A5029660002- Hepatitis B Virus Studies
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Temporomandibular Joint Disorders
- Endoplasmic Reticulum Stress and Disease
- Obstructive Sleep Apnea Research
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cellular transport and secretion
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Impact of Light on Environment and Health
- Fibroblast Growth Factor Research
- Oropharyngeal Anatomy and Pathologies
- Inflammatory mediators and NSAID effects
- Advanced Glycation End Products research
- Psoriasis: Treatment and Pathogenesis
- Mesenchymal stem cell research
Sichuan University
2013-2025
Wuhan University
2012-2024
Wuhan Institute of Virology
2021-2024
State Key Laboratory of Oral Diseases
2019-2024
State Key Laboratory of Virology
2021-2024
Hubei University
2024
City University of Hong Kong, Shenzhen Research Institute
2020
Stomatology Hospital
2019
Wuhan General Hospital of Guangzhou
2017
Abstract Objectives Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether interferes chondrocyte ferroptotic cell death during osteoarthritic cartilage degeneration. Materials methods In vivo anterior cruciate ligament transection (ACLT)‐induced OA mouse model an vitro study of chondrocytes microenvironment induced by interleukin‐1β (IL‐1β) exposure were employed. Combined...
Hepatitis B virus (HBV) chronically infects 296 million individuals and there is no cure. As an important step of viral life cycle, the mechanisms HBV egress remain poorly elucidated. With proteomic approach to identify capsid protein (HBc) associated host factors siRNA screen, we uncovered tumor susceptibility gene 101 (TSG101). Knockdown TSG101 in HBV-producing cells, HBV-infected cells transgenic mice suppressed release. Co-immunoprecipitation site mutagenesis revealed that VFND motif...
Hepatitis B virus (HBV) chronically infects 296 million people worldwide, posing a major global health threat. Export of HBV RNAs from the nucleus to cytoplasm is indispensable for viral protein translation and genome replication, however mechanisms regulating this critical process remain largely elusive. Here, we identify key host factor embryonic lethal, abnormal vision, Drosophila-like 1 (ELAVL1) that binds controls their nuclear export. Using an unbiased quantitative proteomics screen,...
This cross-sectional study aimed to investigate the association between insomnia and presence of temporomandibular disorders (TMD) its subtypes in orthodontic patients. A total 648 adult patients (158 males 490 females, median age 26) were included completed a questionnaire containing sociodemographic information, severity index (ISI), five major disorder symptoms (5Ts) checklist, self-reported sleep bruxism. Presence TMD was determined according diagnostic criteria, statistical analyses...
Abstract The abnormal mechanical stress has been considered as a major contributor of temporomandibular joint osteoarthritis (TMJOA), but the mechanism by which it leads to degeneration condylar cartilage remains elusive. double-stranded (dsDNA)-sensing cGAS/STING pathway serves response in many sterile inflammatory responses. In present study, we found that exerted on condyle chondrocytes induced dsDNA leakage from mitochondria cytoplasm activate STING. Upon activation, STING exacerbated...
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) is bringing an unprecedented health crisis to the world. To date, our understanding of interaction between SARS-CoV-2 and host innate immunity still limited. Previous studies reported that nonstructural protein 12 (NSP12) was able suppress interferon-β (IFN-β) activation in IFN-β promoter luciferase reporter assays, which provided insights into pathogenesis COVID-19. In this study, we...
Autophagic cargoes ensure selective autophagy for the recognition and removal of various cytosolic aggregated proteins, damaged organelles, or pathogens. Stress granules (SGs), as antiviral immune complexes, serve a positive role in type I interferon (IFN) response can be targeted by (termed granulophagy). However, cargo granulophagy remains elusive, it is still unknown whether plays viral infection. Here, we found that histone deacetylase 6 (HDAC6), component RNA-induced SGs, novel...
Hepatitis B virus (HBV) is a hepatotropic DNA that has very compact genome. Due to this genomic density, several distinct mechanisms are used facilitate the viral life cycle. Recently, accumulating evidence show G-quadruplex (G4) in different viruses play essential regulatory roles key steps of Although G4 structures HBV genome have been reported, their function replication remains elusive. In study, we treated an replication-competent cell line and HBV-infected cells with structure...
