About
Contact & Profiles
A5060999330
Research Areas
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
- Neonatal Health and Biochemistry
Huazhong University of Science and Technology
2022-2023
Abstract ABCB10, a member of ABC transporter superfamily that locates in the inner membrane mitochondria, plays crucial roles hemoglobin synthesis, antioxidative stress and stabilization iron mitoferrin-1. Recently, it was found ABCB10 is mitochondrial biliverdin exporter. However, molecular mechanism export by remains elusive. Here we report cryo-EM structures apo (ABCB10-apo) biliverdin-bound form (ABCB10-BV) at 3.67 Å 2.85 resolution, respectively. ABCB10-apo adopts wide-open conformation...
10.1038/s41467-023-37851-9
article
EN
cc-by
Nature Communications
2023-04-11
10.1016/j.antiviral.2022.105519
article
EN
Antiviral Research
2022-12-30
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