A5085107020- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Plant and animal studies
- Plant and Fungal Species Descriptions
- Thermochemical Biomass Conversion Processes
- Plant Reproductive Biology
- Oral microbiology and periodontitis research
- Coal Properties and Utilization
- Tuberculosis Research and Epidemiology
- vaccines and immunoinformatics approaches
- GaN-based semiconductor devices and materials
- Molecular Sensors and Ion Detection
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- Ga2O3 and related materials
- Coal and Its By-products
- Bacterial biofilms and quorum sensing
- Long-Term Effects of COVID-19
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Neurobiology and Insect Physiology Research
- Biosensors and Analytical Detection
- Immune Response and Inflammation
- Periodontal Regeneration and Treatments
Shandong University
2023-2025
Huazhong University of Science and Technology
2020-2024
Hubei Academy of Agricultural Sciences
2024
Chang'an University
2022-2024
Liaoning Normal University
2023
Xi'an Jiaotong University
2020-2022
South China University of Technology
2022
Center for Excellence in Molecular Plant Sciences
2019-2021
Chinese Academy of Sciences
2021
University of Chinese Academy of Sciences
2019-2021
To fully decipher the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein, it is essential to assess which part highly immunogenic in a systematic way. We generate linear epitope landscape protein by analyzing serum immunoglobulin G (IgG) response 1,051 disease 2019 (COVID-19) patients with peptide microarray. reveal two regions rich epitopes, i.e., C-terminal domain (CTD) and region close S2′ cleavage site fusion peptide. Unexpectedly, we find that...
Abstract Background The missing asymptomatic COVID‐19 infections have been overlooked because of the imperfect sensitivity nucleic acid testing (NAT). Globally understanding humoral immunity in carriers will provide scientific knowledge for developing serological tests, improving early identification, and implementing more rational control strategies against pandemic. Measure Utilizing both NAT commercial kits serum IgM IgG antibodies, we extensively screened 11 766 epidemiologically...
CRISPR/Cas9-mediated genome editing is a powerful technology that has been used for the genetic modification of number crop species. In order to evaluate efficacy CRISPR/Cas9 in root crop, sweet potato (Ipomoea batatas), two starch biosynthetic pathway genes, IbGBSSI (encoding granule-bound synthase I), and IbSBEII branching enzyme II), were targeted starch-type cultivar Xushu22 carotenoid-rich Taizhong6. I. batatas was transformed using binary vector, which Cas9 gene driven by Arabidopsis...
Depression is characterized by oxidative stress in the brain. As crucial reductive biothiol, cysteine (Cys) directly regulates occurrence of Despite its significance, precise exploration Cys mouse brains remains a challenge, primarily owing to limitations Cys-monitoring tools, especially interference from unavoidable reaction with other biothiols. Thus, we developed novel two-photon fluorescence probe for based on new specific recognition site, thiobenzoate. Encountering Cys, carbon–sulfur...
A near-infrared fluorescent probe was exploited to sensitively visualize ozone in the brains of mice with depression phenotypes <italic>in situ</italic>.
Abstract Serological tests play an essential role in monitoring and combating the COVID-19 pandemic. Recombinant spike protein (S protein), especially S1 protein, is one of major reagents used for serological tests. However, high cost S production possible cross-reactivity with other human coronaviruses pose unavoidable challenges. By taking advantage a peptide microarray full coverage, we analyzed 2,434 sera from 858 patients, 63 asymptomatic patients 610 controls collected multiple...
Understanding the complexities of immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key gain insights into durability protective immunity against reinfection.We sought evaluate SARS-CoV-2 in convalescent patients with longer follow-up time.SARS-CoV-2-specific humoral and cellular responses were assessed disease 2019 (COVID-19) at 1 year postinfection.A total 78 COVID-19 (26 moderate, 43 severe, 9 critical) recruited after recovery. The positive rates both...
The immunogenicity of the SARS-CoV-2 proteome is largely unknown, especially for non-structural proteins and accessory proteins. In this study, we collect 2,360 COVID-19 sera 601 control sera. We analyze these on a protein microarray with 20 SARS-CoV-2, building an antibody response landscape immunoglobulin (Ig)G IgM. Non-structural NSP1, NSP7, NSP8, RdRp, ORF3b, ORF9b elicit prevalent IgG responses. patterns dynamics non-structural/accessory are different from those S N responses against...
