A5100327073- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
- Orthodontics and Dentofacial Orthopedics
- Chinese history and philosophy
- Bone Metabolism and Diseases
- Advanced Sensor and Energy Harvesting Materials
- Acute Ischemic Stroke Management
- Nanoparticle-Based Drug Delivery
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Epigenetics and DNA Methylation
- Dental Implant Techniques and Outcomes
- RNA Research and Splicing
Sichuan University
2015-2025
Wenzhou Medical University
2018-2025
State Key Laboratory of Biotherapy
2012-2025
Second Xiangya Hospital of Central South University
2023-2025
Central South University
2023-2025
Hunan Institute of Mental Health
2025
Tianjin Children's Hospital
2022-2025
Lishui City People's Hospital
2025
University of Pennsylvania
2011-2024
West China Hospital of Sichuan University
2012-2024
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed formation is mostly unknown. Here, we show increased osteoclastic miR-214-3p associates with both elevated serum exosomal reduced elderly women fractures ovariectomized (OVX) mice. Osteoclast-specific knock-in mice rescued by osteoclast-targeted antagomir-214-3p treatment....
Regenerating periodontal bone tissues in the aggravated inflammatory microenvironment under diabetic conditions is a great challenge. Here, polydopamine-mediated graphene oxide (PGO) and hydroxyapatite nanoparticle (PHA)-incorporated conductive alginate/gelatin (AG) scaffold developed to accelerate regeneration by modulating microenvironment. PHA confers with osteoinductivity PGO provides pathway for scaffold. The promotes transferring endogenous electrical signals cells activating Ca2+...
Abstract Background Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical unloading is associated with serious health consequences. Long non‐coding RNAs (lncRNAs) are implicated as important regulators in numerous physiological and pathological processes. Methods Microarray analysis was performed to identify the differentially expressed lncRNAs skeletal between adult aged mice. The most decreased lncRNA identified. C2C12 mouse myoblast cells were used assess biological...
Abstract Ideal epidermal bioelectronics can be used not only for long‐term detection of physiological signals disease diagnosis but also chronic treatment. Silk, an animal‐derived fiber with good biocompatibility and skin‐affinity, is widely in flexible bioelectronics. However, silk fibers are insulating. In this study, ultralong conductive microfibers (mSFs) fabricated by extracting mSF from raw using a bioinspired extraction‐protection process the assistance polydopamine, followed...
Abstract Objectives Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether interferes chondrocyte ferroptotic cell death during osteoarthritic cartilage degeneration. Materials methods In vivo anterior cruciate ligament transection (ACLT)‐induced OA mouse model an vitro study of chondrocytes microenvironment induced by interleukin‐1β (IL‐1β) exposure were employed. Combined...
The development of thoracic aortic dissection (TAD) is closely related to extracellular matrix degradation and vascular smooth muscle cell (VSMC) transformation from contractile synthetic type. LGMN (legumain) degrades components directly or by activating downstream signals. role in VSMC differentiation the occurrence TAD remains elusive. Microarray datasets concerning aneurysm were downloaded Gene Expression Omnibus database screen differentially expressed genes. Four-week-old male Lgmn...
An essential challenge in diabetic periodontal regeneration is achieving the transition from a hyperglycemic inflammatory microenvironment to regenerative one. Here, we describe polydopamine (PDA)-mediated ultralong silk microfiber (PDA-mSF) and metformin (Met)-loaded zeolitic imidazolate framework (ZIF) incorporated into fibroin/gelatin (SG) patch promote soft hard tissue by regulating immunomodulatory microenvironment. The PDA-mSF endows with reactive oxygen species (ROS)-scavenging...
Abstract Nanotechnology enlightens promising antibacterial strategies while the complex in vivo infection environment poses a great challenge to rational design of nanoplatforms for safe and effective anti-infective therapy. Herein, biomimetic nanoplatform (EV-Pd-Pt) integrating electrodynamic Pd-Pt nanosheets natural ginger-derived extracellular vesicles (EVs) is proposed. The introduction EVs greatly endows EV-Pd-Pt with prolonged blood circulation without immune clearance, as well...
Muscle regeneration is a complex process relying on precise teamwork between multiple cell types, including muscle stem cells (MuSCs) and fibroadipogenic progenitors (FAPs). FAPs are also the main source of intramuscular adipose tissue (IMAT). Muscles without exhibit decreased IMAT infiltration but deficient regeneration, indicating importance in repair process. Here, we demonstrate presence bidirectional crosstalk MuSCs via their secretion extracellular vesicles (EVs) containing distinct...
Inflammatory mediators, many of which activate the signaling nuclear factor kappa B (NFκB), have received increasing attention in field neurogenesis. NFκB regulates neurite outgrowth and neural plasticity as well proliferation/apoptosis terminal differentiation stem cells (NSCs). Early neurogenesis from NSCs produces identical progeny through symmetric division committed daughter asymmetric division. Here, we show that is required for NSC initial differentiation. The canonical IKKβ/IκBα/p65...
The environment of bone marrow mesenchymal stem cells (MSCs) is hypoxic, which plays an important role in maintaining their self-renewal potential and undifferentiated state. MSCs have been proven to possess immunomodulatory properties used clinically treat autoimmune diseases. Here, we tested the effects hypoxia on examined its possible underlying mechanisms. We found that hypoxic stimulation promoted human gingiva–derived (hGMSCs) by enhancing suppressive hGMSCs peripheral blood...
Fishes of the genus Danio exhibit diverse pigment patterns that serve as useful models for understanding genes and cell behaviors underlying evolution adult form. Among these species, zebrafish D. rerio several dark stripes melanophores with sparse iridophores alternate light interstripes dense xanthophores. By contrast, closely related species nigrofasciatus has an attenuated pattern fewer melanophores, interstripes. Here we demonstrate differences in iridophore development presage fully...
Conventional treatment to periodontal and many other bone defects requires the use of barrier membranes guided tissue regeneration (GTR) (GBR). However, current normally lack ability actively regulate repairing process. Herein, we proposed a biomimetic engineering strategy enabled by new type Janus porous polylactic acid membrane (PLAM), which was fabricated combining unidirectional evaporation-induced pore formation with subsequent self-assembly bioactive metal-phenolic network (MPN)...
Background: Recent studies have shown that the presence of systemic inflammation correlates with poor survival in various types cancers. This study investigated usefulness a novel inflammation-based prognostic system, using combination neutrophil lymphocyte ratio (NLR) and platelet (PLR), collectively named CNP, for predicting patients esophageal squamous cell carcinoma (ESCC). Materials methods: The CNP was calculated on basis data obtained day admission: both elevated NLR (>3.45) PLR...
Summary Infection of hepatitis B virus ( HBV ) occurs in ~10% infants ‐infected mothers with positive e antigen HB eAg) after immunoprophylaxis. We aimed to evaluate the safety and efficacy telbivudine used during late pregnancy for preventing mother‐to‐child transmission . conducted a multicenter prospective cohort study 5 hospitals from 2012 2014, which enrolled singleton pregnant women eAg. By their choice, were divided into therapy (telbivudine 600 mg/day, gestation 28‐32 weeks 3‐4...
A series of novel, simple, and useful Salen ligands (56 samples) linking with different non-conjugated alkyl bridges have a small π-conjugated system but exhibit strong red, green, blue AIE.