A5075989197- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Natural product bioactivities and synthesis
- Astrophysics and Cosmic Phenomena
- Radio Astronomy Observations and Technology
- DNA Repair Mechanisms
- Bacteriophages and microbial interactions
- Sesquiterpenes and Asteraceae Studies
- DNA and Nucleic Acid Chemistry
- Carbon Nanotubes in Composites
- Pulsars and Gravitational Waves Research
- Advanced Biosensing Techniques and Applications
- Plant Toxicity and Pharmacological Properties
- Phytochemistry and Biological Activities
- Virus-based gene therapy research
- Advancements in Transdermal Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Gamma-ray bursts and supernovae
- Disaster Management and Resilience
- CRISPR and Genetic Engineering
- Nanopore and Nanochannel Transport Studies
- Neutrino Physics Research
- Molecular Junctions and Nanostructures
- Advanced Fluorescence Microscopy Techniques
University of Florida
2021-2025
La Trobe University
2018-2025
Gannan Normal University
2025
Zhujiang Hospital
2021-2024
Southern Medical University
2021-2024
Sun Yat-sen University
2024
Stanford University
2020-2024
Beijing Jiaotong University
2024
Inner Mongolia University of Technology
2021-2024
Michigan United
2024
The liver plays a critical role in both immune defense and tolerance the body. liver-resident cells (LrICs) determine properties, but unique composition heterogeneity of these are incompletely understood. Here, we dissect diversity LrICs by comprehensive transcriptomic profiling using unbiased single-cell RNA-sequencing (scRNA-seq). A total 70, 706 CD45+ from paired perfusion, spleen peripheral blood as references were profiled. We identified more than 30 discrete cell populations comprising...
The unique physical properties of single-walled carbon nanotubes (SWCNTs) have been exploited in novel applications various fields including electronics and life sciences. Their photoluminescence the near-infrared (NIR) range, where optical interference from biological tissues is minimum, has rendered them particularly attractive as probes environments. Herein we review use SWCNT NIR emission bio-sensing imaging. To interface insoluble with an aqueous environment, biomaterials organic...
Dynamic DNA enzyme-based walkers complete their stepwise movements along the prescribed track through a series of reactions, including hybridization, enzymatic cleavage, and strand displacement; however, overall translocation kinetics is not well understood. Here, we perform mechanistic studies to elucidate several key parameters that govern processivity walkers. These include enzyme core type structure, upper lower recognition arm lengths, divalent metal cation species concentration. A...
M2-like polarized tumor-associated macrophages (TAMs) are the major component of infiltrating immune cells in hepatocellular carcinoma (HCC), which have been proved to exhibit significant immunosuppressive and pro-tumoral effects. However, underlying mechanism tumor microenvironment (TME) educating TAMs express phenotypes is still not fully understood. Here, we report that HCC-derived exosomes involved intercellular communications a greater capacity mediate TAMs' phenotypic differentiation....
We present a generalizable approach for designing biosensors that can continuously detect small-molecule biomarkers in real time and without sample preparation. This is achieved by converting existing antibodies into target-responsive "antibody-switches" enable continuous optical biosensing. To engineer these switches, are linked to molecular competitor through DNA scaffold, such competitive target binding induces scaffold switching fluorescent signaling of changing concentrations. As...
This study investigates the oxidative damage of biomolecules in livers mice treated with morphine intraperitoneally. The DNA as measured by single cell electrophoresis and high-performance liquid chromatography equipped electrochemical UV detection, protein carbonyl content was 2,4-dinitrophenylhydrazine method, malondialdehyde HPLC method. activities antioxidative enzymes, superoxide dismutase, catalase glutathione peroxidase, activity alanine aminotransferase were assayed spectrophotometer...
The spindle checkpoint arrests cells at the metaphase-to-anaphase transition until all chromosomes have properly attached to mitotic spindle. Checkpoint proteins Mad2p and Mad3p/BubR1p bind inhibit Cdc20p, an activator for anaphase-promoting complex (APC). We find that upon activation by microtubule inhibitors benomyl or nocodazole, wild-type Saccharomyces cerevisiae contains less Cdc20p than mutants do, whereas their CDC20 mRNA levels are similar. difference in correlates with half-lives of...
Lidocaine as an analgesic is of particular interest in both acute and chronic pain conditions used via injections or transdermal patches. While are associated with problems such patient incompliance, topical administration lidocaine using patches less efficient due to variability drug absorption among individuals, slower permeation through the skin, hence a resultant undesirable delay effects. To address this clinical problem, we developed microneedle integrated patch (MITP),...
DNA origami has received enormous attention for its ability to program complex nanostructures with a few nanometer precision. Dynamic structures that change conformation in response environmental cues or external signals hold great promises sensing and actuation at the nanoscale. The reconfiguration mechanism of existing dynamic is mostly limited single-stranded hinges relies almost exclusively on hybridization strand displacement. Here, we show an alternative approach by demonstrating...