A5042150708- COVID-19 Clinical Research Studies
- Microtubule and mitosis dynamics
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Genomics and Chromatin Dynamics
- Advanced Breast Cancer Therapies
- DNA Repair Mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Photosynthetic Processes and Mechanisms
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Congenital heart defects research
- Heavy Metal Exposure and Toxicity
- ATP Synthase and ATPases Research
- Neonatal Health and Biochemistry
- Metal-Catalyzed Oxygenation Mechanisms
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Thermal Regulation in Medicine
- Cancer-related Molecular Pathways
- Alcoholism and Thiamine Deficiency
- Microbial bioremediation and biosurfactants
Huazhong University of Science and Technology
2020-2024
Nanchang University
2024
The University of Texas Southwestern Medical Center
2014-2017
Howard Hughes Medical Institute
2013-2017
Chinese Academy of Sciences
2008
Lanzhou University
2005
Abstract Background The missing asymptomatic COVID‐19 infections have been overlooked because of the imperfect sensitivity nucleic acid testing (NAT). Globally understanding humoral immunity in carriers will provide scientific knowledge for developing serological tests, improving early identification, and implementing more rational control strategies against pandemic. Measure Utilizing both NAT commercial kits serum IgM IgG antibodies, we extensively screened 11 766 epidemiologically...
Cohesin, along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle chromatin. The wings apart-like protein (Wapl) is key negative regulator of cohesin and forms complex precocious dissociation sisters 5 (Pds5) promote release from Here we report the crystal structure functional characterization human Wapl. Wapl contains flexible, variable N-terminal region (Wapl-N) conserved C-terminal domain (Wapl-C) consisting eight HEAT (Huntingtin, Elongation...
Abstract ABCB10, a member of ABC transporter superfamily that locates in the inner membrane mitochondria, plays crucial roles hemoglobin synthesis, antioxidative stress and stabilization iron mitoferrin-1. Recently, it was found ABCB10 is mitochondrial biliverdin exporter. However, molecular mechanism export by remains elusive. Here we report cryo-EM structures apo (ABCB10-apo) biliverdin-bound form (ABCB10-BV) at 3.67 Å 2.85 resolution, respectively. ABCB10-apo adopts wide-open conformation...
The COVID-19 global pandemic is far from ending. There an urgent need to identify applicable biomarkers for early predicting the outcome of COVID-19. Growing evidences have revealed that SARS-CoV-2 specific antibodies evolved with disease progression and severity in COIVD-19 patients.We assumed may serve as clinical hospitalized patients on admission.By taking advantage a newly developed proteome microarray, we surveyed IgG responses against 20 proteins 1034 admission followed till 66 days....
Abstract Importance Asymptomatic COVID-19 infections have a long duration of viral shedding and contribute substantially to disease transmission. However, the missing asymptomatic cases been significantly overlooked because imperfect sensitivity nucleic acid testing. We aimed investigate humoral immunity in asymptomatics, which will help us develop serological tests improve early identification, understand COVID-19, provide more rational control strategies for pandemic. Objective To better...
Abstract N 6 ‐acetyl‐ L ‐ lysine residue is abundant in dietary protein but little known about its potential influences on the diet‐consumers. Herein, it reported that Lysyl‐tRNA synthetase (KARS) mediates co‐translational deposition of diet‐derived ‐lysine (AcK) nascent proteins to contribute acetylome cells. Acetylated a direct source AcK can widely and substantially regulate multiple organs mice. By analyzing mechanisms underlying contributing mammalian cells, found KARS utilize as an...
Background: The COIVD-19 global pandemic is far from ending. There an urgent need to identify applicable biomarkers for predicting the outcome of COVID-19. Growing evidences have revealed that SARS-CoV-2 specific antibodies remain elevated with disease progression and severity in patients. We assumed may serve as outcome.Method: By taking advantage a newly developed proteome microarray, we surveyed IgM/IgG responses against 20 proteins 1,034 hospitalized COVID-19 patients on admission, who...
Abstract The COVID-19 global pandemic is far from ending. There an urgent need to identify applicable biomarkers for early predicting the outcome of COVID-19. Growing evidences have revealed that SARS-CoV-2 specific antibodies evolved with disease progression and severity in COIVD-19 patients. We assumed may serve as outcome. By taking advantage a newly developed proteome microarray, we surveyed IgG responses against 20 proteins 1,034 hospitalized patients on admission followed till 66 days....