
2022
Peking Union Medical College Hospital
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
There are still challenges in applying drug nanocarriers for situ sustained macrophage targeting and regulation, due to the rapid clearance of burst release vivo. Herein, a nanomicelle-hydrogel microsphere, characterized by its macrophage-targeted nanosized secondary structure that allows it accurately bind M1 macrophages through active endocytosis, is employed addresses insufficient osteoarthritis therapeutic efficacy caused nanocarriers. The 3-dimensional microsphere can prevent escape...
Adhesion between cells and the extracellular matrix is mediated by heterodimeric ( αβ ) integrin receptors that are intracellularly linked to contractile actomyosin machinery. One of proteins control this link talin, which organizes cytosolic signalling into discrete complexes on β-integrin tails referred as focal adhesions (FAs). The adapter protein KANK1 binds talin in region FAs known adhesion belt. Here, we adapted a non-covalent crystallographic chaperone resolve talin–KANK1 complex....
Endometrial cancer (EC) is the most common gynecologic cancer. Unfortunately, its prognosis remains poor due to limited screening and treatment options. To address this issue, present study evaluated predictive value of four immunohistochemical (IHC) indicators for overall survival (OS) recurrence-free (RFS) in patients with EC. A total 834 diagnosed EC were included at Peking University People's Hospital between January 2006 December 2020. These randomly divided into training validation...
Purpose To assess the acute effect of pre-sleep protein supplementation combined with resistance exercise on energy metabolism (including 24-h total expenditure (TEE), sleep (SEE), basal (BEE), glycolipid oxidation, and appetite sedentary adults. Methods A thirty-one participants completed this randomized, double-blind, crossover study. Participants following experimental conditions in random order Human Calorimeter chamber: (1) 40-g dinner before a nighttime exercise, followed by placebo...
Abstract Endometrial cancer (EC) is a common malignant tumor of female reproductive system. It seriously affects women's health. The mechanical characteristics EC have not been paid noticed. However, the different types are diverse. These will greatly influence development and prognosis cells. In this study, we explored traction force in primary cells cell lines for first time. was found that or with metastatic capability lower. Various clinicopathological features patients significantly...