Mucosa-associated T-lymphocyte (MAIT) cells that are selectively accumulated in the intestinal mucosa may be involved immune regulation. MAIT determined by their Vα7.2-Jα33 (human)/Vα19-Jα33 (mice) invariant chain. The encoding DNA sequences of Human Jα33 and mouse identical. In order to study role IBD we produced anti-Jα33 antibody detect TNBS induced models.Colitis was male BALB/c mice. Jα33+MAIT from normal mice were transferred into as donors. Colitis severity evaluated clinically...
To provide reliable prediction models based on dentoskeletal and soft tissue variables for customizing maxillary incisor positions to optimize digitalized orthodontic treatment planning.This study included 244 Chinese women (age, 18-40 years old) with esthetic profiles after fixed appliances (133 in group I: 1° ≤ The angle between the nasion [N]-A point [A] plane N-B [B] [ANB] 4°; 111 II: 4° < ANB 7°). Dental, skeletal, measurements were performed lateral cephalograms of participants....
Purpose: Paternally expressed gene 10 (PEG10) is important for apoptosis resistance in cancer cells; however, the effect of PEG10 on tumor cell migration remains poorly understood. In this study, we investigated effects proliferation, apoptosis, adhesion and Burkitt’s lymphoma line, Raji. 
 Methods: Apoptosis was induced by 5-fluorouracil (5-FU) pcDNA3.0/PEG10 transiently transfected HEK293T cells PEG10-suppressed Raji cells. siRNAPEG10 used to inhibit expression. Fluorescence-activated...
Prototype foamy virus (PFV) is a member of the oldest family retroviruses and maintains lifelong latent infection in host. The PFV may be maintained by restriction factors viral replication However, mechanisms involved are poorly understood. Here, we found that TBC1D16, TBC domain-containing protein, significantly down-regulated after infection. Tre2/Bub2/Cdc16 (TBC) proteins function as Rab GTPase-activating (GAPs) participates progression some diseases many signaling pathways. whether has...
Commensal microbiota is closely related to Hepatitis B virus (HBV) infection. Gut bacteria maturation accelerates HBV immune clearance in hydrodynamic injection (HDI) mouse model. However, the effect of gut on replication recombinant adeno-associated (AAV)-HBV model with tolerance remains obscure. We aim investigate its role AAV-HBV C57BL/6 mice were administrated broad-spectrum antibiotic mixtures (ABX) deplete and intravenously injected establish persistent replication. community was...
To assess the differences in hyoid bone position patients with and without temporomandibular joint osteoarthrosis (TMJOA).The present cross-sectional study was conducted 427 participants whose osseous status evaluated using cone-beam computed tomography classified into normal, indeterminate (OA), OA. The craniofacial characteristics were cephalograms. Patients divided normal group (N = 89), OA 182), 156). Descriptive statistics, one-way analysis of variance, age- sex-based stratified...
High mobility group box protein 1 (HMGB1) is a versatile molecule that affects the immune system in various ways; however, its role cancer immunity has not yet been completely elucidated. In current study, bone marrow‑derived dendritic cells from BALB/c mice and undifferentiated murine colon carcinoma CT26.WT were used as cellular model to study primary of HMGB1 immunity. Annexin V acridine orange/ethidium bromide staining was assess apoptosis, Cell Counting kit 8 lactate dehydrogenase...
Temporomandibular joint osteoarthritis (TMJ-OA) causes severe symptoms such as chewing difficulties, acute pain and even maxillofacial deformity. However, there is hardly any effective disease-curing strategy because of uncertainty in aetiology. Animal model an excellent tool to investigate the mechanism, prevention treatment on diseases. Currently, although several TMJ-OA animal models have been established, are almost no comparative studies different models, which poses a great challenge...
Bone stromal cells are critical for bone homeostasis and regeneration. Growing evidence suggests that non-stem niche support regeneration via paracrine mechanisms, which remain to be elucidated. Here, we show physiologically quiescent SM22α-lineage expand after injury regulate diverse processes of intramembranous The majority neither act as stem in vivo nor their expression patterns. Dysfunction induced by loss platelet-derived growth factor receptor β (PDGFRβ) impairs repair. We further...
Prototype foamy virus (PFV), a complex retrovirus belonging to Spumaretrovirinae, maintains lifelong latent infection. The maintenance of infection by viruses relies on the repression type I interferon (IFN) response. However, mechanism involving PFV latency, especially regarding suppression IFN response, is poorly understood. Our previous study showed that promotes autophagic flux. underlying and role PFV-induced autophagy in have not been clarified. Here, we report viral structural protein...