Conventional treatment to periodontal and many other bone defects requires the use of barrier membranes guided tissue regeneration (GTR) (GBR). However, current normally lack ability actively regulate repairing process. Herein, we proposed a biomimetic engineering strategy enabled by new type Janus porous polylactic acid membrane (PLAM), which was fabricated combining unidirectional evaporation-induced pore formation with subsequent self-assembly bioactive metal-phenolic network (MPN)...
The initiation and development of storage roots (SRs) are intricately regulated by a transcriptional regulatory network. One key challenge is to accurately pinpoint the tipping point during transition from pre-swelling SRs identify core regulators governing such critical transition. To solve this problem, we performed dynamic network biomarker (DNB) analysis transcriptomic dynamics root in Ipomoea batatas (sweet potato). First, our identified stage-specific expression patterns for...
Abstract Storage roots of sweet potato are important sink organs for photoassimilates and energy, carbohydrate metabolism in storage affects yield starch production. Our previous study showed that H + -pyrophosphatase (IbVP1) plays a vital role mitigating iron deficiency positively controls fibrous root growth. However, its roles regulating production have not been investigated. In this study, we found IbVP1 overexpression improved the photosynthesis ability sucrose content source leaves...
ABSTRACT Dental caries represents one of the most widespread oral bacterial infections, affecting billions individuals worldwide and presenting significant public health challenges. Effective diagnosis treatment are hindered by limitations traditional clinical methodologies, which often involve laborious examinations invasive procedures. In this study, we employ an aggregation‐induced emission probe, MeOTpy, for instant molecular detection photodynamic dental caries. MeOTpy interacts...
Cerebral ischemia reperfusion injury (CIRI) is closely related to lipid peroxidation. Malondialdehyde (MDA), as a biomarker of peroxidation, prone addition with biomacromolecules, resulting in secondary cerebral injury. However, desirable tools for vivo-determining MDA are scarce. Thus, we devised innovative polymer carbon dots carbonized by benzoyl hydrazine and named them BH-PCDs. BH-PCDs covered groups directly form from one-pot synthesis. The functional nanoparticle specifically...
Depression is immensely attributed to the overactivation of N-methyl-d-aspartic acid (NMDA) receptor in brains. As regulatory binding partners NMDA receptor, both Zn2+ and H+ are intimately interrelated receptor's activity. Therefore, exploring synergistic changes on levels brains will promote knowledge treatment depression. However, lack efficient, appropriate imaging tools limits simultaneously tracking living mouse Thus, a well-designed dual-color fluorescent probe (DNP) was fabricated...
Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) is the most commonly used and powerful method for gene expression analysis due to its high sensitivity, specificity, throughput, accuracy of this approach depends on stability reference genes normalization. Taihangia rupestris Yu & Li (Rosaceae), an andromonoecious plant, produces both bisexual flowers unisexual male within same individual. Using qRT-PCR technique, investigation profiling in staminate perfect...
Caries are one of the most common oral diseases caused by pathogenic bacterial infections, which widespread and persistently harmful to human health. Using nanoparticles invade biofilms produce reactive oxygen species (ROS) in situ is a promising strategy for killing bacteria disrupting structure biofilms. In this work, biofilm-targeting Fenton nanoreactor reported that can generate ROS responsive cariogenic microenvironment. The constructed metal-phenolic encapsulation calcium peroxide (CaO
Chip seal is an efficient maintenance strategy for bituminous pavements, with aggregate shape significantly impacting its embedment and performance, but there limited quantification of effects. Using the Aggregate Image Measurement System II (AIMS-II) classification, this study investigated influence on chip seal's macrotexture performance through a series tests, including 3D laser scanning test, coverage skid resistance sweep employing response surface methodology (RSM) quantification....
Taihangia rupestris, an andromonoecious plant species, bears both male and hermaphroditic flowers within the same individual. However, establishment development of in remain poorly understood, due to limited genetic sequence information. To investigate potential molecular mechanism regulation flower formation, we used de novo RNA sequencing compare transcriptome profiles at early late developmental stages. Four cDNA libraries, including floral bud, flower, were constructed sequenced by using...